Modern biomedical research requires knowledge sharing and inter needs of many cross disciplines. Therefore, close interaction and collaboration among diverse fields are becoming a crucial practice in biomedical science. The ICABS2022 aims to highlight the advancement in both translational and fundamental biomedical research from the international as well as domestic experts on a mutually beneficial basis.
In immunotherapy, T-cell is often the main subject as it plays a central role in the immune response. The PD-1 on T-cell is a protein known as an inhibitory receptor. Though the structure of glycosylated PD-1 is recognized, it’s functional significance, especially on the regulatory mechanism of T-cell activation was largely unknown. This study had established a better characteristic and mechanistic understanding of the interaction between T-cells and tumor cells.
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This research provided evidence that melatonin improves rheumatoid arthritis (RA) conditions when tested on the CIA mouse model. Depending on the dose administered, melatonin was able to inhibit cytokines, specifically tumor necrosis factor- α (TNF-α) and interleukin (IL)-1β expression, which causes inflammation. This attributes to the melatonin’s ability to downregulate three different signaling pathways, mainly, PI3K/AKT, ERK, and NF-κB.
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The findings of this study were to showcase the correlation between exposure of atmospheric pollutants called particulate matter (PM) during pre- and post-natal periods and the development of asthma. It used a comprehensive nationwide birth cohort database to evaluate the association of asthma with the PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 µm) exposure during pregnancy and infancy in Taichung City.
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