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Yuh-Pyng Sher

AFFILIATION:

Graduate Institute of Biomedical Sciences, China Medical University

POSITION TITLE:

Professor

EDUCATION/TRAINING:

      

CHINA MEDICAL UNIVERSITY HOSPITAL, TAIWAN Academia Sinica, TAIWAN

National TAIWAN University, TAIWAN

National TAIWAN University, TAIWAN

NATIONAL TAIWAN University, TAIWAN

POSTDOC POSTDOC PH.D

M.S

B.S

03/07 - 12/09

08/06 - 02/07

09/01 - 07/06

09/94 - 07/96

09/90 - 07/94

CANCER BIOLOGY CANCER BIOLOGY MOLECULAR MEDICINE MEDICAL TECHNOLOGY MEDICAL TECHNOLOGY
 

HONORS:

2022 Boehringer Ingelheim’s Grass Roots Program (Cancer Therapies) 百靈佳殷格翰生醫新創獨角獸Grass Roots支持計劃

2020 The 17th National Innovation Award in the Academic Research Category 第十七屆國家新創獎

2016 Award of Travel Grant of the 75th Annual Meeting of the Japanese Cancer Association

2011 The first place of poster competition in International Symposium on Translational Cancer Research in conjunction with the 15th Annual Meeting of the Taiwan Cooperative Oncology Group

2007 NHRI Postdoctoral Fellowship Award

RESEARCH INTERESTS:

  •  Lung cancer metastasis
  •  Gene therapy
  •  Cancer Immunotherapy
  •  Target Therapy

PUBLICATIONS:

Selected Peer-reviewed Publications (*Correspondence; ✝Co-first author)

  1. Wong SC#, Yeh CC#, Zhang XY, Hsieh CY, Lo CC, Kuo TT, Lin CC, Chao CH, Liu JP, Chang LC, Wang LH, Sher YP* Inhibition of CDCP1 by 8-isopentenylnaringenin synergizes with EGFR inhibitors in lung cancer treatment. Molecular Oncology 2023 Apr 4. doi: 10.1002/1878-0261.13429.

  2. Liu CH†, Liu SH†, Lai YL, Cho YC, Chen FH, Lin LJ, Peng PH, Li CY, Wang SC, Chen JL, Wu HH, Wu MZ, Sher YP, Cheng WC*, Hsu KW*. Using bioinformatics approaches to identify survival-related oncomiRs as potential targets of miRNA-based treatments for lung adenocarcinoma. Computational and Structural Biotechnology Journal 20:4626-4635. August, 2022. 

  3. Lu TL#, Sher YP#, Chen HC#, Cheng WC#, Hsu LH, Lee CC*. Articulatin B chain induced dendritic cells maturation and driven type I T helper cells and cytotoxic T cells activation. Life Sciences 302:120635, May 12, 2022. 

  4. Lin YS, Kuo TT, Lo CC, Cheng WC, Chang WC, Tseng GC, Bai ST, Huang YK, Hsieh CY, Hsu HS, Jiang YF, Lin CY, Lai LC, Li XG, and Sher YP*. ADAM9 functions as a transcriptional regulator to drive angiogenesis in esophageal squamous cell carcinoma. International Journal of Biological Sciences 17(14): 3898-3910, September 7, 2021.

  5. Liu SH, Hsu KW, Lai YL, Lin YF, Chen FH, Peng PH, Lin LJ, Wu HH, Li CY, Wang SC, Wu MZ, Sher YP*, Cheng WC*. Systematic identification of clinically relevant miRNAs for potential miRNA-based therapy in lung adenocarcinoma. Molecular Therapy - Nucleic Acids 25:1-10. May 2021.

  6. Cheng WC, Chang CY, Lo CC, Hsieh CY, Kuo TT, Tseng GC, Wong SC, Chiang SF, Huang KCY, Lai LC, Lu TP, Chao KSC*, and Sher YP*. Identification of theranostic factors for patients with metastasis in early-stage lung adenocarcinoma. Theranostics 11(8):3661-3675. January 26, 2021.

  7. Lin YS, Hsieh CY, Kuo TT, Lin CC, Lin CY, and Sher YP* Resveratrol-mediated ADAM9 degradation decreases cancer progression and provides synergistic effects in combination with chemotherapy. American Journal of Cancer Research 10(11):3828-3837. November 15, 2020.

  8. Chou CW, Huang YK, Kuo TT, Liu JP, Sher YP*. An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases. International Journal of Molecular Sciences 21:7790. October 21, 2020.

  9. Sher YP, Chai KM, Chen WC, Shen KY, Chen IH, Lee MH, Chiu FF, Liu SJ*. A polypeptide of tumor-associated antigen L6 with intrinsic adjuvant activity enhances antitumor immunity. Vaccines 8:620. October 21, 2020.

  10. Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, Lai LC, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X, Hung MC, Sher YP*. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics 10(24):10925-10939. August 29, 2020.

  11. Chou CW, Yang RY, Chan LC, Li CF, Sun LL, Lee HH, Lee PC, Sher YP, Ying HQ, Hung MC*. The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. American Journal of Cancer Research 10(8):2621-2634. August 15, 2020.

  12. Fan CC, Tsai ST, Lin CY, Chang LC, Yang JC, Chen GY, Sher YP, Wang SC, Hsiao M, Chang WC*. EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis. Redox Biology. 34:101571. May 2020.

  13. Ko PH✝, Lenka G✝, Chen YA, Chuang EY, Tsai MH, Sher YP*, Lai LC*. Semaphorin 5A Suppresses Cell Proliferation and Migration in Lung Adenocarcinoma Cells. International Journal of Oncology 56(1): 165–177. January 2020.

  14. Sher YP, Lin SI, Chai KM, Chen IH, Liu SJ*. Endoplasmic reticulum-targeting sequence enhanced the cellular immunity of a tumor-associated antigen L6-based DNA vaccine. American Journal of Cancer Research 9(9):2028-2036. September 15, 2019.

  15. Lin MH, Shen KY, Liu BS, Chen IH, Sher YP, Tseng GC, Liu SJ, Sung WC*. Immunological evaluation of a novel HLA-A2 restricted phosphopeptide of tumor associated Antigen, TRAP1, on cancer therapy. Vaccine: X 1. 100017. 2019 (https://doi.org/10.1016/j.jvacx.2019.100017)

  16. Sher YP, Lee C, Liu SY, Chen YH, Lee MH, Chiu FF, Leng CH*, Liu SJ*. A therapeutic vaccine targeting HPV E6/E7 with intrinsic Toll-like receptor 2 agonist activity induces antitumor immunity. American Journal of Cancer Research 8(12):2528-2537. December 2018.

  17. Lin CY§, Cho CF§, Bai ST, Liu JP, Kuo TT, Wang LJ, Lin YS, Lin CC, Lai LC, Lu TP, Hsieh CY, Chu CN, Cheng DC, Sher YP*. ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT. Scientific Reports 7:15108. November 2017. 

  18. Fan CC, Cheng WC, Huang YC, Sher YP, Liou NJ, Chien YC, Lin PS, Lin PS, Chen CH, Chang WC*. EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma. Scientific Reports 7:14617. November 2017.

  19. Chiu KL✝, Lin YS✝, Kuo TT, Lo CC, Huang YK, Chang HF, Chung EY, Lin CC, Cheng WC, Liu YN, Lai LC*, Sher YP*. ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis. Oncotarget 8(29): 47365-47378. July 18, 2017. DOI:10.18632/oncotarget.17648.

  20. Hsieh CC, Shyr Yi-Ming, Liao WY, Chen TH, Wang SE, Lu PV, Lin PY, Chen YB, Mao WY, Han HY, Hsiao M, Yang WB, Li WS, Sher YP, Shen CN*. Elevation of β-galactoside α2,6-sialyltranferase 1 in a fructose-responsive manner promotes pancreatic cancer metastasis. Oncotarget 8(5): 7691-7709. January 31, 2017. DOI: 10.18632/oncotarget.13845

  21. Lin SI, Huang MH, Chang YW, Chen IH, Roffler S, Chen BM, Sher YP and Liu SJ*. Chimeric peptide containing both B and T cells epitope of tumor-associated antigen L6 enhances anti-tumor effects in HLA-A2 transgenic mice. Cancer Lett 377(2):126-133, 2016.

  22. Liu EY, Huang WY, Chang YC, Tsai MH, Eric Chuang, Kuok QY, Bai ST, Chao LY, Sher YP*, and Lai LC*. Aryl Hydrocarbon Receptor Activates NDRG1 Transcription under Hypoxia in Breast Cancer Cells. Scientific Reports 6:20808. February 2016

  23. Sher YP✝, Lin SI✝, Chen IH, Liu HY, Lin CY, Chiang IP, Roffler S, Chen HW, Liu SJ*. A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model. Oncotarget 7:671. Jan 2016.

  24. Chiu KL, Kuo TT, Kuok QY, Lin YS, Hua CH, Lin CY, Su PY, Lai LC*, and Sher YP*. ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis. Scientific Reports 5:16426. November 2015.

  25. Liu CM, Chiu KL, Chen TS, Chang SM., Yang SY, Chen LH, Ni YL, Sher YP, Yu SL, Ma WL*. Potential therapeutic benefit of combining gefitinib and tamoxifen for treating advanced lung adenocarcinoma. Biomed Res Int 2015(642041):1-11, 2015.

  26. Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC*, Sher YP*. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Research 74(18):5229-43. September 2014

  27. Luo EC, Chang YC, Sher YP, Huang WY, Chuang LL, Chiu YC, Tsai MH, Eric Chuang, and Lai LC*. MicroRNA-769-3p Down-regulates NDRG1 and Enhances Apoptosis in MCF-7 Cells During Reoxygenation. Scientific Reports 4:5908. August 2014

  28. Chang CY, Shen CY, Kang CK, Sher YP, Sheu WHH, Chang CC, Lee TH. Taurine protects HK-2 cells from oxidized LDL-induced cytotoxicity via the ROS-mediated mitochondrial and p53-related apoptotic pathways. Toxicology and Applied Pharmacology 279:351-363. July 2014

  29. Sher YP, Wang LJ, Tsai MH, Kuo TT, Huang CC, Chuang EY, Lai LC*. ADAM9 Up-regulates N-Cadherin via miR-218 Suppression in Lung Adenocarcinoma Cells. PLoS ONE 9(4):e94065. April 2014

  30. Huang ST, Lin CL, Chang YJ, Sher YP, Wu, MJ, Shu KH, Sung FC, Kao CH*. Pneumococcal Pneumonia Infection Is Associated With End-Stage Renal Disease in Adult Hospitalized Patients: A Nationwide Population-Based Cohort Study. Kidney International doi:10.1038/ki.2014.79. 2014

  31. Su PY, Liu SJ, Chen YH, Wu SS, Chen YL, Ke JR, Peng CY, and Sher YP*. Increased IL-8 and IL-1β in the bile of acute cholecystitis patients. BioMedicine 3(4):181-185. December 2013

  32. Liu YJ, Lin YF, Chen YF, Luo EC,

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