Yen-Liang Liu


Master Program of Biomedical Engineering, School of Biomedical Engineering China Medical University, Taiwan


Assistant Professor


University of Texas at Austin Biomedical Engineering Ph.D. 2013 - 2018
National Taiwan University Biomedical Engineering M.S. 2008 - 2010
National Taiwan University Life Science B.S. 2003 - 2008


1. Excellent Professor Award, China Medical University, 2002
2. Young Scholar Fellowship by Ministry of Science and Technology in Taiwan ($1.7 million USD), 2019
3. Young Scholar of North America Taiwanese Professors’ Association, 2018
4. 3rd place of power pitch competition, Texas Taiwanese Biotechnology Association, 2017
5. NATEA Travel Award to 2017 Global Technology and Industry Summit Forum in Taiwan, 2017
6. National Science Foundation Travel Award for Taiwan Thematic Meeting, 2017
7. Studying Abroad Scholarship from Ministry of Education, Taiwan ($32,000 USD), 2016
8. North America Taiwanese Engineering & Science Association (Dallas-Chapter) Scholarship, 2016
9. 1st place of student poster contest, Science, Engineering & Technology Seminar (SETS), 2016
10. Biophysical Society Education Committee Travel Award, 2016
11. Carol Lewis Heideman Endowed Presidential Fellowship in Biomedical Engineering, 2016
12. Graduate Student Professional Development Awards, the University of Texas at Austin, 2015
13. Student of 9th q-bio Summer School and Conference, 2015
14. Minister Award for Educational Civilian Serviceman, 2012
15. 2nd place of poster award, 6th Taiwan Society for Stem Cell Research Annual Meeting, 2010
16. Best poster award, 18th Symposium on Recent Advances in Cellular and Molecular Biology, 2010
17. Honorable Mention, Crazy Idea – Creativity Competition of Biotechnology Investigation
Sponsored by Industrial Development Bureau, Ministry of Economic Affairs, 2009
18. Travel Grant, Foundation for the Advancement of Outstanding Scholarship, 2009
19. Best Poster Award, 4th Kyoto University-National Taiwan University Academic Symposium, 2009


Dr. Liu defines himself as one of the academic entrepreneurs who apply their scholarly knowledge in commercial or non-commercial ventures to improve human health. His research focuses on the instrumentation of advanced fluorescence microscopy and its application in cancer diagnostics. He started his own laboratory at China Medical University in 2019 and is developing a cancer organoid-based high content screening platform for small molecule drugs and immune therapies.


1. Chiang CY, Shen YH, Huang YT, Huang SY, Tsao YC, Sukhbat U, Chiu PC, Son SH, Wang SC, Chiang CS, Liu YL*. “Calcium carbonate-encapsulated STING agonist for anti-cancer immunotherapy.” In preparation.
2. Shen YH, Chiang CY, Huang YT, Tsao YC, Huang SY, Sukhbat U, Chiu PC, Son SH, Wang SC, Liu YL*.“Immunofoam: liquid foam as carrier of immune cells and anti-cancer agents for intraperitoneal
immunotherapy.” In preparation.
3. Sukhbat U, Li HC, Shen YH, Tu CY, Liao WC, Liu YL*. “Deep learning-assisted cytopathological analysis for assessing tumor content of endobronchial ultrasound bronchoscopy-acquired lung biopsy.” In preparation.
4  Chen YI, Chang YJ, Liao SC, Nguyen TD, Yang J, Kuo YA, Hong S, Liu YL, Rylander HG, Santacruz SR, Yankeelov TE, Yeh HC. “Generative adversarial network enables rapid and robust fluorescence lifetimeimage analysis in live cells.” Communications Biology. 2022, IF: 6.548
5. Kim M, Hong S, Yankeelov TE, Yeh HC*, Liu YL* “Deep learning-based classification of breast cancer cells using transmembrane receptor.” Bioinformatics, 2021, IF: 6.931
6. Liu YL, Yen CC, Liu TS, Chang CH, Shih TF, Wang JH, Yang MC, Lin FH, Liu HC “Safety and efficacy of Kartigen® in treating cartilage defects: a randomized, controlled, phase I trial,” Polymers, 2021, IF: 4.967
7. Liu HC, Liu TS, Liu YL, Wang JH, Chang CH, Shih TF, Lin FH “Atelocollagen-embedded chondrocyte precursors as a treatment for grade-4 cartilage defects of the femoral condyle: a case series with up to 9-year follow-up” Biomolecules, 2021, IF: 6.064
8. Liu YL and Liu HC. “Regeneration of knee cartilage defects: human clinical trials." Journal of
Musculoskeletal Research, 2021
9. Liu YL*, Perillo EP, Ang PYK, Kim M, Blocher K, Vu H, Chen YA, Dunn AK, Yeh HC*. “Three-dimensional two-color dual-particle tracking microscope for monitoring DNA conformational changes and nanoparticle landings on live cells.” ACS Nano, 2020, IF: 18.027
10. Chou CKⱡ, Liu YLⱡ (co-first), Chen YI, Huang PJ, Tsou PH, Chen CT, Lee HH, Wang YN, Hsu JL, Yankeelov TE, Kameoka J, Yeh HC, and Hung MC. “Digital receptor occupancy assay in quantifying on-and off- target binding affinities of therapeutic antibodies.” ACS Sensors, 2020, IF: 9.618
11. Liu YLⱡ, Horning AMⱡ, Lieberman B, Kim M, Lin CK, Hung CN, Chou CW, Wang CM, Lin CL, Kirma NB, Liss MA, Vasisht R, Perillo EP, Blocker K, Horng H, Taverna JA, Ruan J, Yankeelov TE, Dunn AK, Huang HM, Yeh HC, Chen CL. “Spatial EGFR dynamics and metastatic phenotypes modulated by upregulated EPHB2 and SRC pathways predicting poor prognosis.” Cancers, 2019, IF: 6.575
12. Chen YI, Chang YJ, Nguyen TD, Liu C, Phillion S, Kuo YA, Vu HT, Liu A, Liu YL, Hong S, Ren P, Yankeelov TE, Yeh HC. “Measuring DNA hybridization kinetics in live cells using a time-resolved 3D single-molecule tracking method.” Journal of the American Chemical Society, 2019, IF: 16.383
13. Nguyen TD, Liu YL, Bi S, Huang SP, Borrego ED, Chen YI, Kuo YA, Yeh HC. “Single-objective multiphoton light-sheet microscopy for tumor organoid screening.” In Multiphoton Microscopy in the Biomedical Sciences XIX 2019 Feb 22 (Vol. 10882, p. 108822P). International Society for Optics and Photonics (proceedings paper).
14. Liu YL, Chou CK, Kim M, Vasisht R, Kuo YA, Liu C, Perillo EP, Chen YA, Blocher K, Horng H, Chen YI, Nguyen DT, Yankeelov T, Hung MC, Dunn AK, and Yeh HC. “Assessing metastatic potential of breast cancer cells based on EGFR dynamics.” Scientific Reports, 2019, IF: 4.996
15. Hassan AM, Wu X, Jarrett JW, Xu S, Yu J, Miller DR, Perillo EP, Liu YL, Chiu DT, Yeh HC, Dunn AK. “Polymer dots enable deep in vivo multiphoton fluorescence imaging of microvasculature.” Biomedical Optics Express, 2018, IF: 3.562
16. Chen YA, Vu H, Liu YL, Chen YI, Nguyen T, Kuo YA, Hong S, Chen YA, Carnahan S, Petty J, Yeh HC. “Improving NanoCluster Beacon performance by blocking the unlabeled NC probes.” Chemical
Communications, 2018, IF: 6.065
17. Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, and Hung MC. “A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues.” Biosensors & Bioelectronics, 2018, IF: 12.545
18. Li CW, Lim SO, Chung EM, ..., Liu YL, ..., Hung MC. “Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.” Cancer Cell, 2018, IF: 38.585
19. Le V, Lee J, Chaterji S, Spencer A, Liu YL, Kim P, Yeh HC, Kim DH, Baker AB. “Syndecan-1 in
mechanosensing of nanotopological cues in engineered materials.” Biomaterials, 2018, IF: 15.304
20. Perillo EP, Jarrett JW, Liu YL, Hassan A, Fernée DC, Goldak JR, Bonteanu A, Spence DJ, Yeh HC, Dunn AK. “Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser.” Light: Science & Applications, 2017, IF: 20.257
21. Obliosca JM, Cheng SY, Chen YA, Llanos MF, Liu YL, Imphean DM, Bell DR, Petty JT, Ren P, Yeh HC. “LNA thymidine monomer enables differentiation of the four single-nucleotide variants by melting temperature.” Journal of the American Chemical Society, 2017, IF: 16.383
22. Liu C, Obliosca JM, Liu YL, Chen YA, Jiang N, Yeh HC. “3D single-molecule tracking enables direct hybridization kinetics measurement in solution.” Nanoscale, 2017, IF: 8.307
23. Liu YL, Perillo PE, Liu C, Yu P, Chou CK, Hung MC, Dunn AK, Yeh HC. “Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking.” Biophysical Journal, 2016, IF: 3.699
24. Liu C, Liu YL, Perillo PE, Dunn AK, Yeh HC. “Single-molecule tracking and its application in biomolecular binding detection.” IEEE J. Sel. Top. Quantum Electron, 2016, IF: 4.653
25. Wang CC, Yang KC, Lin KH, Liu YL, Yang YT, Kuo TF, Chen IH. “Expandable scaffold improves integration of tissue-engineered cartilage: an in vivo study in a rabbit model.” Tissue Engineering Part A, 2016, IF: 4.080
26. Liu Cⱡ, Liu YLⱡ(co-frist), Perillo PE, Jiang N, Dunn AK, Yeh HC. “Improving z-tracking accuracy in the two-photon single-particle tracking microscope.” Applied Physics Letters, 2015, IF: 3.971
27. Chen YA, Obliosca JM, Liu YL, Liu C, Gwozdz ML, Yeh HC. “NanoCluster Beacons enable detection of a single N 6-methyladenine.” Journal of the American Chemical Society, 2015, IF: 16.383
28. Perillo PE, Liu YL, Huynh K, Liu C, Chou CK, Hung MC, Yeh HC, Dunn AK “Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination.” Nature Communications, 2015, IF: 17.694
29. Juul S, Obliosca JM, Liu C, Liu YL, Chen YA, Imphean D.M., Knudsen B.R., Ho YP, Leong KW, Yeh HC. “NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection.” Nanoscale, 2015, IF: 8.307
30. Perillo PE, Liu YL, Liu C, Yeh HC, Dunn AK. “Single particle tracking through highly scattering media with multiplexed two-photon excitation.” SPIE BiOS, 2015.
31. Obliosca JM, Babin M, Liu C, Liu YL, Chen YA, Batson R, Ganguly M, Petty J, Yeh HC. “A complementary palette of NanoCluster Beacons.” ACS Nano, 2014, IF: 18.027
32. Wang CC, Yang KC, Lin KH, Wu CC, Liu YL, Lin FH, Chen IH. “A biomimetic honeycomb-like scaffold prepared by flow-focusing technology for cartilage regeneration.” Biotechnology and Bioengineering, 2014, IF: 4.395
33. Ling TY, Liu YL, Huang YK, Gu SY, Chen HK, Ho CC, Tsao PN, Tung YC, Chen HW, Cheng CH, Lin KH, Lin FH. “Differentiation of lung stem/progenitor cells into alveolar pneumocytes and induction of angiogenesis within a 3D gelatin–microbubble scaffold.” Biomaterials, 2014, IF: 15.304
34. Wang CC, Yang KC, Lin KH, Liu YL, Liu HC, Lin FH. “Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold.” Biomaterials, 2012. IF: 15.304