Jau-Ye Shiu


Graduate Institute of Biomedical Science, China Medical University, Taiwan


Assistant professor


Ph.D. National Taiwan Chiao-Tung University in Materials Science and Engineering 2009
M.Sc. National Taiwan Chung Cheng University in Physics 2004
B.Sc. Chinese Culture University in Physics 2002


2004 Best post award, Actively Controlled Self-Assembly of Colloidal Crystals by
Electrocapillary Effect, Materials Research Society (MRS) fall meeting, US
2004 Paper reported by scientific magazine, Lab on a Chip, August, volume 4, No. 4
2004 Paper reported by scientific magazine, MRS BULLETIN, April, volume 29, No. 4


• Cell biology/Mechanical biology/ Mechanotransduction
• Micro/nano fabrication integrated with microfludic system
• Application of cellular force sensing for drug screening


1. Morteza Aramesh, Diana Stoycheva, Ioana Sandu, Stephan J. Ihle, Jau-Ye Shiu, Csaba Forró , Annette Oxenius , Viola Vogel and Enrico Klotzsch, Nanoconfinement as a mechanobiological stimulus to boost T-cell activation and expansion, Proceedings of the National Academy of Sciences, 2021 118 (40), e2107535118
2. Garif Yalak, Shiu JY, Ingmar Schön, Maria Mitsi, Viola Vogel. Phosphorylated fibronectin enhances cell attachment and upregulates mechanical cell functions, PLoSOne, 2019, 14(7): e0218893
3. Shiu JY, Aires L, Vogel V. Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction, Nature cell Biology, 2018; 20:262-271
4. Foolen J, Shiu JY, Mitsi M, Borochin M, Zhang Y, Chen C, Vogel V. Full-length plasma fibronectin promotes fibroblast to accumulate at the surface of collagen microtissues during cell-induced tissue morphogenesis, PLoS One, 2016; 11(8): e0160369.
5. Walchli T, Pernet V, Weinmann O, Shiu JY, Guzik-Kornacka A, Decrey G, et al. NogoA is a negative regulator of CNS angiogenesis. P Natl Acad Sci USA 2013, 110(21): E1943-E1952.
6. Kuo CW, Chien FC, Shiu JY, Tsai SM, Chueh DY, Hsiao YS, et al. Investigation of the growth of focal adhesions using protein nanoarrays fabricated by nanocontact printing using size tunable polymeric nanopillars. Nanotechnology 2011, 22(26).
7. Kuo CW, Shiu JY, Chien FC, Tsai SM, Chueh DY, Chen PL. Polymeric nanopillar arrays for cell traction force measurements. Electrophoresis 2010, 31(18): 3152-3158.
8. Shiu JY, Kuo CW, Whang WT, Chen PL. Observation of enhanced cell adhesion and transfection efficiency on superhydrophobic surfaces. Lab on a Chip 2010, 10(5): 556558.
9. Shiu JY, Kuo CW, Whang WT, Chen PL. Addressable Cell Microarrays via Switchable Superhydrophobic Surfaces. J Adhes Sci Technol 2010, 24(5): 1023-1030.
10. Shiu JY, Whang WT, Chen PL. Superhydrophobic Coatings for Microdevices.  
Superhydrophobic Surfaces 2009: 439-447.
11. Shiu JY, Whang WT, Chen PL. Behavior of single DNA molecules in the well-ordered nanopores. Journal of Chromatography A 2008, 1206(1): 72-76.
12. Shih PH, Shiu JY, Lin PC, Lin CC, Veres T, Chen P. On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles. J Appl Phys 2008, 103(7).
13. Kuo CW, Shiu JY, Wei KH, Chen PL. Functionalized silver nanowires for live cell study. Chem Lett 2008, 37(6): 610-611.
14. Shiu JY, Whang WT, Chen PL. Superhydrophobic Coatings for Microdevices. J Adhes Sci Technol 2008, 22(15): 1883-1891.
15. Shiu JY, Chen P. Addressable protein patterning via switchable superhydrophobic
microarrays. Adv Funct Mater 2007, 17(15): 2680-2686.
16. Kuo CW, Shiu JY, Wei KH, Chen P. Monolithic integration of well-ordered
nanoporous structures in the microfluidic channels for bioseparation. Journal of
Chromatography A 2007, 1162(2): 175-179.
17. Shiu JY, Chen PL. Active patterning using an addressable microfluidic network. Adv
Mater 2005, 17(15): 1866-+.
18. Shiu JY, Kuo CW, Chen PL. Fabrication of tunable superhydrophobic surfaces.
Smart Materials III 2005, 5648: 325-332.
19. Shiu JY, Kuo CW, Chen PL, Mou CY. Fabrication of tunable superhydrophobic surfaces by nanosphere lithography. Chem Mater 2004, 16(4): 561-564.
20. Shiu JY, Kuo CW, Chen PL. Actively controlled self-assembly of colloidal crystals in microfluidic networks by electrocapillary forces. J Am Chem Soc 2004, 126(26): 80968097.
21. Kuo CW, Shiu JY, Cho YH, Chen P. Fabrication of large-area periodic nanopillar arrays for nanoimprint lithography using polymer colloid masks. Adv Mater 2003, 15(13): 1065
22. Kuo CW, Shiu JY, Chen PL, Somorjai GA. Fabrication of size-tunable large-area periodic silicon nanopillar arrays with sub-10-nm resolution. J Phys Chem B 2003, 107(37): 9950-9953.
23. Kuo CW, Shiu JY, Chen PL. Size- and shape-controlled fabrication of large-area periodic nanopillar arrays. Chem Mater 2003, 15(15): 2917-2920.