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Che-Ming Jack Hu

AFFILIATION:

Institute of Biomedical Sciences, Academia Sinica, Taiwan

POSITION TITLE:

Associate Research Fellow

EDUCATION/TRAINING:

  • Post-Doc           Nanoengineering, UC San Diego             01/2012 to 05/2015
  • Ph.D.                                Bioengineering, UC San Diego                                  12/2011
  • M.S.                                 Bioengineering, UC San Diego                                   06/2008
  • B.S., with Honors              Bioengineering, UC Berkeley                                05/2005Minor                       Electrical Engineering and Computer Science                                    Minor                         Mechanical Engineering  

HONORS:

2023 Outstanding Research Award, National Science and Technology Council, Taiwan (國家科學及技術委員會傑出研究獎)

2022 Outstanding Technology Award by the Taiwan Nanomedicine Society (台灣奈米生醫學會傑出技術獎)

2022 The 10th Y.Z. Hsu Technology Invention Award—Biomedical Technology (有庠科技發明獎)

2021 Academia Sinica Early-Career Investigator Research Achievement Award (年輕學者研究成果獎)

2020 Chen-Yuan Lee Foundation Young Investigator Award in Biomedical Research (李鎮源教授青年研究學者獎)

2020 17th National Innovation Award (國家新創獎)

2019 “Top 1% Highly Cited Researchers” in cross-field research by Clarivate Analytics (高被引學者)

2019 1st Place at the 2019 NBRP BioMed Start-up Challenge (國際生醫加速器合作計畫優勝)

2019 Young Scholar Award of TienTe Lee Biomedical Foundation (李天德青年醫藥科技獎)

2019 Best Poster Award at the 2019 Gordon Research Conference on Cancer Nanotechnology

2019 Excellent Young Investigator Award—Taiwan Biomaterials and Controlled Releases Society

2019 Futuristic Breakthrough Technology Award—awarded by the Ministry of Science and Technology, ROC

2017 Futuristic Breakthrough Technology Award—awarded by the Ministry of Science and Technology, ROC

2016 The Li Foundation Heritage Prize

2016 4th Annual Excellence in Creativity Award for Young Scholar from The Foundation for the Advancement of Outstanding Scholarship.

2016 Member of the Global Young Academy

2014 Selected participant of the 64th Meeting of Nobel Laureates, Lindau, Germany

2013 Chancellor’s Postdoctoral Scholar Award, UCSD 2013— awarded for outstanding research and exhibition of leadership, mentorship and service to 4 top postdoctoral scholars at UCSD.

2011 Siebel Scholar, Class of 2012 – awarded annually for academic excellence and demonstrated leadership to 85 top students from the world’s leading graduate schools.

2010 Best poster award at the 8th International Nanomedicine and Drug Delivery Symposium, Omaha, NE

2003/2004 Guidant Undergraduate Research Fellowship

 

RESEARCH INTERESTS:

Advances in bionanotechnology and cargo-carrying nanocarriers enable existing therapeutics to be reformulated to attain higher potency and safety. Nanotechnology in medicine has shown tremendous value in drug delivery and vaccine preparations, where pharmacokinetics and immune activation can be finely tuned via rational nanomaterials engineering. The research focus of the laboratory is to develop novel therapeutic nanomaterials with an emphasis toward clinical translation. By examining and tackling the interface between materials and biology, we seek to adopt an engineering approach to improve treatments for major diseases including cardiovascular disease, cancer, and infectious disease.

PUBLICATIONS:

  1. Tsai H-H, Huan P-H, Lin CW, Yao B-Y, Liao W-T, Pai C-H, Liu Y-H, Chen H-W*, Hu C-M*. Lymph node follicle-targeting STING agonist nanoshells enable single-shot M2e vaccination for broad and durable influenza protection, Advanced Science, 2023, 2206521. 

  2. Contreras-Llano L, Liu Y-H, Henson T, Meyer C, Baghdasaryan O, Khan S, Lin C-L, Wang A, Hu C-M*, Tan C*. Engineering cyborg bacteria through intracellular hydrogelation. Advanced Science, 2023, 2204175.

  3. Chien C-Y, Lin J-C, Huang C-Y, Hsu C-Y, Yang K-C, Chattopadhyay S, Nikoloutsos N, Hsieh P, Hu C-M*. In situ hydrogelation of cellular monolayers enables conformal biomembrane functionalization for xeno-free feeder substrate engineering. Advanced Healthcare Materials, 2022, 2201708.  

  4. Chen C-H, Liu Y-H, Eskandar A, Ghimire J, Lin L C-W, Fang Z-S, Wimley WC, Ulmschneider JP, Suntharalingam K*, Hu C-M*, Ulmschneider MB*. Integrated design of a membrane-lytic peptide-based intravenous nanotherapeutic suppresses triple-negative breast cancer. Advanced Science, 2022, 2105506.

  5. Lin J-C, Hsu C-Y, Chen J-Y, Fang Z-S, Chen H-W, Yao B-Y, Shiau GHM, Tsai J-S, Gu M, Jung M, Lee T-Y, Hu C-M* Facile transformation of murine and human primary dendritic cells into robust and modular artificial antigen-presenting systems by intracellular hydrogelation. Advanced Materials, 2021, 2101190. Highlighted as inside cover. 

  6. Yang K-C, Lin J-C, Tsai H-H, Hsu C-Y, Shih V, Hu C-M* Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Delivery and Translational Research, 2021, 11(4):1420-1437. 

  7. Lin P-H, Liang C-Y, Yao B-Y, Chen H-W, Pan C-F, Wu L-L, Lin Y-H, Hsu Y-S, Liu Y-H, Chen P-J, Hu C-M*, Yang H-C* Robust induction of resident memory T cells by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses. Molecular Therapy-Methods and Clinical Development, 2021, 21(11), 299-314. 

  8. Chattopadhyay S, Hu C-M*. Nanomedicinal delivery of STING agonists: recent advances in virus vaccination. Nanomedicine, 2020, 15(29):2883-2894.

  9. Huang P-H, Tsai H-H, Liao P-H, Lin Y-H, Chou Y-C, Hu C-M, Chen H-W* Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain. Human Vaccines and Immunotherapeutics, 2020, Sep 29; 1-2. 

  10. Lin S-Y, Yao B-Y, Hu C-M, Chen H-W*. Induction of robust immune responses by CpG-ODN loaded hollow polymeric nanoparticles for antiviral and vaccine applications in chickens. International Journal of Nanomedicine, 2020, 15, 3033-3318.

  11. Chattopadhyay S, Liu Y-H, Fang Z-S, Lin C-L, Lin J-C, Yao B-Y, Hu C-M*. Synthetic immunogenic cell death mediated by intracellular delivery of STING agonist nanoshells enhances anti-cancer chemo-immunotherapy. Nano Letters, 2020, 20, 4, 2246-2256.

  12. Lin C-W, Huang C-Y, Yao B-Y, Lin J-C, Agrawal A, Algaissi A, Peng B-H, Liu Y-H, Huang P-H, Juang R-H, Chang Y-C, Tseng C-T*, Chen H-W*, Hu C-M*. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against Middle East respiratory syndrome coronavirus. Advanced Functional Materials, 2019, 29(28), 1087616. 

  13. Lin J-C, Chien C-Y, Lin C-L, Yao B-Y, Chen Y-I, Liu Y-H, Fang Z-S, Chen J-Y, Chen W-Y, Lee N-N, Chen H-W, Hu C-M*. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nature Communications, 2019, 10: 1057.

  14. Hu C-M, Chen Y-T, Fang Z-S, Chang W-S, Chen H-W. Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection. International Journal of Nanomedicine, 2018, 13:8579-8593.

  15. Liu Y-H, Kuo S-C, Yao B-Y, Fang Z-S, Lee Y-T, Chang Y-C, Chen T-L, Hu C-M*. Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria. Acta Biomaterialia, 2018, 82:133-142. 

  16. Luk B, Jiang Y, Copp J, Hu C-M, Krishnan N, Gao W, Li S, Fang R, Zhang L. Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions. Molecular Pharmaceutics, 2018, 15(9):3723-3728.

  17. Lin C-W, Chattopadhyay S, Lin J-C, Hu C-M*. Advances and opportunities in nanoparticle and nanomaterial-based vaccines against bacterial infections. Advanced Healthcare Materials, 2018, 7(13):e1701395.

  18. Chen H-W, Fang Z-S, Chen Y-T, Chen Y-I, Yao B-Y, Cheng J-Y, Chien G-Y, Chang Y-C, Hu C-M*. Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection. ACS Applied Materials & Interfaces, 2017, 9(46); 39953-39961.

  19. Hu C-M, Chang WS, Fang ZS, Chen YT, Wang WL, Tsai HH, Chueh LL, Takano T, Hohdatsu T, HW Chen. Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus. Scientific Reports, 2017, 7: 13043.

  20. Chattopadhyay S, Chen JY, Chen HW, Hu C-M*. Nanoparticle vaccines adopting virus-like features for enhanced immune potentiation. Nanotheranostics, 2017, 1(3): 233-260.

  21. Hu C-M, Chien CY, Liu MT, Fang ZS, Chang SY, Juang RH, Chang SC, Chen HW. Multi-antigen avian influenza A (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. BMC Biotechnology, 2017, 17:2. 

  22. Lin SY, Li YT, Chen YT, Chen TC, Hu C-M, Chen HW. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. Scientific Reports, 2016, 6, 37725.

  23. Chen H-W, Huang C-Y, Lin S-Y, Fang Z-S, Hsu C-H, Lin J-C, Chen Y-I, Yao B-Y, Hu C-M*. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials, 2016, 106, 111-118.

  24. Cheng B, Toh EK, Chen KH, Chang YC, Hu C-M, Wu HC, Chau LY, Chen P, Hsieh PC. Biomimicking platelet-monocyte interactions as a novel targeting strategy for heart healing. Advanced Healthcare Materials, 2016, 4, 2686-2697.

  25. Dehaini D, Fang R, Luk B, Pang Z, Hu C-M, Kroll A, Yu CL, Gao W, Zhang L. Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery. Nanoscale, 2016, 8, 14411-14419.

  26. Wang F, Fang R, Luk B, Hu C-M, Thamphiwatana S, Dehaini D, Angsantikul P, Kroll A, Pang Z, Gao W, Lu W, Zhang L. Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection. Advanced Functional Materials, 2016, 26, 1628-1635.

  27. Luk B, Fang R, Hu C-M, Copp J, Thamphiwatana S, Dehaini D, Gao W, Zhang K, Li S, Zhang L. Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors. Theranostics, 2016, 6, 1004-1011.

  28. Hu C-M, Fang RH, Wang K-C, Luk BT, Thamphiwatana SK, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel S, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature, 2015, 526, 118-121. Highlighted: Nature 2015, 526, 47-48; Science Translational Medicine 2016, 7, 307ec169.

  29. Fang R, Luk B, Hu C-M*, Zhang L*. Engineered nanoparticles mimicking cell membranes for toxin neutralization. Advanced Drug Delivery Reviews, 2015, 90, 69-80.

  30. Pang Z; Hu C-M, Fang R, Luk B, Gao W, Wang F, Chuluun E, Angsantikul P, Thamphiwatana S, Lu W, Jiang X, Zhang L. Detoxification of organophosphate poisoning using nanoparticle bioscavengers, ACS Nano, 2015, 9, 6450-6458. 

  31. Wang F, Gao W, Thamphiwatana S, Luk B, Angsantikul P, Zhang Q, Hu C-M, Fang R, Copp J, Pornpattananangkul, Lu W, Zhang L. Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection. Advanced Materials, 2015, 27, 3431-3443.

  32. Gao W, Fang R, Thamphiwatana S, Luk B, Li J, Angsantikul P, Zhang Q, Hu, C-M, Zhang L. Modulating antimicrobial immunity via bacterial membrane-coated nanoparticles. Nano Letters, 2015, 15, 1403-1409.

  33. Copp J, Fang R, Luk B, Hu C-M, Gao W, Zhang K, Zhang L. Clearance of pathologic antibodies using biomimetic nanoparticles. Proceedings of the National Academy of Sciences, 2014, 111, 13481-13484. Highlighted: Proceedings of the National Academy of Sciences 2014, 9, 401.

  34. Hu C-M, Zhang L. Nanotoxoid Vaccines. Nano Today, 2014, 9, 401-404.

  35. Fang RH, Hu C-M, Luk B, Gao W, Copp J, Tai Y, O'Connor D, Zhang L. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Letters, 2014, 14, 2181-2188.

  36. Hu C-M, Fang RH, Luk B, Zhang L. Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies. Nanoscale, 2014, 6, 65-75.