SPEAKERS
Tang-Long Shen
AFFILIATION:
NTU College of Medicine Global Innovation Joint-Degree Program (GIP-TRIAD) Program for Plant Medicine, National Taiwan University, Taipei, Taiwan
POSITION TITLE:
Director and Professor
EDUCATION/TRAINING:
1997-2002 PhD. in Cancer Cell Biology in the Department of Molecular Medicine,
Cornell University, USA
1992-1994 MS in Plant Virology in the Institute of Plant Pathology, National Taiwan
University, Taiwan
1987-1991 BS in Plant Pathology in the Department of Plant Pathology and
Entomology, National Taiwan University, Taiwan
HONORS:
1. The Society of Chinese Bioscientists in America (SCBA) 9 th meeting Travel Awards and Fellowship. Aug. 6-10, 2001
2. The American Society for Cell Biology (ASCB) 2001 annual meeting Predoctoral Travel
Awards. Dec. 8-12, 2001
3. Liu Memorial Award in Cornell University for an excellent progress in graduate program and high potential for a successful academic career. 2002
4. American Heart Association Postdoctoral Fellowship. 2003-2005
5. Blind Prevention Foundation Scholar Travel Award. 2010/7-8
6. The 6 th Breast Cancer Outstanding Research Award, Breast cancer prevention foundation, Taipei, Taiwan. 2016/12
7. The 16 th and 18 th National Innovation Award, Development of a small molecule enhancement for erythropoiesis, in the Academic Research Category. Dec. 6, 2019, 「利用腸腦軸線概念 開發改善睡眠之植萃原料Bugu-S TM 」2021
8. 2022 WW the Most Prestigious Medical Doctor Award （史懷哲風雲醫師獎) International Albert Schweitz er Foundation (史懷哲基金會).
RESEARCH INTERESTS:
- Cell signal transduction (integrin and growth factor signaling)
- Cancer biology (metastasis, organotropism, tumor exosomes)
- Molecular Plant-Microbe Interactions
- Microbial metabolites
PUBLICATIONS:
1. Tang-Long Shen, DongCho Han, and Jun-Lin Guan. (2002) The association of Grb7 with phosphoinositides regulates cell migration. J Biol Chem. 277 (32):29069-77
2. Lee Ann Cooper*, Tang-Long Shen* and Jun-Lin Guan. (2003) Regulation of Focal Adhesion Kinase by its Amino-Terminal Domain through an Autoinhibitory Interaction. Mol. Cell. Biol. 23(22):8030-8041. (* equal contribution)
3. Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, Jennifer Aurandt, Tang-Long Shen, Eric R Fearon, Jun-Lin Guan, Min Han, Yi Rao, Kyonsoo Hong & Kun-Liang Guan (2004) Activation of FAK and Src are receptor-proximal events required for netrin signaling . Nature Neuroscience 7, 1213 - 1221
4. Tang-Long Shen , Ann Y.-J. Park, Ana Alcaraz, Xu Peng, Ihn kyung Jang, Pandelakis Koni, Richard A. Flavell, Hua Gu and Jun-Lin Guan (2005) Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 169(6):941-52
5. Ann Y.J. Park, Tang-Long Shen, Shu Chien and Jun-Lin Guan (2009) Role of focal adhesion kinase S732 phosphorylation in centrosome function during mitosis J. Biol. Chem. 284(14):9418-25
6. Pei-Yu Chu, Ling-Ya Huang, Hsiao-Hsin Chen, Chun-Hua Hsu, Chun-Chi Liang, Jun-Lin Guan, Ting-Hsuan Hung, Tang-Long Shen * (2009) Tyrosine phosphorylation of Grb7 by FAK in the regulation of cell migration, proliferation and tumorigenesis J. Biol. Chem. 284(30):20215-26
7. Chun-Jiun Yang, Chi-Fon Chang*, Lin-Ya Huang, Yu-Yung Chang, Tang-Long Shen, and Chun-Hua Hsu*. (2010) Resonance assignments of human C35 (C17orf37) protein, a novel tumor biomarker. Biomol. NMR Assign. 4(2):191-3
8. Chung-Yao Yang, Lin-Ya Huang, Tang-Long Shen*, J. Andrew Yeh* (2010) Cell adhesion, morphology and biochemistry on nano-topographic oxidized silicon surfaces Cells and Materials 20:415-430 (* co-corresponding author)
9. I-Rue Lai, Pei-Yu Chu, Hsiao-Sheng Lin, Jun-Yang Liou, Yee-Jee Jan, Jen-Chieh Lee, Tang-Long Shen* (2010) Autophosphorylation of Tyr-397 of focal adhesion kinase in gastric carcinoma and its clinical significance. American Journal of Pathology 177(4):1629-37 (This article is highlighted by Nature Reviews Gastroenterology and Hepatology 7, 592)
10. Pei-Yu Chu, Tsia-Kun Li, Shih-Torng Ding, I-Rue Lai, Tang-Long Shen* (2010) EGF-induced Grb7 activation promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. Journal Biological Chemistry 285(38):29279-85
11. Li-Ya Wang, Shih-Shun Lin, Ting-Hsuan Hung, Tsai-Kun Li, Nai-Chun, Lin, Tang-Long Shen* (2012) Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing. Microbe-Plant Molecular Interactions 25(5):648-57. (cover page)
12. Shang-Min Chou, Wan-Jung Lai, Tzu-Wen Hong, Jui-Ya Lai, Sheng-Hong Tsai, Yen-Hsun Chen, Sz -Hsien Yu, Cheng-Hsiang Kao, Richard Chu, Shih-Torng Ding, Tsai-Kun Li and Tang-Long Shen* (2014) Synergistic property of Cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells Phytomedicine 21 (12):1516–1524
13. Chun-Yi Lin, Meng-Ling Wu, Tang-Long Shen, Hsin-Hung Yeh and Ting-Hsuan Hung (2015) Development of molecular detection system and field investigation for two citrus viroids in Taiwan. Virology Journal 12(1):11.
14. Yu-Lin Tai, Lih-Charng Chen, Tang-Long Shen* (2015) Emerging roles of focal adhesion kinase in cancer. BioMed Research International: 2015:690690. Epub 2015 Mar 31
15. Yu-Ling Tai, Pei-Yu Chu, I-Rui Lai, Hui-Yuan Tseng, Jun-Yang Liou, Jun-Lin Guan, Tang-Long Shen* (2015) An EGFR/Src-dependent b4 Integrin/FAK complex contributes to the malignancy of breast cancer. Scientific Reports 5, 16408; doi: 10.1038/srep16408
16. Yen-Wen Wang, Tzu-Wen Hong, Yu-Ling Tai, Ying-Jing Wang, Sheng-Hong Tsai, Pham Thi Kim Lien, Tzu-Ho Chou, Jui-Ya Lai, Richard Chu, Shih-Torng Ding, Kenji Irie, Tsai-Kun Li, Shean-Shong Tzean and Tang-Long Shen* (2015) Evaluation of an epitypified Ophiocordyceps formosana (Cordyceps s.l.) for its pharmacological potential. Evidence-based complementary and alternative medicine Volume 2015, Article ID 189891
17. Bruno Costa-Silva, …., Gonçalo Rodrigues, Tang-Long Shen, Knut Jørgen Labori, Inger Marie Bowitz Lothe, Elin H. Kure, Allyson J. Ocean, Jonathan Hernandez, …., Hector Peinado, Ben Stanger, Jacqueline Bromberg, and David Lyden (2015) Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature Cell Biol. 17(6):816-26.
18. Ayuko Hoshino*, Bruno Costa-Silva*, Tang-Long Shen*, ….., Hector Peinado, Jacqueline Bromberg, David Lyden (2015) Tumor exosome integrins determine organotropic metastasis. Nature 527(7578):329-35 (*co-first authors)
19. Yu-Ling Tai, I-Rue Lai, Yu-Ju Peng, Shih-Torng Ding, Tang-Long Shen * (2016) Activation of focal adhesion kinase through an interaction with β4 integrin contributes to colon cancer progression. FEBS letters 590(12):1826-37
20. Huang CW, Hong TW, Wang YJ, Chen KC, Pei JC, Chuang TY, Lai WS, Tsai SH, Chu R, Chen WC, Sheen LY, Takahashi S, Ding ST, Shen TL* (2016) Ophiocordyceps formosana extract improves hyperglycemia and depression in an STZ-induced mouse model BMC Complementary and Alternative Medicine 16(1):310
21. Yu-Ling Tai, Li-Hsuan Tung, Yu-Chi Lin, Pei-Jung Lu, Pei-Yu Chu, Ming-Yang Wang, Wei-Pang Huang, Ko-Chien Lin, Hsinyu Lee, Tang-Long Shen ＊ (2016) Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression. PLoS One 1(9):e0163617
22. Yu-Ling Tai, Ko-Chien Chen, Jer-Tsong Hsieh, Tang-Long Shen* (2018) Exosomes in cancer development and clinical applications. Cancer Science 109(8):2364-2374. doi: 10.1111/cas.13697.
23. 戴佑玲， 陳克儉， 張亞衡， 郭文宏， 張金堅， 沈湯龍 (2018) 癌轉移非隨機發生: 透過胞外泌體進行癌轉移的預測。臺灣醫界 61 (1), 8-12
24. Tai YL, Chu PY, Lee BH, Chen KC, Yang CY, Kuo WH, Shen TL* (2019) Basics and applications of tumor-derived extracellular vesicles. J Biomed Sci. 26(1):35. doi: 10.1186/s12929-019-0533-x
25. Gao YL, Wang YJ, Chung HH, Chen KC, Shen TL, Hsu CC. Molecular networking as a dereplication strategy for monitoring metabolites of natural product treated cancer cells. (2019) Rapid Communications in Mass Spectrometry 34, e8549. doi: 10.1002/rcm.8549
26. Kuo TH, Chung HH, Chang HY, Lin CW, Wang MY, Shen TL, Hsu CC. (2019) Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation. Anal Chem. 91(18):11905-11915. doi: 10.1021/acs.analchem.9b02667.
27. Chu PY, Tai YL, Shen TL. (2019) Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target. Cells. 8(5). pii: E435. doi: 10.3390/cells8050435.
28. Li-En Lin; Chih-Lin Chen; Ying-Chen Huang; Hsin-Hsiang Chung; Chiao-Wei Lin; Ko-Chien Chen; Yu-Ju Peng; Shih-Torng Ding; Ming-Yang Wang; Tang-Long Shen; Cheng-Chih Hsu (2019) Precision Biomarker Discovery Powered by High Spatial Resolution Ambient Ionization Mass Spectrometry Imaging Using Microscopy Image Fusion. Analytica Chimica Acta 1100:75-87
29. Daria Wieczorek, Dobrawa Kwas ́niewska, Li-Hang Hsu, Tang-Long Shen and Ying-Lien Chen (2020) Antifungal Activity of Morpholine and Piperidine Based Surfactants.Tenside Surf. Det. 57 (2), 104-108
30. Tai YL, Lin CJ, Li TK, Shen TL, Hsieh JT, Chen BPC. (2020) The role of extracellular vesicles in prostate cancer with clinical applications. Endocrine-Related Cancer 27 (5), R133-R144. pii: ERC-20-0021.R1. doi: 10.1530/ERC-20-0021.
31. Carolina Soekmadji, Bo Li, Yiyao Huang, …. Antonio Marcilla, Lorraine O’Driscoll, Faezeh Shekari, Tang Long Shen, Ana Claudia Torrecilhas, Xiaomei Yan, Fuquan Yang, Hang Yin, Yu Xiao, Zezhou Zhao, Xue Zou, Qian Wang & Lei Zheng (2020) The future of Extracellular Vesicles as Theranostics – an ISEV meeting report, Journal of Extracellular Vesicles, 9: (1) 1809766, DOI: 10.1080/20013078.2020.1809766
32. Bao-Hong Lee, She-Ching Wu, Tang-Long Shen, Yi-Yun Hsu, Chia-Hsiu Chen, Wei-Hsuan Hsu (2021) The applications of Lactobacillus plantarum-derived extracellular vesicles as a novel natural antibacterial agent for improving quality safety in tuna fish. Food Chem. 340:128104. doi: 10.1016/j.foodchem.2020.128104.
33. 陳昱宏，廖耕賢，沈湯龍 (2021)臺灣科技農企業進軍國際市場之價值戰略：運用非對稱垂直策略結盟與專屬獨賣模式創造優勢與利基．農業生技產業季刊 63: 1-10
34. Siou-Ru Shen, Wei-Jen Chen, Hui-Fang Chu, Shiuan-Huei Wu, Yu-Ru Wang, Tang- Long Shen (2021) Amelioration of 5-fluorouracil-induced intestinal mucositis by Streptococcus thermophilus ST4 in a mouse model. PLOS One 16(7):e0253540. doi: 10.1371/journal.pone.0253540
35. Li-Chun Chang, Yi-Chiung Hsu, Han-Mo Chiu, Koji Ueda, Ming-Shiang Wu, Chiun-How Kao, and Tang-Long Shen (2021) Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia. Front Oncol. 2021; 11: 732743. doi: 10.3389/fonc.2021.732743
36. Chang, Li-Chun, Han-Mo Chiu, Ming-Shiang Wu, and Tang-Long Shen (2022) The Role of Small Extracellular Vesicles in the Progression of Colorectal Cancer and Its Clinical Applications. International Journal of Molecular Sciences 23 (3): 1379. https://doi.org/10.3390/ijms23031379
37. Hong, SF., Fang, RY., Wei, WL., Jirawitchalert, S., Pan, ZJ., Hung YL., Pham TH., Chiu, YH., Shen, TL., Huang CK., Lin, SS. et al. (2023) Development of an assay system for the analysis of host RISC activity in the presence of a potyvirus RNA silencing suppressor, HC-Pro. Virol J 20, 10. https://doi.org/10.1186/s12985-022-01956-2
38. Bao-Hong Lee, You-Zuo Chen, Tang-Long Shen, Tzu-Ming Pan, Wei-Hsuan Hsu (2023) Proteomic characterization of extracellular vesicles derived from lactic acid bacteria. Food Chemistry 427: 136685
39. Zhang, B., Sim, W.K., Shen, TL. and Sai Kiang Lim. (2024) Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines. J Biomed Sci 31, 9 https://doi.org/10.1186/s12929-024-01000-1
40. Wei-Jen Chen, Yu-Shan Wei, Hsin-I. Lo, Hui-Fang Chu, Ming-Chung Tseng, Bao-Hong Lee, and Tang-Long Shen* (2024) Liquid-State Fermented Ganoderma lucidum GANO99 Regulates Gut Microbiota and Concomitantly Modulates the Behavioral Deficits and Neurohistopathological Hallmarks of Alzheimer’s Disease in a Preclinical Transgenic Mouse Model of Alzheimer’s Disease. Journal of Food Biochemistry Article ID 6676977. https://doi.org/10.1155/2024/6676977
41. Yasuhiro Shinkai, Yunjie Ding, Toru Matsui, George Devitt, Masahiro Akiyama, Tang-Long Shen, Motohiro Nishida, Tomoaki Ida, Takaaki Akaike, Sumeet Mahajan, Jon M. Fukuto, Yasuteru Shigeta, Yoshito Kumagai (2023) Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein. BioRxriv
42. Bao-Hong Lee, She-Ching Wu, Hao-Yuan Chien, Tang-Long Shen and Wei-Hsuan Hsu (2023) Tomato-fruit-derived extracellular vesicles inhibit Fusobacterium nucleatum via lipid- mediated mechanism. Food and Function., 14, 8942-895043. Bin Zhang, Wei Kian Sim, TangLong Shen and Sai Kiang Lim (2024) Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines. Journal of Biomedical Sciences 31:9
44. Shi Y-C, Zheng Y-J, Lin Y-C, Huang C-H, Shen T-L, Hsu Y-C, Lee B-H. Investigation of the Microbial Diversity in the Oryza sativa Cultivation Environment and Artificial Transplantation of Microorganisms to Improve Sustainable Mycobiota. Journal of Fungi. 2024; 10(6):412. https://doi.org/10.3390/jof10060412
45. Chuang WY, Lin YC, Shrestha B, Jennifer J, Stadler M, Tzean SS, Wu S, Ko CC, Hsieh SY, Wu ML, Wang SC, Shen TL*, Ariyawansa HA* (2024). Phylogenetic diversity and morphological characterization of cordycipitaceous species in Taiwan. Studies in Mycology 109: 1–56. doi: 10.3114/sim.2024.109.01 Received: 11 December 2023; Accepted: 8 April 2024
46. Pei-Yu Chu, Yu-Ling Tai, Ming-Yang Wang, Hsinyu Lee, Wen Hung Kuo, Tang-Long Shen* (2024) EGF-Activated Grb7 Confers to STAT3-Mediated EPHA4 Gene Expression in Regulating Lung Cancer Progression. Cancer Cell International (under revision)