SPEAKERS
Wen-Hao Ynag
AFFILIATION:
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
POSITION TITLE:
Assistant Professor
EDUCATION/TRAINING:
- Award recipient of the Ministry of Education's Flexible Salary Program for Outstanding
- Talents, Ministry of Education, Taiwan (2021-2024)
- 2022 China Medical University Outstanding Teacher, China Medical University, Taiwan (2023)
- YingTsai Young Scholar Award, China Medical University, Taiwan (2019)
- Nanshan Scholar Award, Guangzhou Medical University, China (2018)
- Awesome Job Award, MD Anderson Cancer Center, USA (2016)
- Award recipient of the Postdoctoral Research Abroad Program, Ministry of Science and Technology, Taiwan (2015).
- ·Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2013), Oral presentation in English.
- Award of Excellent Thesis, Office of Research and Development, National Yang-Ming University, Taiwan (2013), Oral presentation in English.
- Award of Honorable Research Project, 18th Taiwan Joint Cancer Conference, Shanghai, China (2013), Oral presentation in English.
- Award of the Best Research Thesis, Annual Distinguished Thesis of National Yang-Ming University, Taiwan (2012), Oral presentation in English.
- ward of Distinguished Thesis, Jung-Yaw Lin Academic Education Foundation, Taiwan (2012), Oral presentation in English.
- Award of Distinguished Research Project, 16th Taiwan Joint Cancer Conference, Taiwan (2011), Oral presentation in English.
- Award of Distinguished Research Project, 15th Taiwan Joint Cancer Conference, Taiwan (2010), Oral presentation in English.
HONORS:
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (2008 - 2012) Ph.D., Cancer Biology
Institute of Biochemistry, National Chung-Hsing University, Taichung, Taiwan (2002 - 2005) M.S., Biochemistry
Department of Environmental Engineering and Science, Feng-Chia University, Taichung, Taiwan (1998- 2002) B.S., Environmental Engineering
RESEARCH INTERESTS:
- T-cell dysfunctions in tumor microenvironment
- Targeting cancer stem cells
- Drug development of natural peptides and exosomes for human diseases
PUBLICATIONS:
1. Huang CH # , Yang WH # , Chang SY, Tai SK, Tzeng CH, Kao JY, Wu KJ and Yang MH. Regulation
of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
Neoplasia 2009;11:1371-82. # Equal contribution.
2. Yang MH # , Hsu DS # , Wang HW, Wang HJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH,
Tai SK, Chang SY, Lee OK and Wu KJ. BMI1 is essential in Twist1-induced epithelial-
mesenchymal transition. Nat Cell Biol. 2010;12:982-92.
3. Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC and Yang MH.
RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012; 14:366-74.
4. Yang WH, Lan HY, Tai SK and Yang MH. Repression of bone morphogenetic protein 4 by let-7i
attenuates mesenchymal migration of head and neck cancer cells. Biochemical and Biophysical
Research Communications 2013;433:24-30.
5. Yang WH and Yang MH. Three-dimensional Invasion Assay. Bio-Protocol. 2013; 3:e885.
6. Yang WH, Su YH, Hsu WH, Wang CC, Arbiser L. J and Yang MH. Imipramine blue halts head and
neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1
degradation. Oncogene 2016; 35:2287-98.
7. Wang S # , Liang K # , Hu Q # , Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang WH, Park PK,
Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores
ER, Sood AK, Huang S, Yu D, Yang L and Lin C. JAK2-binding Long Noncoding RNA Promotes
Breast Cancer Brain Metastasis. J Clin Invest. 2017; 127(12):4498-4515.
8. Wang YN # , Lee HH # , Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Ying H, Lim SO, Ye
Y, Ko HW, Wang WJ, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR, Katz MH, Fogelman D,
Fleming JB, Javle M, Maitra A and Hung MC. Angiogenin/ribonuclease 5 is an EGFR ligand and a
serum biomarker for erlotinib sensitivity in pancreatic cancer. Cancer Cell 2018; 33(4):752-769.
9. Chen YQ, Lan HY, Wu YC, Yang WH, Chiou A, Yang MH. Epithelial-mesenchymal transition
softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med.
2018; 22(8):3837-3846.
10. Yang WH # , Cha JH # , Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren GX and Hung MC.
Juxtacrine signaling inhibits antitumor immunity via upregulating PD-L1. Cancer Research 2018;
78(14):3761-3768. Equal contribution.
11. Hsieh HJ # , Zhang W # , Lin SH, Yang WH, Wang JZ, Shen J, Zhang Y, Lu Y, Wang H, Yu J, Mills
GB and Peng G. Systems biology approach reveals a link between mTORC1 and G2/M DNA
damage checkpoint recovery. Nature Communications 2018; 9(1):3982.
12. Lee PC*, Fang YF*, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z,
Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT,
Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L, Fang
B, Chen T, Wong KK, Hsu JL and Hung MC. Targeting PKCδ as a Therapeutic Strategy against
Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer
Cell 2018; 34(6):954-969.e4.
13. Cha JH # , Yang WH # , Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu J,
Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK,
Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo
KH and Hung MC. Metformin promotes antitumor immunity via endoplasmic reticulum-associated
degradation of PD-L1. Molecular Cell 2018; 71(4):606-620.e7. # Equal contribution.
14. Chen R # , Yuan L # , Cao N # , Li P, Chen H, Zhou J, Hao X, Liu T, Yang WH, Cui S* and Yan X*. An
immunosuppressive peptide from the horsefly inhibits inflammation by repressing macrophage
maturation and phagocytosis. Journal of Cellular Biochemistry 2019; 120(8):14116-14126.
15. Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC,
Zha Z, Lim SO, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q,
Hassan MM, Amin HM, Kaseb AO, Xin Lin X, Wang SC and Hung MC. IL-6/JAK1 pathway drives
PD-L1 Y112 phosphorylation to promote cancer immune evasion. Journal of Clinical Investigation
2019; 129(8):3324-3338.
16. Yan X # , Cao N # , Chen Y # , Lan HY, Cha JH, Yang WH* and Yang MH*. MT4-MMP promotes
invadopodia formation and cell motility in FaDu head and neck cancer cells. Biochemical and
Biophysical Research Communications 2020; 522(4):1009-1014. *Correspondence authors.
17. Chen B # , Ye P # , Chen Y # , Liu T, Cha JH, Yan X* and Yang WH*. Involvement of the Estrogen and
Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical
Significance. Frontiers in Oncology 2020, 10:1657. *Correspondence authors.
18. Wang YC # , Yang WH # , Yang CS, Tsai CL, Chou YZ, Hung MC* and Chen Y*. Structural basis of
SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug. American
Journal of Cancer Research 2020, 10(8):2535-2545. # Equal contribution.
19. Kim KJ, Yang WH, Jung YS, Cha JH. A new aspect of an old friend: the beneficial effect of
metformin on anti-tumor immunity. BMB Reports 2020, 53(10):512-520.
20. Chen Y # , Yang WH # , Huang LM, Wang YC, Yang CS, Liu YL, Hou MH, Tsai CL, Chou YZ,
Huang BY, Hung CF, Hung YL, Chen JS, Chiang YP, Cho DY, Jeng LB, Tsai CH and Hung MC.
Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in
vitro. BioRxiv 2020. # Equal contribution.
21. Gao S, Jiang J, Jin C, Gao J, Xiong D, Yang P, Cui S, Yang WH, Leng Q, Dong J, Chen G, Liu J,
Li Wang, Ke A, Wang H and Ding J. Interleukin-8 as a candidate for thymoma identification and
recurrence surveillance. Nature Communications 2020; 11, 4881.
22. Lee HH # , Wang YN # , Yang WH # , Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y,
Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang
SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D and Hung MC.
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor
initiation. Nature Communications 2021 May; 12, 2788. # Equal contribution. Recommended in
Faculty Opinions as being of special significance in its field; Selected as a featured article in the
Nature Communications Editors’ Highlights. https://www.cmu.edu.tw/news_detail.php?id=4868
23. Chen B # , Cha JH # , Yan M # , Cao N, Ye P, Yan X* and Yang WH*. ATXN7L3B promotes
hepatocellular carcinoma stemness and is downregulated by metformin. Biochemical and
Biophysical Research Communications 2021 Oct 6;573:1-8. *Correspondence authors.
24. Ye P # , Chi X # , Cha JH # , Luo S, Yang G, Yan X* and Yang WH*. Potential of E3 Ubiquitin Ligases
in Cancer Immunity: Opportunities and Challenges. Cells 2021 Nov 25; 10(12), 3309.
*Correspondence authors.
25. Yamaguchi H # , Hsu JM # , Yang WH # , Hung MC*. Mechanisms regulating PD-L1 expression in
cancers and associated opportunities for novel small-molecule therapeutics. Nature Reviews Clinical
Oncology 2022 May; 19(5):287-305. # Equal contribution.
26. Chen Y # , Yang WH # , Chen HF # , Huang LM # , Gao JY # , Lin CW, Wang YC, Yang CS, Liu YL, Hou
MH, Tsai CL, Chou YZ, Huang BY, Hung CF, Hung YL, Wang WJ, Su WC, Kumar V, Wu YC,
Chao SW, Chang CS, Chen JS, Chiang YP, Cho DY, Jeng LB, Tsai CH, Hung MC. Tafenoquine and its derivatives as inhibitors for the Severe Acute Respiratory Syndrome Coronavirus 2. Journal
of Biological Chemistry 2022 Mar; 298(3), 101658. # Equal contribution.
27. Cha JH # , Chan LC # , Wang YN # , Chu YY # , Wang CH # , Lee HH, Xia W, Shyu WC, Liu SP, Yao J,
Chang CW, Cheng FR, Liu J, Lim SO, Hsu JL, Yang WH, Hortobagyi GN, Lin R, Yang L, Yu D,
Jeng LB*, Hung MC*. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen
receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer.
Journal of Biological Chemistry 2022 Apr; 298(4), 101817.
28. Ye P # , Chi X # , Yan X # , Wu F, Liang Z, Yang WH*. Alanine-glyoxylate aminotransferase sustains
cancer stemness properties through the upregulation of SOX2 and OCT4 in hepatocellular carcinoma
cells. Biomolecules 2022 May; 12(5), 668.
29. Luo S # , Yang G # , Ye P # , Cao N, Chi X, Yang WH*, Yan X*. Macrophage is a double-edged sword:
Molecular Crosstalk between Tumor-associated Macrophages and Cancer Stem Cells. Biomolecules
2022 Jun; 12(6), 850. *Correspondence authors.
30. Lin WC # , Lin CC # , Lin YY, Yang WH, Twu YC, Teng HW* and Hwang WL*. Molecular Actions
of Exosomes and Their Theragnostics in Colorectal Cancer: Current Findings and Limitations.
Cellular Oncology 2022 Dec; 45(6):1043-1052.
31. Fang M # , Cha JH # , Wang HC, Ye P, Chen Bi, Chen M, Yang WH* and Yan X*. An undefined
cystatin CsCPI1 from tea plant Camellia sinensis harbors antithrombotic activity. Biomedicine &
Pharmacotherapy 2023 Mar; 159:114285. *Correspondence authors.
32. Chi X # , Luo S # , Ye P # , Hwang WL, Cha JH*, Yan X* and Yang WH*. T-cell exhaustion and
stemness in antitumor immunity: characteristics, mechanisms, and implications. Frontiers in
Immunology 2023 Feb; 14:1104771. *Correspondence authors.
33. Choi MJ # , Shin J # , Lee CE # , Chung JY, Kim M, Yan X*, Yang WH* and Cha JH*. Immunogenic
cell death in cancer immunotherapy. BMB Reports 2023 May;56(5):275-286. *Correspondence
authors.
34. Peng PH # , Chen JL # , Wu HH # , Yang WH # , Lin LJ, Lai Joseph CY, Chang JS, Syu JL, Wu HT, Hsu
FT*, Cheng WC* and Hsu KW*. Interplay between lncRNA RP11-367G18.1 variant 2 and YY1
plays a vital role in hypoxia-mediated gene expression and tumorigenesis. Cancer Cell
International. 2023 Nov;23(1):266. # Equal contribution.