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Wei-Chien Huang

AFFILIATION:

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

POSITION TITLE:

Professor

EDUCATION/TRAINING:

2006/04~2007/11

Postdoc. Department of Molecular and Cellular Oncology, UT. M.D. Anderson Cancer Center, Houston, TX, USA

2003/04~2006/03

Postdoc. Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

2000/09~2003/03

Ph.D. Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

1998/09~2000/06

 

1989/09~1995/06  

Master. Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan

 

Bachelor. Department of Pharmacy, Tajen University, Pingtung, Taiwan

 

HONORS:

  1. Teacher Award for Outstanding Teaching Performance, College of Medicine, China Medical University 2012
  2. Young Scholar Award for Medical Research, Professor C. Y. Lee Foundation，2007.11.10
  3. Young Research Scholar Award, The Pharmacological Society in Taiwan, 2006.03.18
  4. Excellent Ph.D. thesis Award of Wang Ming-Ning Memorial Foundation, Wang Ming-Ning Memorial Foundation, 2004.12.15
  5. Taiwan Merit Scholarship (菁英計畫), MOE, 2006~2007
  6. Postdoctoral Fellowship Award, NHRI, 2005.01.01~2006.12.31
  7. Graduate Travel Award，American Society for Biochemistry and Molecular Biology, 2004.03.12

RESEARCH INTERESTS:

  • Pharmacology

  • Target therapy

  • Drug resistance

  • Cancer Metabolism

  • Tumor immunology

  • Cancer stem cells

  • Caner epigenetics

  • Cancer Pharmacology

PUBLICATIONS:

Selected Publications

  1. Huang H.-Y., Chen C.-H., Cheng F.-J., Wang B.-W., Tu C.-Y., Chen Y.-J., He Y.-H.#, Yao C.-H.#, and Huang W.-C.# Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer. Journal of Hazardous Materials. In press. 2024
  2. Ho C.-Y., Wei C.-Y., Zhao R.-W., Ye Y.-L., Huang H.-C., Lee J.-C., Cheng, F.-J.#, Huang W.-C.#. Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2-positive breast cancer. Environ Toxicol. 2024 Jun;39(6):3389-3399.
  3. Jiang Y.-J., Chao C.-C., Chang A.-C., Chen P.-C., Cheng F.-J., Liu J.-F., Liu P.-I., Huan C-L., Guo J.-H., Huang W.-C.#, and Tang C.-H#. Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis. Journal of Advanced Research. Journal of Advanced Research. 2022, 2022 Nov; 41: 77–87.
  4. Nguyen K, Chiou J.-Y., Liu Y.-C., Cheng F.-J., Shen Y.-C., Chen C.-J., Tang C.-H., Chen C.-H., Tu C.-Y., and Huang W.-C. L-lactic acidosis confers the insensitivity to PKC inhibitors by competing for the uptake via monocarboxylate transporter. J Cellular Physiology. 2022, 237(1):934-948.
  5. Cheng F-J, Chen C-H, Tsai W-C, Wang B-W, Yu M-C, Hsia T-C, Wei Y-L, Hsiao Y-C, Hu D-W, Ho C-Y, Li T-S, Wu C-Y, Chou W-Y, Yu Y-L, Tang C-H, Chen C-Y, Chen C-M, Hsu JL, Chen H-F, Chen Y, Tu C-Y, Hung M-C, Huang W-C. Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC. Oncogene 2021; 40: 1162-1175.
  6. He Y.-H., Yeh M.-H., Chen H.-F., Wang T.-S., Wong R.-H., Wei Y.-L., Huynh T.-K., Hu D.-W., Cheng F.-J., Chen J.-Y., Hu S.-W, Huang C.-C., Chen Y., Yu J., Cheng W.-C., Shen P.-C., Liu L.-C., Huang C.-H., Chang Y.-J., and Huang W.-C. ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions. Molecular Therapy-Nucleic Acids. 2021, 25:536-553.
  7. Chen C-H, Wang B-W, Hsiao Y-C, Wu C-Y, Cheng F-J, Hsia T-C, Chen C-Y, Wang Y, Weihua Z, Chou R-H, Tang C-H, Chen Y-J, Wei Y-L, Hsu JL, Tu C-Y, Hung M-C, Huang W-C. PKC delta-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. Oncogene 2021.
  8. Huynh T.K, Huang C.-H., Chen J.-Y., Yao J.-H., Yang Y.-S., Wei Y.-L., Chen H.-F., Chen C.-H., Tu C.-Y., Hsu Y.-M., Liu L.-C., Huang W.-C. MiR-221 confers lapatinib resistance by negatively regulating p27kip1 in HER2-positive breast cancer. Cancer Science. 2021; 10: 4234-4245
  9. Cheng F.-J., Huynh T.K., Yang C.-S., Hu D.-W, Wu Y.-C., Tang C.-H., Chen Y, Huang W.-C. Hesperidin is a potential inhibitor against SARS-CoV-2 infection. Nutrients. 16;13(8):2800
  10. Wang B-W, Huang C-H, Liu L-C, Cheng F-J, Wei Y-L, Lin Y-M, Wang Y-F, Wei C-T, Chen Y, Chen Y-J, Huang W-C. Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2. Frontiers in Pharmacology 2021; 12.
  11. Tu C-Y, Wang B-W, Cheng F-J, Chen C-H, Hsia T-C, Wei Y-L, Chen C-Y, Hsieh IS, Yeh Y-L, Wang L-Y, Chen C-M, Chang W-C, Huang W-C. Incense burning smoke sensitizes lung cancer cells to EGFR TKI by inducing AREG expression. American Journal of Cancer Research 2018; 8: 2575.
  12. Tu C-Y, Cheng F-J, Chen C-M, Wang S-L, Hsiao Y-C, Chen C-H, Hsia T-C, He Y-H, Wang B-W, Hsieh IS, Yeh Y-L, Tang C-H, Chen Y-J, Huang W-C. Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs. Molecular Oncology 2018; 12: 705-723.
  13. Tung J-C, Huang W-C, Yang J-C, Chen G-Y, Fan C-C, Chien Y-C, Lin P-S, Lung S-CC, Chang W-C. Auramine O, an incense smoke ingredient, promotes lung cancer malignancy. Environmental Toxicology 2017; 32: 2379-2391.
  14. Chen C-H, Hsia T-C, Yeh M-H, Chen T-W, Chen Y-J, Chen J-T, Wei Y-L, Tu C-Y, Huang W-C. MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK-mediated HER2 phosphorylation at Thr701. Molecular Oncology 2017; 11: 1273-1287.
  15. Huang W-C, Hung C-M, Wei C-T, Chen T-M, Chien P-H, Pan H-L, Lin Y-M, Chen Y-J. Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells. Oncotarget 2016; 7: 62352-62363.
  16. Chen W-S, Liu L-C, Yen C-J, Chen Y-J, Chen J-Y, Ho C-Y, Liu S-H, Chen C-C, Huang W-C. Nuclear IKK alpha mediates microRNA-7/-103/107/21 inductions to downregulate maspin expression in response to HBx overexpression. Oncotarget 2016; 7: 56309-56323.
  17. Chen J-Y, Chen Y-J, Yen C-J, Chen W-S, Huang W-C. HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3. Oncotarget 2016; 7: 473-489.
  18. Hsiao Y-C, Yeh M-H, Chen Y-J, Liu J-F, Tang C-H, Huang W-C. Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6. Oncotarget 2015; 6: 37965-37978.
  19. Chen W-S, Yen C-J, Chen Y-J, Chen J-Y, Wang L-Y, Chiu S-J, Shih W-L, Ho C-Y, Wei T-T, Pan H-L, Chien P-H, Hung M-C, Chen C-C, Huang W-C. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. Oncotarget 2015; 6: 25962-25974.
  20. Tu C-Y, Chen C-H, Hsia T-C, Hsu M-H, Wei Y-L, Yu M-C, Chen W-S, Hsu K-W, Yeh M-H, Liu L-C, Chen Y-J, Huang W-C. Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells. Biomed Research International 2014; 2014.
  21. Huang W-C, Hung M-C. Beyond NF-kappa B activation: nuclear functions of I kappa B kinase alpha. Journal of Biomedical Science 2013; 20.
  22. Huang W-C, Hsu S-C, Huang S-J, Chen Y-J, Hsiao Y-C, Zhang W, Fidler IJ, Hung M-C. Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis. American Journal of Translational Research 2013; 5: 441-449.
  23. Huang W-C, Hsieh Y-L, Hung C-M, Chien P-H, Chien Y-F, Chen L-C, Tu C-Y, Chen C-H, Hsu S-C, Lin Y-M, Chen Y-J. BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib. Plos One 2013; 8.
  24. Hsia T-C, Tu C-Y, Chen Y-J, Wei Y-L, Yu M-C, Hsu S-C, Tsai S-L, Chen W-S, Yeh M-H, Yen C-J, Yu Y-L, Huang T-C, Huang C-Y, Hung M-C, Huang W-C. Lapatinib-Mediated Cyclooxygenase-2 Expression via Epidermal Growth Factor Receptor/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells. Molecular Pharmacology 2013; 83: 857-869.
  25. Chen Y-J, Yeh M-H, Yu M-C, Wei Y-L, Chen W-S, Chen J-Y, Shih C-Y, Tu C-Y, Chen C-H, Hsia T-C, Chien P-H, Liu S-H, Yu Y-L, Huang W-C. Lapatinib-induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors. Breast Cancer Research 2013; 15.
  26. Huang W-C, Chen W-S, Chen Y-J, Wang L-Y, Hsu S-C, Chen C-C, Hung M-C. Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-Dependent phosphorylation to promote the motility of hepatocarcinoma cells. Journal of Cellular Physiology 2012; 227: 1446-1454.
  27. Huang W-C, Chen Y-J, Li L-Y, Wei Y-L, Hsu S-C, Tsai S-L, Chiu P-C, Huang W-P, Wang Y-N, Chen C-H, Chang W-C, Chang W-C, Chen AJ-E, Tsai C-H, Hung M-C. Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells. Journal of Biological Chemistry 2011; 286: 20558-20568.
  28. Chen Y-J, Huang W-C, Wei Y-L, Hsu S-C, Yuan P, Lin HY, Wistuba II, Lee JJ, Yen C-J, Su W-C, Chang K-Y, Chang W-C, Chou T-C, Chou C-K, Tsai C-H, Hung M-C. Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells. Plos One 2011; 6.
  29. Yang P-M, Huang W-C, Lin Y-C, Huang W-Y, Wu H-A, Chen W-L, Chang Y-F, Chou C-W, Tzeng C-C, Chen Y-L, Chen C-C. Loss of IKK beta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. Journal of Cellular and Molecular Medicine 2010; 14: 687-698.
  30. Huang W-C, Ju T-K, Hung M-C, Chen C-C. Phosphorylation of CBP by IKK alpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappa B. Molecular Cell 2007; 26: 75-87.
  31. Huang W-C, Chen CC. Akt-phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Molecular and Cellular Biology 2005; 25: 6592-6602.
  32. Chen JJ, Huang W-C, Chen CC. Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein delta and CREB-binding protein. Molecular Biology of the Cell 2005; 16: 5579-5591.
  33. Huang W-C, Chan ST, Yang TL, Tzeng CC, Chen CC. Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives. Carcinogenesis 2004; 25: 1925-1934.
  34. Huang W-C, Chen JJ, Inoue H, Chen CC. Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. Journal of Immunology 2003; 170: 4767-4775.
  35. Huang W-C, Chen JJ, Chen CC. c-Src-dependent tyrosine phosphorylation of IKK beta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. Journal of Biological Chemistry 2003; 278: 9944-9952.