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Shih-Hsien Hsu

AFFILIATION:

Graduate Institute of Medicine, Kaohsiung Medical University , Kaohsiung, Taiwan

POSITION TITLE:

Professor

EDUCATION/TRAINING:

PhD, 1996-2001 National Defense Medical Center, Taipei, Taiwan, 

(Laboratory: Dr. Hung Li (Institute of Molecular Biology, Academia Sinica.)

 

HONORS:

  1. 2000-2001, 2007, and 2010. Excellent Poster Award, 8th-9th, 15th, 25th Symposium on Recent Advences in Cellular and Molecular Biology.
  2. 2013-2014. Travel Grant award, 72nd -73rd Annual Meeting of The Japanese Cancer Association (JCA). 
  3. 2011, 2013-2014, 2018-2021 Outstanding Research award, Kaohsiung Medical University
  4. 2014 Liver Disease Prevention Research Foundation Fellowship.
  5. 2018. Annual excellent research project funding, Kaohsiung Medical University.
  6. 2018, 2120-2022 Special Outstanding Talents of the Ministry of Science and Technology Awards, Ministry of Science and Technology (MOST), R.O.C., Taiwan.
  7. 2022, Dr. Tung Ta-Cheng’s Basic Cancer Research Award.
  8. 2022, Merit Pay Implementation Program for Recruiting and Retaining Special, Outstanding, and Talented Faculty Members for Taiwanese Universities, Ministry of Education (MOE), Taiwan, ROC.

RESEARCH INTERESTS:

PUBLICATIONS:

[1] J.S. Du, S.H. Hsu, S.N. Wang, The Current and Prospective Adjuvant Therapies for Hepatocellular Carcinoma, Cancers (Basel), 16 (2024).

[2] Y.M. Liao, S.H. Hsu, S.S. Chiou, Harnessing the Transcriptional Signatures of CAR-T-Cells and Leukemia/Lymphoma Using Single-Cell Sequencing Technologies, Int J Mol Sci, 25 (2024).

[3] P.C. Lin, W.Y. Hsu, P.Y. Lee, S.H. Hsu, S.S. Chiou, Insights into Hepatocellular Carcinoma in Patients with Thalassemia: From Pathophysiology to Novel Therapies, Int J Mol Sci, 24 (2023).

[4] L.T. Wang, K.Y. Liu, S.N. Wang, M.H. Lin, Y.M. Liao, P.C. Lin, S.K. Huang, S.H. Hsu, S.S. Chiou, Aryl hydrocarbon receptor-kynurenine axis promotes oncogenic activity in BCP-ALL, Cell Biol Toxicol, 39 (2023): 1471-1487.

[5] L.T. Wang, S.N. Wang, S.S. Chiou, J.P. Tsai, C.Y. Chai, L.W. Tseng, J.C. Lee, M.H. Lin, S.K. Huang, S.H. Hsu, HCV Core Protein-ISX Axis Promotes Chronic Liver Disease Progression via Metabolic Remodeling and Immune Suppression, Adv Sci (Weinh), (2023): e2300644.

[6] K.T. Chuang, S.S. Chiou, S.H. Hsu, Recent Advances in Transcription Factors Biomarkers and Targeted Therapies Focusing on Epithelial-Mesenchymal Transition, Cancers (Basel), 15 (2023): p3338.

[7] M.L. Tsai, S.H. Hsu, L.T. Wang, W.T. Liao, Y.C. Lin, C.H. Kuo, Y.L. Hsu, M.C. Feng, F.C. Kuo, C.H. Hung, Di(2-ethylhexyl) phthalate mediates IL-33 production via aryl hydrocarbon receptor and is associated with childhood allergy development, Front Immunol, 14 (2023): 1193647.

[8] L.T. Wang, K.Y. Liu, S.S. Chiou, S.K. Huang, S.H. Hsu, S.N. Wang, Phosphorylation of intestine-specific homeobox by ERK1 modulates oncogenic activity and sorafenib resistance, Cancer Lett, 520 (2021): 160-171.

[9] L.T. Wang, M.H. Lin, K.Y. Liu, S.S. Chiou, S.N. Wang, C.Y. Chai, L.W. Tseng, H.C. Chiou, H.C. Wang, K.K. Yokoyama, S.H. Hsu, S.K. Huang, WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism, Autophagy, 17 (2021): 4202-4217.

[10] K.Y. Liu, L.T. Wang, H.C. Wang, S.N. Wang, L.W. Tseng, C.Y. Chai, S.S. Chiou, S.K. Huang, S.H. Hsu, Aryl Hydrocarbon Receptor is Essential in the Control of Lung Club Cell Homeostasis, J Inflamm Res, 14 (2021): 299-311.

[11] L.T. Wang, K.Y. Liu, W.Y. Jeng, C.M. Chiang, C.Y. Chai, S.S. Chiou, M.S. Huang, K.K. Yokoyama, S.N. Wang, S.K. Huang, S.H. Hsu, PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition, EMBO Rep, 21 (2020): e48795.

[12] L.T. Wang, S.N. Wang, S.S. Chiou, K.Y. Liu, C.Y. Chai, C.M. Chiang, S.K. Huang, K.K. Yokoyama, S.H. Hsu, TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial-mesenchymal transition and metastasis in liver cancer, Oncogene, 38 (2019): 518-532.

[13] K.Y. Liu, L.T. Wang, S.H. Hsu, S.N. Wang, Homeobox Genes and Hepatocellular Carcinoma, Cancers (Basel), 11 (2019).

[14] K.Y. Liu, L.T. Wang, S.H. Hsu, Modification of Epigenetic Histone Acetylation in Hepatocellular Carcinoma, Cancers (Basel), 10 (2018).

[15] L.T. Wang, S.S. Chiou, C.Y. Chai, E. Hsi, K.K. Yokoyama, S.N. Wang, S.K. Huang, S.H. Hsu, Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression, Cancer Res, 77 (2017): 4065-4077.

[16] L.T. Wang, S.S. Chiou, C.Y. Chai, E. Hsi, S.N. Wang, S.K. Huang, S.H. Hsu, Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma, Oncotarget, 8 (2017): 7489-7501.

[17] L.T. Wang, S.S. Chiou, C.Y. Chai, E. Hsi, C.M. Chiang, S.K. Huang, S.N. Wang, K.K. Yokoyama, S.H. Hsu, Transcription factor SPZ1 promotes TWIST-mediated epithelial-mesenchymal transition and oncogenesis in human liver cancer, Oncogene, 36 (2017): 4405-4414.

[18] S.H. Hsu, L.T. Wang, C.Y. Chai, C.C. Wu, E. Hsi, S.S. Chiou, S.N. Wang, Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression, Mol Carcinog, 56 (2017): 2167-2177.