SPEAKERS
Jer-Yen Yang
AFFILIATION:
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
POSITION TITLE:
Associate Professor
EDUCATION/TRAINING:
1991 - 1995 B.S. in Plant Pathology, National Chung-Hsing University, Taiwan
1995 - 1997 M.S. in Biotechnology, National Taiwan Ocean University, Taiwan
Thesis Advisor: Jen-Lieh Wu, Ph.D.
Thesis: Transfer and expression of exogenous genes in zebrafish (Danio rerio): Green
fluorescence protein (Aequorea victoria) and Tilapia Insulin-like growth factor I
2004 - 2009 Ph.D. in Cancer Biology and Pharmacology, University of Texas M D Anderson Cancer Center,
Houston, Texas
Thesis Advisor: Mien-Chie Hung, Ph.D.
Thesis: A new fork for clinical application: targeting forkhead transcription factors in cancer
HONORS:
2008 Cancer Biology Program Retreat Oral Presentation 1st Place Award, MD Anderson Cancer Center
2008 Society of Chinese Bioscientists in America (SCBA) Oral Presentation 1st Place Award and
Professor Alexander Yeu-Ming Wang Memorial Scholarship
2008 GSBS Student Travel Award, MD Anderson Cancer Center
2009 Andrew Sowell-Wade Huggins Scholarship, MD Anderson Cancer Center
2009 Cancer Biology Program Retreat Oral Presentation 1st Place Award, MD Anderson Cancer Center
2009 GSBS Student Travel Award, MD Anderson Cancer Center
2010 Howard Hughes Medical Institute Postdoctoral Fellowship, Stanford University
2010 - 2011 NIH Tumor Biology Program, Training Fellowship, Stanford University
2011 - 2012 Lucile Packard Foundation for Children’s Health Award.
2013 American Cancer Society (ACS) Institutional Grant Award.
2014 Showalter Trust Fund Award.
2015 Elsa U. Pardee Foundation Cancer Research Award.
2018 Purdue Institute for Drug Discovery award, Purdue University
RESEARCH INTERESTS:
PUBLICATIONS:
1. Hong JR, Lin TL, Yang JY, Hsu YL, Wu JL. Dynamics of nontypical apoptotic morphological changes visualized by green fluorescent protein in living cells with infectious pancreatic necrosis virus
infection. Journal of Virology. 1999 Jun;73(6):5056-63.
2. Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H,
Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead
FOXO3a. Cell. 2004 Apr 16;117(2):225-37.
3. Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to
stabilize tumor suppressor p53. Cancer Research. 2004 Dec 15;64(24):9080-5.
4. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin
J, Lai CC, Tsai FJ, Tsai CH, Hung MC. Erk associates with and primes GSK-3beta for its inactivation
resulting in upregulation of beta-catenin. Molecular Cell. 2005 Jul 22;19(2):159-70.
5. Yang JY, Xia W, Hu MC. Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim,
and induces cell apoptosis. Int J Oncol. 2006 Sep;29(3):643-8.
6. Yang JY*, Zong CS*, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2
promotes cell motility and invasiveness by regulating E-cadherin degradation. Molecular & Cellular
Biology. 2006 Oct;26(19):7269-82. (*Co-first author)
7. Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid
cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with
poor prognosis in human breast cancer. Cancer Research. 2007 May 15;67(10):4564-71
8. Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell.2007 Aug 10;130(3):440-55.
9. Tsai KL, Sun YJ, Huang CY, Yang JY, Hung MC, Hsiao CD Crystal structure of the human FOXO3a DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Research. 2007;35(20):6984-94.
10. Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC et al., ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature Cell Biology. 2008 Feb;10(2):138-48 (Selected as hi-lite article in News and Views, Nature Cell Biology 10, 125 - 126).
11. Yang JY*, Ding Q*, Huo L*, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, Tsai FJ, Li LY, Tsai CH, Hung MC. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Research. 2008 Aug 1;68(15):6109-17. (*Co-first author)
12. Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in
cancer. Clinical Cancer Research. 2009 Feb 1;15(3):752-7. Review. (Invited review)
13. Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY,Yen CJ, Huang TH, Tan M, Xing G, Zhao Y, Lin CH, Tsai SF, Fidler IJ, Hung MC. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science Signaling. 2010 Feb:3(108):ra9.
14. Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC,
Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase
kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via
BH3-only proteins Puma and Bim. Cancer Research. 2010 Mar 15;70(6):2424- 34.
15. Yang JY*, Chang CJ*, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular
signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Research. 2010
Jun 1;70(11):4709-18. (*Co-first author)
16. Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB,
Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium
delays mammary involution and accelerates mammary tumorigenesis. Cancer Research. 2010 Oct
;70(19):7684-9.
17. Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochem Biophys Res Commun. 2010 Dec 3;403(1):103-7.
18. Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nature Cell Biology. 2011 Jan;13(1):87-94
19. Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell. 2011 Jan 18;19(1):86-100.
20. Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell propertiesthrough modulating miRNAs. Nature Cell Biology. 2011 Mar;13(3):317-23.
21. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ, Li CW, Jeng LB, Hsu JL, Li LY, Tan A, Curley SA, Ellis LM, Dubois RN, Hung MC. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis (2011) J Clin Invest. 2011 Nov;121(11):4526-36.
22. Yang JY and Hung MC. Deciphering and targeting Forkhead Transcriptional Factors in Cancer Therapy. Current Drug Targets. 2011 Aug;12(9):1284-90. (Invited review)
23. Zhang GJ, Vemulapalli TH, Yang JY (2013) Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. Applied & Translational Genomics http://dx.doi.org/10.1016/j.atg.2013.06.002
24. Chao CH, Chang CC, Wu MJ, Wang D, Hung MC, Yang JY, Chang CJ. Dysregulated miR-205 signaling promotes symmetric division of self-renewing mammary stem cells and mammary tumorigenesis (2014) J Clin Invest. Jul 1;124(7):3093-106.
25. Wu PC, Lu JW, Yang JY, Lin IH et.al. H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis. (2014) Cancer Research 15; 74 (24):7333-43.
26. Zhang GJ, YANG JY, Cui Z. New Insight into Cancer Aneuploidy in Zebrafish (2015) Int Rev Cell Mol Biol.; 314:149-70. (Invited review)
27. Chang CC, Wu MJ, Yang JY, Camarillo IG, Chang CJ. Leptin-STAT3-G9a Signaling Promotes Obsity-Mediated Breast Cancer Progression. Cancer Res. 2015 Jun 1;75(11):2375-86.
28. Li YH, Luo J, Mosley C YY, Hedrick VE, Paul LN, Chang J, Zhang G, Wang YK, Banko MR, Brunet A, Kuang S, Wu JL, Chang CJ, Scott MP, Yang JY. AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcrition Factor GLI1 in Medulloblastoma. Cell Rep. 2015 Jul 28;12(4):599-609.
29. Huang SY and Yang JY. Targeting the Hedgehog Pathway in Pediatric Medulloblastoma. Cancers 2015 Oct 23;7(4):2110-23.
30. Zhang X, Li J, Yang JY, Wood KV, Rothwell AP, Li W, Blatchley Iii ER. Chlorine/UV Process for Decomposition and Detoxification of Microcystin-LR. Environ Sci Technol. 2016 Jul 19;50(14):7671-8. PMID: 27338715
31. Hensley MR, Cui Z, Chua RF, Simpson S, Shammas NL, Yang JY, Leung YF, Zhang G. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Sci Rep. 2016 Jun 13;6:27816. PMID: 27292017
32. Hensley, M., Chua R., Cui, Z.B., Yang, JY, Zhang, G. Molecular evolution of MDM1 family genes. 2016, Plos One 2016 Sep 22;11(9):e0163229. doi: 10.1371/journal.pone.0163229.
33. Cui Z, Shen Y, Chen KH, Mittal SK, Yang JY, Zhang G. KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors. Sci Rep. 2017 Jan 9;7:40325.
34. Wu MJ, Kim MR, Chen YS, Yang JY, Chang C-J (2017) Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway. Oncogene doi: 10.1038/onc.2016.467.
35. Zhang, R., Huang, S.Y., Li, K., Zhang G, Chang CJ, and Yang, JY. (2017) Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget. Jul 25;8(30):49869-49881.
36. Huang, S.Y., Chen, S.,K.,Yang, JY (2017) Activation of AMPKinhibits medulloblastoma cell growth and Gli1 activity. Cancer Reports and Reviews Nov. 30 Vol 2(1):1-4.
37. Kumari R, Silic MR, Jones-Hall YL, Nin-Velez A, Yang JY, Mittal SK, Zhang G. (2018) Identification ofRECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath . Oncotarget. May 4;9(34):23494-23504.
38. Wu MJ, Chen YS, Kim MR, Chang CC, Gampala S, Zhang Y, Wang Y, Chang CY, Yang JY, Chang CJ. (2018) Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Cell Metabolism 2018 Nov 27. PMID:30527740
39. Kim MR, Wu MJ, Zhang Y, Yang JY*, Chang CJ*. (2020) TET2 directs mammary luminal cell differentiation and endocrine response. Nature Communications volume 11, Article number: 4642
40. Gampala S, Zhang G, Chang CJ, Yang JY*. Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib- resistance. FASEB BioAdvances (2021) 00:1–11.
41. Gampala S and Yang JY*. Hedgehog Pathway Inhibitors against Tumor Microenvironment. Cells. 2021,10(11), 3135
42. Gu X, He M, Lebedev T, et al., Yang JY and Li XG. PRMT1 is an important factor for
medulloblastoma cell proliferation and survival. Biochemistry and Biophysics Reports (2022) Volume 32, December 2022, 101364
43. Gumilar KZ, Chin Y, Ibrahim HI, Tjokroprawiro BA, Yang JY, Zhou M, Gassman NR, Tan M *HSF1
Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology. Cancers (2023) Oct
27;15(21):5167.
44. Zhang Y*, Wu MJ, Liu WC, Li YC, Chang CJ* and Yang JY*. Metabolic switch regulates lineage
plasticity and induces synthetic lethality in triple-negative breast cancer. Cell Metabolism (2024) Jan
2;36(1):193-208.e8.