Speaker

AFFILIATION:

Taipei Medical University, Taipei, Taiwan

POSITION TITLE:

Professor and Academician

EDUCATION/TRAINING:

 

HONORS:

1. 0.05% Top Scientists in ScholarGPS world ranking
2. NCI Merit Award (CA39207) 
3. NCI Merit Award (CA46613)
4. NIH Norman Salzman Lectureship, 2012
5. Academia Sinica Academician, Taiwan, ROC
6. Auburn Community Cancer Endowment Chair in Basic Science, UC Davis 2007
7. Joan Oettinger Memorial Award in Lung and Cancer Research, 2006
8. Society of American Asian Scientists in Cancer Research (SAASCR), recipient of annual award-2006
9. UC Davis School of Medicine Faculty Research Award, 2005
10. Goodman-Blum Professor in Cancer Research, CWRU
11. Honorary Distinguished Fellow, NHRI, Taiwan
12. Lifetime Distinguished Professor, NYCU
13. Faculty Research Award, American Cancer Society, 1983-1987
14. Gordon Conference on Personalized Medicine, Co-Chair and Vice Chair, 2018-2020
15. Keystone Symposium, Co-organizer and Chair, 2004

RESEARCH INTERESTS:

My lab has contributed to our understanding of oncogenes, signal transduction, viral oncogenesis, cancer metabolism and epigenetics. We were credited for the original discovery of dimer structure of retrovirus genome (Cell, 1976), erbB/EGFR as a target gene for retroviral insertion (Cell, 1983, 1986, 1993, Nature, 1981), establishing this locus as a protooncogene, initial cloning of human c-src gene and demonstrating oncogenecity of v-src DNA (PNAS, 1983), and the discoveries of several tyrosine kinase- and viral oncogenes (Nature Cell Biol, 2002, PNAS, 1992, 1998). In the area of prostate cancer, his lab contributed to: the first tyrosine kinase profile (PNAS, 1996), the discovery of truncated AR in CWR22Rv1 (Cancer Res, 2002, 2009), the discovery of IL6 and erbB crosstalk (Nature, 1998), the demonstration of IL6-induced neuroendocrine differentiation (PNAS, 1998), the identification of the first Long-noncoding RNA coactivator of myc (PNAS, 2014) and of HIF-1a (Nat Comm, 2017), the definition of the origin of human retrovirus XMRV (dispelling its involvement in prostate cancer) (Science, 2012), the first demonstration of tumor specific killing of prostate cancer by arginine-deprivation (Cancer Res, 2009), the discovery of chromatin-autophagy (PNAS, 2014), histone demethylase KDM4A as E2F coactivator and tumor metabolism (Cell Reports, 2016), arginine deprivation leads to cGAS-STING activation (Theranostics, 2021) and arginine as an epigenetic regulator of mitochondria (Nature Communication, 2021)

PUBLICATIONS:

REPRESENTATIVE RECENT PUBLICATIONS

1. , Fu CW, Yeh HH, Hu TL, Kuo ZK, Lin YC, Jhang MR, Hwang CS, Hsu HC, Kung HJ, Wang LY.Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer. EBioMedicine Apr;90:104500. doi: 10.1016, 2023
2. Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion Nat Commun. Mar 21;13(1):1511. (2022)
3. Chen CL, Hsu SC, Chung TY, Chu CY, Wang HJ, Hsiao PW, Yeh SD, Ann DK, Yen Y, Kung HJ. Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. Nat Commun (2021) 12:2398
4. Chu CY, Lee YC, Hsieh CH, Yeh CT, Chao TY, Chen PH, Lin IH, Hsieh TH, Shih JW, Cheng CH, Chang CC, Lin PS, Huang YL, Chen TM, Yen Y, Ann DK, Kung HJ. Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivaiton therapy. (2021) Theranostics 11: 3624 
5. Tseng LL, Cheng HH, Yeh TS, Huang SC, Syu YY, Chuu CP, Yuh CH, Kung HJ, Wang WC. Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proc Natl Acad Sci U S A. (2020) 117:24859
6. Yang CP, Yang WS, Wong YH, Wang KH, Teng YC, Chang MH, Liao KH, Nian FS, Chao CC, Tsai JW, Hwang WL, Lin MW, Tzeng TY, Wang PN, Campbell M, Chen LK, Tsai TF, Chang PC, Kung HJ. Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell. 19(5):e13107. (2020)
7. Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 77(2):213-227.e5. (2020)
8. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. RORg is a targetable mastr regulator of cholesterol biosynthesis in a cancer subtype. Nature Commun. (2019) Oct 11;10(1):4621. doi: 10.1038/s41467-019-12529-3.PMID:31604910
9. Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK. Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.(Nature) Commun Biol. (2018) Oct 26;1:178. PMID:30393775
10. Shih JW*, Chiang WF, Wu ATH, Wu MH, Wang LY, Yu YL, Hung YW, Wang WC, Chu CY, Hung CL, Changou CA, Yen Y, Kung HJ*. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. Nature Commun. 8:15874. doi: 10.1038/ncomms15874. (2017)
11. Wang LY, Hung CL, Chen YR, Yang JC, Wang J, Campbell M, Izumiya Y, Chen HW, Wang WC, Ann DK, Kung HJ*.  KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Rep. 16(11):3016-27. (2016)
12. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW*.  ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nature Medicine. 22(5):488-96. (2016)
13. Changou CA, Chen YR, Xing L, Yen Y, Chuang FY, Cheng RH, Bold RJ, Ann DK, Kung HJ*. Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy. Proc Natl Acad Sci USA.  111(39):14147-52. (2014)
14. Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ*, Wang WC*. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism. Proc Natl Acad Sci USA.  111(1):279-84. (2014)