Speaker

AFFILIATION:

Yale University School of Medicine, Department of Pharmacology, New Haven, CT

POSITION TITLE:

The William H. Prusoff Professor of Pharmacology

EDUCATION/TRAINING:

1965 – 1968 B.Sc. in Chemistry and Physics, Magna Cum Laude
The Hebrew University, Jerusalem

1968 – 1969 M.Sc. in Chemistry, Magna Cum Laude
The Hebrew University, Jerusalem

1970 – 1974 Ph.D. Thesis on "Study of Chemical and Biological Systems by Circular Polarization of Fluorescence," Department of Chemical Physics, The Weizmann Institute of Science, Rehovot, Israel

HONORS:

1973 Michael Landau Prize 

1980 Sara Leedy Prize  

1982 Elected to EMBO

1983 Hestrin Prize

1984 Levinson Prize 

1995 The Ciba-Drew Award 

1995 Antoine Lacassagne Prize 

1999 The Distinguished Service Award, Miami Nature Biotechnology 

1999 Honorary Member, The Japanese Biochemical Society 

2000 Elected to Neurosciences Research Program, La Jolla, California 

2000 Elected to the National Academy of Sciences 

2000 The Taylor Prize 

2001 Elected to the American Academy of Arts and Sciences 

2002 Honorary Doctor of Philosophy, Honoris Causa, University of Haifa 

2004 Elected to the European Academy of Sciences 

2005 Elected to the National Academy of Medicine (Formerly Institute of Medicine) 

2006 Dan David Prize 

2006 Elected as a foreign member of the Russian Academy of Sciences 

2008 Elected as a foreign member of the Croatian Academy of Science 

2009 Medal of Danica Hrvatska Order, Republic of Croatia 

2010 Penzcoller Foundation–AACR International Award for Cancer 

2011 American Italian Cancer Foundation Award in Scientific Excellence 

2012 Hope Funds for Cancer Research Award 

2015 BBVA Foundation Frontiers of Knowledge Award, Madrid, Spain 

2016 A Fellow of the AACR Academy 

2017 Clifford Prize for Cancer Research, Adelaide, Australia

RESEARCH INTERESTS:

Our laboratory is exploring the mode of action of growth factor receptors and the intracellular signaling pathways that are activated in response to growth factor stimulation. Receptor tyrosine kinases and cytoplasmic protein tyrosine kinases play a critical role in the control of many cellular processes including: cell proliferation, differentiation, metabolism, as well as cell survival and cell migration. Various diseases are caused by dysfunctions in receptor tyrosine kinases or in critical components of signaling pathways that are activated by receptors tyrosine kinases. In addition, various developmental disorders are caused by loss of function mutations in receptor tyrosine kinases. We are using biochemical and genetic approaches as well as X-ray crystallography to determine the mechanism of activation of receptor tyrosine kinases, how they recruit target proteins, and the mode of action of downstream signaling proteins in normal cellular processes and in diseases caused by dysfunctional receptor tyrosine kinases.

PUBLICATIONS:

Publications are listed on Google Scholar

https://scholar.google.com/citations?hl=en&user=L7vygrQAAAAJ