Tai-Lung Cha


National Defense Medical Center, Tri-Service General Hospital




National Defense Medical Center, MD, 1983/8-1990/8


The University of Texas, MD Anderson Cancer Center, PhD, 2000/8-2005/8





1. The research paper won in the Science Award 2005/11/11
2. Excellent Military Doctor in 2006/11/24
3. Personal Performance Award for Excellent Research Papers 2006/11/24
4. The First Prize of the Men's Medical Association Paper Award 2006/3
5. The first place in the research paper of the International Society of Surgery 2006/1
6. In 2005-2009, the Taiwan Cancer Foundation "Awarded and Assisted Medical Personnel of Medical Institutions to Engage in Clinical Research" Awarded Physicians
7. The 2008 [Taiwan Urology Association Journal Paper Group No. 3]
8. The 1st place in the 2009 [Taiwan Urology Association Journal Paper Group]
9. The 16th Taiwan Urology Association in 2009 - MSD Research Paper Award - Basic Group
10. The Excellent Military Doctor of the Hospital in 2009
11. Served as a reviewer for the on-site paper presentation of the "36th National Military Medical Academic Symposium" in 2009
12. The 2010 Annual Doctor's Day and Military Medical Conference "The Fifth Place of Excellent Treatises"
13. The Excellent Medical Staff of the National Army in 2011
14. The Excellent Mentor of National Defense Medical College in 2012
15. The 13th National Innovation Award in 2016 (Study-Research Innovation-Biotechnology Pharmaceutical Group)
16. The  Doctors Association Xinglin Award in 2017
17. The Teacher Award of the Ministry of Education in 2021


Tai-Lung Cha was born in Taipei, Taiwan, R.O.C. on September 30, 1964. I entered the National Defense Medical Center in 1983 and received my Doctor of Medicine (M.D.) degree in 1990. Then I practiced as a surgical resident and finished my fellowship in Division of Urology of Tri-Service General Hospital from 1992 to 1998. In September of 1998 I became an attending staff in Division of Urology of Tri-Service General Hospital. I joined Dr. Mien-Chie Hung’s Lab as a graduate student in the University of Texas at Houston Graduate School of Biomedical Science and M.D. Anderson Cancer Center in 2001. In year 2005, I got my Ph.D degree by publishing a high impact paper in “Science’ and came back to serve as an attending urologist of Tri-Service General Hospital in Taiwan. I was promoted as Vice Superintendent, Tri-Service General Hospital in 2016. In addition to clinical practice, I also devote to translational research of “Cancer epigenetics, cancer metastasis and molecular targeted therapy by in vitro and in vivo models”. 


  1. Hou TY, Chen MR, Chou YC, Kan PC, Tsai YT, Cha TL. Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis. Front Immunol. 2017 Jul 10;8:790. 

  2. Xiang-Me Lai, Shu-Yu Liu, Yi-Ta Tsai, Guang-Huan Sun, Sun-Yran Chang, Shih-Ming Huang and Tai-Lung Cha. HAF mediates the evasive resistance of anti-angiogenesis TKI through disrupting HIF-1α and HIF-2α balance in renal cell carcinoma. Oncotarget, Advance Publications 2017. Oncotarget SCI: 5.168(44 / 217)


  4. Tsai CH, Tzeng SF, Chao TK, Tsai CY, Yang YC, Lee MT, Hwang JJ, Chou YC, Tsai MH, Cha TL, Hsiao PW. Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells. Cancer Res. 2016 Oct 1;76(19):5756-5767. SCI:9.122


  6. Chin-Yu Liu, Yu-Ching Chou, Jane C. -J. Chao, Chien-Yeh Hsu, Tai-Lung Cha, Chih-Wei Tsao. The Association between Dietary Patterns and Semen Quality in a General Asian Population of 7282 Males. PLOS ONE .July 28, 2015(IF:3.234, R/C: 8/55)

  7. Chin-Li Chen, Chin-Yu Liu , Tai-Lung Cha, Chien-Yeh Hsu, Yu-Ching Chou, Sheng-Tang Wu, En Meng, Guang-Huan Sun, Dah-Shyong Yu, Chih-Wei Tsao. Does radical cystectomy outperform other bladder preservative treatments in elderly patients with advanced bladder cancer? The Journal of medical association(IF: 0.845, R/C: 96/156)

  8. Yi-Ta Tsai, Mei-Jen Chuang, Shou-Hung Tang, Sheng-Tang Wu, Yu-Chi Chen, Guang-Huan Sun1, Pei-Wen Hsia, Shih-Ming Huang, Hwei-Jen Lee,Cheng-Ping Yu, Jar-Yi Ho, Hui-Kuan Lin, Ming-Rong Chen, Chung-Chih, Lin, Sun-Yran Chang, Victor C. Lin, Dah-Shyong Yu and Tai-Lung Cha. Novel Cancer Therapeutics with Allosteric Modulation of The Mitochondrial C-Raf/DAPK Complex by Raf Inhibitor Combination Therapy.  Cancer Research 2015 (IF=9.329, R/C=11/211)

  9. Tai-Lung Cha, Mei-Jen Chuang, Shou-Hung Tang, Sheng-Tang Wu, Kuang-Hui Sun,Tzu-Ting Chen, Guang-Huan Sun, Sun-Yran Chang, Cheng-Ping Yu, Jar-Yi Ho, Shu-Yu Liu,Shih-Ming Huang and Dah-Shyong Yu. Emodin Modulates Epigenetic Modifications and Suppresses Bladder Carcinoma Cell Gr .MOLECULAR CARCINOGENESIS 54:167–177 (2015) (IF=4.770, R/C=62/291)

  10. Chih-Wei Tsao, Chin-Yu Liu, Yu-Ching Chou, Tai-Lung Cha, Shih-Chang Chen, Chien-Yeh Hsu. Exploration of the Association between Obesity and Semen Quality in a 7630 Male Population. PLOS ONE. March 30, 2015 (IF=3.534, R/C=8/55)

  11. HSIN CHUNG LIN, HERNG SHENG LEE, TZONG SHI CHIUEH, YU CHIEH LIN, HSIN AN LIN, YU CHUN LIN, TAI LUNG CHA and EN MENG. Histopathological assessment of inflammation and expression of inflammatory markers in patients with ketamine-induced cystitis. MOLECULAR MEDICINE REPORTS 11: 2421-2428, 2015(IF=1.484, R/C=86/124)

  12. Chih-Wei Tsao , Ching-Yu Liu, Tai-Lung Cha , Sheng-Tang Wu , Guang-Huan Sun, Dah-Shyong Yu, Hong-I Chen, Sun-Yran Chang, Shih-Chang Chen , Chien-Yeh Hsu. Artificial neural network for predicting pathological stage of clinically localized prostate cancer in a Taiwanese population. Journal of medical association 77(2014)513-518.(IF=1.172,R/C=5/7)

  13. C.-W. Tsao, C.-Y. Liu, T.-L. Cha, S.-T. Wu, S.-C. Chen & C.-Y. Hsu. Exploration of the ssociation between chronic periodontal disease and erectile dysfunction from a population-based view point. Andrologia 2014, xx, 1–6(IF=1.172,R/C=5/7)

  14. Shou-Hung Tang, Hsu-Shan Huang, Hong-Ui Wu, Yi-Ta Tsai, Mei-Jen Chuang, Cheng-Ping Yu, Shih-Ming Huang, Guang-Huan Sun, Sun-Yran Chang, Pei-Wen Hsiao, Dah-Shyong Yu, and Tai-Lung Cha. Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in vitro and in vivo . Oncotarget, Advance Publications 2014(SCI:6.627),

  15. Chang-Shuo Huang, Shye-Jye Tang, Ling-Yen Chung,Cheng-Ping Yu, Jar-Yi Ho, Tai-Lung Cha,Chii-Cheng Hsieh, Hsiao-Hsien Wang, Guang-Huan Sun, and Kuang-Hui Sun Galectin-1 Upregulates CXCR4 to Promote Tumor Progression and Poor Outcome in Kidney Cancer. J AmSoc Nephrol 25: 1486–1495, 2014(SCI:9.466)

  16. Ming-Hsin Yang, Chih-Wei Tsao, Sheng-Tang Wu, Feng-Ping Chuang, En Meng, Shou-Hung Tang, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha. The effect of circumcision on young adult sexual function. Kaohsiung Journal of Medical Sciences (2014) 30, 305-309.(SCI:0.502)

  17. C.-L. Chen, S.-T. Wu, C.-C. Kao, T.-L. Cha, C.-Y. Lee, and S.-H. Tang. Short-Term Result of Renal Transplantation Using Extracorporeal Membrane OxygenationeSupported Brain-Dead Donors. Transplantation Proceedings, 46, 1061-1063 (2014)

  18. En Meng, Sheng-Tang Wu, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu,

Sheng-Yran Chang. A murderer of young bladders: Ketamine-associated cystitis .Urological Science 24 (2013) 113-116.

  1. Mei-Jen Chuang, Sheng-Tang Wu, Thou-Hung Tang, Xiang-Me Lai, Hsiao-Chu Lai, Kai-Hsiang Hsu, Kuang-Hui Sun, Guang-Huan Sun, Sun-Yran Chang, Dah-Shyong Yu, Pei-Wen Hsiao, Shih-Ming Huang, Tai-Lung Cha. The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation. PLOS ONE. September 2013, Volume 8, Issue 9.(SCI:3.534)

  2. Tai-Lung Cha, Mei-Jen Chuang, Shou-Hung Tang, Sheng-Tang Wu, Kuang-Hui Sun,Tzu-Ting Chen, Guang-Huan Sun, Sun-Yran Chang, Cheng-Ping Yu, Jar-Yi Ho, Shu-Yu Liu, Shih-Ming Huang, and Dah-Shyong Yu. Emodin Modulates Epigenetic Modifications and Suppresses Bladder Carcinoma Cell Growth. MOLECULAR CARCINOGENESIS.2013 (SCI:4.770)

  3. Jin-Li Chen ,Tai-Lung Cha, Sheng-Tang Wu, Shou-Hung Tang , Chih-Wei Tsao , En Meng MD, Renal infarction secondary to ketamine abuse.  American Journal of Emergency Medicine 31 (2013) 1153.e3–1153.e5

  4. Po-Wei Huang, Tai-Lung Cha, Huang-Ching Chang, Guang-Huan Sun, Dah-Shyong Yu and En Meng. Hidden problem in an elderly woman with repeated urinary tract infection: Giant megaureters resulting from a ‘yo-yo’ phenomenon. Surgical Practice (2013) 17, 110–114

  5. Chih-Wei Tsao , Ming-Hung Lin, Sheng-Tang Wu , En Meng, Shou-Hung Tang,

Hong-I Chen , Guang-Huan Sun , Dah-Shyong Yu, Sun-Yran Chang , Tai-Lung Cha. Combining prostrate-specific antigen and Gleason score increases the

diagnostic power of endorectal coil magnetic resonance imaging in prostate

cancer pathological stage. Journal of the Chinese Medical Association 76 (2013) 20-24

  1. Cheng-Hsi Liao, Sheng-Tang Wu, Chien-Chang Kao, Tai-Lung Cha, Dah-Shyoung Yu, Guang-Huan Sun, and Shou-Hung Tang. Symptomatic Lymphoceles Following Cadaveric Transplantation: Single Center Experience.Journal of Medical Science. Volume 33, number 3 June 2013

  2. Ren-Jun Hsu, Jar-Yi Ho, Tai-Lung Cha, Dah-Shyong Yu, Chieh-Lin Wu, Wei-Ping Huang, Pauling Chu, Ying-Hsin Chen, Jiann-Torng Chen, Cheng-Ping Yu.WNT10A Plays an Oncogenic Role in Renal Cell Carcinoma by Activating WNT/b-catenin Pathway. PLOS ONE.October 2012,Volume 7,Issue 10, e47649(SCI:3.534)

  3. Chien-Chang Kao, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu,

Hong-I Chen, Sun-Yran Chang, Cheng-Ping Ma, Sheng-Tang Wu. Cost-effective homemade specimen retrieval bag for use in laparoscopic surgery: Experience at a single center. Asian Journal of Surgery (2012) 35, 140-143

  1. Ming-Yi Ho, Shye-Jye Tang, Mei-Jen Chuang, Tai-Lung Cha, Jing-Yao Li, Guang-Huan Sun, and Kuang-Hui Sun.TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. Mol Cancer Res. 2012 Aug;10(8):1109-19.

  2. Chien-Chang Kao , Yen-Hwa Chang , Tony Wu , Guang-Huan Sun , Dah-Shyong Yu, Sun-Yran Chang , Tai-Lung Cha. Open, multi-center, phase IV study to assess the efficacy and tolerability of triptorelin in Taiwanese patients with advanced prostate cancer. Journal of the Chinese Medical Association (2012) 1-7

  3. Ming-Hsin Yang, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Cheng-Ping Ma, Tai-Lung Cha. CEA-producing urothelial cell carcinoma with metastasis presenting as a rectal adenocarcinoma. Kaohsiung Journal of Medical Sciences (2012) 28, 624-627

  4. E. Meng, J.S. Young, T.L. Cha, G.H. Sun, D.S. Yu, and A.F. Brading, Neuronal-Derived Nitric Oxide Modulates the Activity of Mouse Detrusor Smooth Muscle, Neurourology and Urodynamics 31:572–578 (2012)

  5. Shou-Hung Tang, Chien-Chang Kao, Seng-Tang Wu, En Meng, Tai-Lung Cha*, Inlay buccal mucosal graft for reoperative posterior Urethroplasty, Kaohsiung Journal of Medical Sciences (2012) 28, 220-224

  6. En Meng, Han-Yu Chang, Sun-Yran Chang, Guang-Huan Sun, Dah-Shyong Yu and Tai-Lung Cha , Involvement of Purinergic Neurotransmission in Ketamine Induced Bladder Dysfunction Vol. 186, 1134-1141, September 2011 THE JOURNAL OF UROLOGY

  7. F-P Chuang, M Lakin, S-T Wu, T-L Cha, G-H Sun and DK Montague, Experience with intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: dose considerations, International Journal of Impotence Research (2011) 23, 146–150

  8. C. T. Lin, T. L. Cha, S. T. Wu and F. P. Chuang, Acute fulminant colon cancer metastasis after renal transplantation, DIG (Madrid) Vol. 102. N. 7, pp. 447-448, 2010

  9. Chien-Chang Kao, Ching-Jiunn Wu, Guang-Huan Sun, Dah-Shyong Yu, Hong-I Chen, ,Sun-Yran Chang, Cheng-Ping Ma, and Tai-Lung Cha, CONGENITAL SEMINAL VESICLE CYST ASSOCIATED WITH IPSILATERAL RENAL AGENESIS MIMICKING BLADDER OUTLET OBSTRUCTION: A CASE REPORT AND REVIEW OF THE LITERATURE. Kaohsiung J Med Sci January 2010 • Vol 26, No30-33

  10. Shou-Hung Tang, Chien-Chang Kao, Seng-Tang Wu, Feng-Ping Chuang, Tai-Lung Cha,

Combining Free Buccal Mucosal Graft and Local Tissue From Urethral Diverticulectomy to Repair Complex Urethral Sticure: Report of a Case, Formos J Surg 2010, 43, No5, 243-247

  1. Po-Wei Huang1, Tai-Lung Cha1, Huang-Ching Chang1 and Shou-Hung Tang, Target lesions in the bladder from emphysematous Cystitis, (nephrology image,SCI:6.193) Kidney International (2010) 78, 325

  2. Huang-Ching Chang, Ta-Chin Lin, Chang-Min Lin, Feng-Ping Chuang, Guang-Haun Sun, Tai-Lung Cha, Seng-Tang Wu. Malignant Pelvic Paraganglioma with Bladder Invasion. J Med Sci 2010; 30(3): 093-095

  3. C.-M. Lin, T.-H. Tsai, T.-C. Lin, S.-H. Tang, S.-T. Wu, G.-H. Sun, T.-L. Cha, Holmium : Yttrium-Aluminum-Garnet Laser Endoureterotomy for Benign Ureteral Strictures : a Single-Centre Experience, Acta Chir Belg, 2009, 109, 746-750. SCI:0.474