Angela Kay Eggleston


Springer Nature America, New York, NY


Senior Editor and Biological Sciences Team Manager


1985 B.S. Microbiology, University of Notre Dame, South Bend, IN

1988 M.S. Molecular Genetics, University of Notre Dame, South Bend, IN,

Advisor: Dr Michael Fennewald

1993 Ph.D. Biochemistry/Molecular Biology, Northwestern University, Evanston, IL,

Advisor: Dr Stephen Kowalczykowski


Imperial Cancer Research Fund post-doctoral fellowship, 1995

Burroughs-Wellcome Hitchings-Elion post-doctoral fellowship, 1996-1999




New JH, Eggleston AK, Fennewald M. 1988. Binding of the Tn3 transposase to the inverted repeats of Tn3. J. Mol. Biol. 201:589-599.

Roman LJ, Eggleston AK, Kowalczykowski SC. 1992. Processivity of the DNA helicase activity of Escherichia coli recBCD enzyme. J. Biol. Chem. 267:4207-4214.


Eggleston AK, Kowalczykowski SC. 1993. Biochemical characterization of a mutant recBCD enzyme, the recB2109CD enzyme, which lacks Chi-specific, but not non-specific, nuclease activity. J. Mol. Biol. 231:605-620.

Eggleston AK, Kowalczykowski SC. 1993. The mutant recBCD enzyme, recB2109CD enzyme, has helicase activity but does not promote efficient joint molecule formation in vitro. J. Mol. Biol. 231:621-633.

Eggleston AK, O'Neill TE, Bradbury EM, Kowalczykowski SC. 1995. Unwinding of nucleosomal DNA by a DNA helicase. J. Biol. Chem. 270:2024-2031.

Eggleston AK, Rahim NA, Kowalczykowski SC. 1996. A helicase assay based on the displacement of fluorescent, nucleic acid-binding ligands. Nucl. Acids Res. 24:1179-1186.

Eggleston AK, Mitchell AH, West SC. 1997. In vitro reconstitution of the late steps of genetic recombination in E. coli. Cell 89:607-617.

Eggleston AK, West SC. 2000. Cleavage of Holliday junctions by the Escherichia coli RuvABC complex. J. Biol. Chem. 275:26467-26476.



Eggleston AK, Kowalczykowski SC. 1991. An overview of homologous pairing and DNA strand exchange proteins. Biochimie 73:163-176. 


Kowalczykowski SC, Eggleston AK. 1994. Homologous pairing and DNA strand-exchange proteins. Annu. Rev. Biochem. 63:991-1043.

Kowalczykowski SC, Dixon DA, Eggleston AK, Lauder SD, Rehrauer WM. 1994. Biochemistry of homologous recombination in Escherichia coli. Microbiol. Rev. 58:401-465.

Eggleston AK, West SC. 1996. Exchanging partners: recombination in E. coli. Trends Genet. 12:20-26.

Eggleston AK, West SC. 1997. Recombination initiation: easy as A, B, C, D... Chi? Curr. Biol. 7:R745-749.


Highlights, picture stories, etc


Eggleston A. 2000. Hush, hush: the origin of telomeric silence. Nat. Cell Biol. 2:E27.


Eggleston A. 2000. It's good to talk: cell-cell communication by gap junctions. Nat. Cell Biol. 2:E81.


Eggleston A. 2000. Convergence of DNA repair and cell-cycle checkpoint control. Nat. Cell Biol. 2:E95.

Eggleston A. 2000. Steppin' out: processive myosin V movement on actin filaments. Nat. Cell Biol. 2:E128.

Eggleston A. 2001. Rab6-KIFL in a pinch. Nat. Cell Biol. 3:E9.

Eggleston A. 2001. Wasting away. Nat. Cell Biol. 3:E48.


Eggleston AK. 2004. E3 ligase activity and suppression of breast cancer. Nat. Struct. Mol. Biol. 11:8.

Eggleston AK. 2004. Biological techniques: tailor-made riboswitches. Nature 431:409.


Eggleston AK. 2005. Unraveling chromatin organization. Nat. Struct. Mol. Biol. 12:6.


Eggleston AK. 2005. Threaded for degradation. Nat. Struct. Mol. Biol. 12:1029.


Eggleston AK. 2006. Helicase à go-go-go. Nat. Struct. Mol. Biol. 13:101.


Eggleston AK. 2006. Herpesvirus in the dock. Nat. Struct. Mol. Biol. 13:188.


Eggleston AK. 2007. All mixed up. Nat. Struct. Mol. Biol. 14:13.


Eggleston AK. 2009. RNA silencing. Nature 457:395.


Nath D, Dhand R, Eggleston AK. 2010. Building a cell. Nature 463:445.


Eggleston AK, Eccleston A, Marte B, Lupp C. 2012. Regulatory RNA. Nature 482:321.


Cesari F, Chou IH, Eggleston AK, Heemels MT, Marte B, Weiss U. 2013. Frontiers in biology. Nature 493:317.


Cesari F, Chou IH, Eggleston AK, Gray N, Nath D, Shadan S, Skipper M. 2014. Frontiers in biology. Nature 505:301.



Research highlights/advances for PSI/Nature Structural Biology Knowledgebase


Eggleston, AK, Hodges, M, Montoya M. 2009. A new look at pore formation. PSI-SGKB doi:10.1038/nsmb0609-615.


Eggleston, AK, Hodges, M, Montoya, M. 2009. Spiral binding. PSI-SGKB doi:10.1038/nsmb0609-615.


Eggleston, AK. 2010. Seeing the Invisible. SBKB doi:10.1038/nsmb1010-1168-2-psi.


Eggleston, AK. 2013. Cell-Cell Interaction: Modulating Self Recognition Affinity. SBKB doi:10.1038/sbkb.2012.129.


Eggleston, AK. 2013. Protein Interaction Networks: When the Sum is Greater than the Parts. SBKB doi:10.1038/sbkb.2012.133.


Eggleston, AK. 2013. Protein-Nucleic Acid Interaction: A Modified SAM to Study tRNA. SBKB doi:10.1038/sbkb.2012.149.


Eggleston, AK. 2014. Protein and Peptide Synthesis: Sensing Energy Balance. SBKB doi:10.1038/sbkb.2014.223.