SPEAKERS
Angela Kay Eggleston
AFFILIATION:
Springer Nature America, New York, NY
POSITION TITLE:
Senior Editor and Biological Sciences Team Manager
EDUCATION/TRAINING:
1985 B.S. Microbiology, University of Notre Dame, South Bend, IN
1988 M.S. Molecular Genetics, University of Notre Dame, South Bend, IN,
Advisor: Dr Michael Fennewald
1993 Ph.D. Biochemistry/Molecular Biology, Northwestern University, Evanston, IL,
Advisor: Dr Stephen Kowalczykowski
HONORS:
Imperial Cancer Research Fund post-doctoral fellowship, 1995
Burroughs-Wellcome Hitchings-Elion post-doctoral fellowship, 1996-1999
RESEARCH INTERESTS:
PUBLICATIONS:
New JH, Eggleston AK, Fennewald M. 1988. Binding of the Tn3 transposase to the inverted repeats of Tn3. J. Mol. Biol. 201:589-599.
Roman LJ, Eggleston AK, Kowalczykowski SC. 1992. Processivity of the DNA helicase activity of Escherichia coli recBCD enzyme. J. Biol. Chem. 267:4207-4214.
Eggleston AK, Kowalczykowski SC. 1993. Biochemical characterization of a mutant recBCD enzyme, the recB2109CD enzyme, which lacks Chi-specific, but not non-specific, nuclease activity. J. Mol. Biol. 231:605-620.
Eggleston AK, Kowalczykowski SC. 1993. The mutant recBCD enzyme, recB2109CD enzyme, has helicase activity but does not promote efficient joint molecule formation in vitro. J. Mol. Biol. 231:621-633.
Eggleston AK, O'Neill TE, Bradbury EM, Kowalczykowski SC. 1995. Unwinding of nucleosomal DNA by a DNA helicase. J. Biol. Chem. 270:2024-2031.
Eggleston AK, Rahim NA, Kowalczykowski SC. 1996. A helicase assay based on the displacement of fluorescent, nucleic acid-binding ligands. Nucl. Acids Res. 24:1179-1186.
Eggleston AK, Mitchell AH, West SC. 1997. In vitro reconstitution of the late steps of genetic recombination in E. coli. Cell 89:607-617.
Eggleston AK, West SC. 2000. Cleavage of Holliday junctions by the Escherichia coli RuvABC complex. J. Biol. Chem. 275:26467-26476.
Reviews
Eggleston AK, Kowalczykowski SC. 1991. An overview of homologous pairing and DNA strand exchange proteins. Biochimie 73:163-176.
Kowalczykowski SC, Eggleston AK. 1994. Homologous pairing and DNA strand-exchange proteins. Annu. Rev. Biochem. 63:991-1043.
Kowalczykowski SC, Dixon DA, Eggleston AK, Lauder SD, Rehrauer WM. 1994. Biochemistry of homologous recombination in Escherichia coli. Microbiol. Rev. 58:401-465.
Eggleston AK, West SC. 1996. Exchanging partners: recombination in E. coli. Trends Genet. 12:20-26.
Eggleston AK, West SC. 1997. Recombination initiation: easy as A, B, C, D... Chi? Curr. Biol. 7:R745-749.
Highlights, picture stories, etc
Eggleston A. 2000. Hush, hush: the origin of telomeric silence. Nat. Cell Biol. 2:E27.
Eggleston A. 2000. It's good to talk: cell-cell communication by gap junctions. Nat. Cell Biol. 2:E81.
Eggleston A. 2000. Convergence of DNA repair and cell-cycle checkpoint control. Nat. Cell Biol. 2:E95.
Eggleston A. 2000. Steppin' out: processive myosin V movement on actin filaments. Nat. Cell Biol. 2:E128.
Eggleston A. 2001. Rab6-KIFL in a pinch. Nat. Cell Biol. 3:E9.
Eggleston A. 2001. Wasting away. Nat. Cell Biol. 3:E48.
Eggleston AK. 2004. E3 ligase activity and suppression of breast cancer. Nat. Struct. Mol. Biol. 11:8.
Eggleston AK. 2004. Biological techniques: tailor-made riboswitches. Nature 431:409.
Eggleston AK. 2005. Unraveling chromatin organization. Nat. Struct. Mol. Biol. 12:6.
Eggleston AK. 2005. Threaded for degradation. Nat. Struct. Mol. Biol. 12:1029.
Eggleston AK. 2006. Helicase à go-go-go. Nat. Struct. Mol. Biol. 13:101.
Eggleston AK. 2006. Herpesvirus in the dock. Nat. Struct. Mol. Biol. 13:188.
Eggleston AK. 2007. All mixed up. Nat. Struct. Mol. Biol. 14:13.
Eggleston AK. 2009. RNA silencing. Nature 457:395.
Nath D, Dhand R, Eggleston AK. 2010. Building a cell. Nature 463:445.
Eggleston AK, Eccleston A, Marte B, Lupp C. 2012. Regulatory RNA. Nature 482:321.
Cesari F, Chou IH, Eggleston AK, Heemels MT, Marte B, Weiss U. 2013. Frontiers in biology. Nature 493:317.
Cesari F, Chou IH, Eggleston AK, Gray N, Nath D, Shadan S, Skipper M. 2014. Frontiers in biology. Nature 505:301.
Research highlights/advances for PSI/Nature Structural Biology Knowledgebase
Eggleston, AK, Hodges, M, Montoya M. 2009. A new look at pore formation. PSI-SGKB doi:10.1038/nsmb0609-615.
Eggleston, AK, Hodges, M, Montoya, M. 2009. Spiral binding. PSI-SGKB doi:10.1038/nsmb0609-615.
Eggleston, AK. 2010. Seeing the Invisible. SBKB doi:10.1038/nsmb1010-1168-2-psi.
Eggleston, AK. 2013. Cell-Cell Interaction: Modulating Self Recognition Affinity. SBKB doi:10.1038/sbkb.2012.129.
Eggleston, AK. 2013. Protein Interaction Networks: When the Sum is Greater than the Parts. SBKB doi:10.1038/sbkb.2012.133.
Eggleston, AK. 2013. Protein-Nucleic Acid Interaction: A Modified SAM to Study tRNA. SBKB doi:10.1038/sbkb.2012.149.
Eggleston, AK. 2014. Protein and Peptide Synthesis: Sensing Energy Balance. SBKB doi:10.1038/sbkb.2014.223.