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SPEAKERS

Li-Jung Juan

AFFILIATION:

Genomics Research Center, Academia Sinica, Taiwan ROC

POSITION TITLE:

Professor and Research Fellow

EDUCATION/TRAINING:

China Medical University, Taiwan,         BS,   09/87-07/90, Medical Technology

The Pennsylvania State University, US PhD, 02/92-08/96, Genetics

HONORS:

  • 1st Prize, Departmental Research Poster Award (1/76), The Penn State University, 1995
  • 1st NHRI Postdoctoral Fellowship Award (3/40), 1998
  • Asia-Pacific International Molecular Biology Network (A-IMBN) Feature Report, 2008 and 2010
  • Genomics Research Center Major Discovery , 2008, 2010, 2012, 2014, 2019
  • Academia Sinica Major Discovery, 2008, 2010, 2019
  • Academia Sinica Career Development Award, 2009
  • 4th TienTe Lee Biomedical Foundation Young Scientist Research Award, 2009
  • Best 5 Article of Cell Reports 2012
  • Academia Sinica Investigator Award, 2017 and 2021
  • 18th YZ Hsu Science and Technology Paper Award, 2020
  • MOST Outstanding Research Award, 2021

RESEARCH INTERESTS:

Juan laboratory is interested in transcriptional and epigenetic regulation in development and disease. We used to study important epigenetic regulators which control viral replication and tumor malignancy. In recent years, we have been focusing on protein N-a-acetylation. We found that the protein N-a-acetyltransferase Naa10p is important for global DNA methylation, genomic imprinting, embryonic development and its overexpression can cause cancer and obesity.

PUBLICATIONS:

  1. Lee CC*, Shih YC, Kang ML, Chang YC, Chuang LM, Devaraj R and Juan LJ* (2019, Nov). Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-alpha-acetylation of Pgc1alpha. MOLECULAR CELL, 76(3), 500-515.e8. 

  2. Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y* and Juan LJ* (2017, Oct). The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. MOLECULAR CELL, 68(1), 89-103.

  3. Chu CS, Lo PW, Yeh YH, Hsu PH, Peng SH, Teng YC, Kang ML, Wong CH* and Juan LJ* (2014, Jan). O-GlcNAcylation regulates EZH2 protein stability and function. PNAS, 111(4), 1355-1360.

  4. Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ* (2013, Aug). Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis. CANCER RESEARCH, 73(15):4711-21.

  5. Hsu CH, Peng KL, Kang ML, Chen YR, Yang YC, Tsai CH, Chu CS, Jeng YM, Chen YT, Lin FM, Huang HD, Lu YY, Teng YC, Lin ST, Lin RK, Tang FM, Lee SB, Hsu HM, Yu JC*, Hsiao PW*, Juan LJ* (2012, Sep). TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Reports, 2, 568–579.

  6. Hsu CH, Peng KL, Jhang HC, Lin CH, Wu SY, Chiang CM, Lee SC, Yu WC, Juan LJ* (2012, May). The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription. Oncogene, 31, P. 2335-49.

  7. Chu CS, Hsu PH, Lo PW, Scheer E, Tora L, Tsai HJ, Tsai MD, Juan LJ* (2011, Oct). Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome. J Biol Chem, 286, P. 35843-51.

  8. Lee SB, Lee CF, Ou DS, Dulal K, Chang LH, Ma CH, Huang CF, Zhu H, Lin YS, Juan LJ* (2011, Aug). Host-viral effects of chromatin assembly factor 1 interaction with HCMV IE2. Cell Research, 21(8):1230-47. 

  9. Ou DS, Lee SB, Chu CS, Chang LH, Chung BC, Juan LJ* (2011, Apr). Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein. Cell Research, 4, p642-53.

  10. Lee CF, Ou DS, Lee SB, Chang LH, Lin RK, Li YS, Upadhyay AK, Cheng X, Wang YC, Hsu HS, Hsiao M, Wu CW*, Juan LJ* (2010, Aug). hNaa10p/Human arrest-defective 1 contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing. Journal of Clinical Investigation, 120, P. 2920-2930. 

  11. Lin RK, Wu CY, Chang JW, Juan LJ, Hsu HS, Chen CY, Lu YY, Tang YA, Yang YC, Yang PC, Wang YC* (2010, Jul). Dysregulation of p53/Sp1 control leads to DNA methyltransferase 1 overexpression in lung cancer. Cancer Research, 70, P.5807-5817. 

  12. Lee SB, Ou DS, Lee CF, Juan LJ* (2009, May). Gene-specific transcriptional activation mediated by the p150 subunit of the chromatin assembly factor 1. J. Biol. Chem, 284(21), P.14040-P14049. 

  13. Tu S, Teng YC, Yuan C, Wu YT, Chan MY, Cheng AN, Lin PH, Juan LJ*, Tsai MD* (2008, Apr). The ARID domain of H3K4 demethylase RBP2 binds to CCGCCC motif. Nat. Struct. Mol. Biol, 15(4):419-21. 

  14. Chiou SH, Yang YP, Lin JC, Hsu CH, Jhang HC, Yang YT, Lee CH, Ho LL, Hsu WM, Ku HH, Chen SJ, Chen SS, Chang MD, Wu CW*, Juan LJ* (2006, Nov). The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression. The Journal of Immunology, 177, 6199-6206.

  15. Chen WY, Juan LJ, Chung BC* (2005, Dec). SF-1 (Nuclear Receptor 5A1) activity is activated by cAMP via p300-mediated recruitment to active foci, acetylation and increased DNA-binding. Molecular and Cellular Biology, 25, P.10442-P.10453. 

  16. Hsu CH, Chang MD, Tai KY, Yang YT, Wang PS, Chen CJ, Wang YH, Lee SC, Wu CW, Juan LJ* (2004, Jun). HCMV IE2-mediated inhibition of HAT activity downregulates p53 function. EMBO Journal, 23, 2269-2280. Mu JJ, Tsay YG, Juan LJ, Fu TF, Huang WH, Chen DS, Chen PJ* (2004, Feb). The small delta antigen of hepatitis delta virus is an acetylated protein and acetylation of lysine 72 may influence its cellular localization and viral RNA synthesis. Virology, 319, 60-70. 

  17. Chiou SH, Liu JH, Hsu WM, Chen SS, Chang SY, Juan LJ, Lin JC, Yang YT, Wong WW, Liu CY, Lin YS, Liu WT, Wu CW* (2001, Oct). Upregulation of Fas ligand expression by human cytomegalovirus immediate-early gene 2: A novel mechanism in CMV-induced apoptosis in human retina. The Journal of Immunology, 167, 4098-4103. 

  18. Juan LJ, Shia WJ, Chen MH, Yang WM, Seto E, Lin YS and Wu CW* (2000, Jun). Histone deacetylases specifically downregulate p53-dependent gene activation. Journal of Biological Chemistry, 275, 20436-20443. 

  19. Juan LJ, Utley RT, Vignali M, Bohm L and Workman JL* (1997, Feb). H1-mediated repression of transcription factor binding to a stably positioned nucleosome. Journal of Biological Chemistry, 272, 3635-3640. 

  20. Utley RT, Owen-Hughes TA, Juan LJ, Cote J, Adams CC and Workman JL* (1996). In vitro analysis of transcription factor binding to nucleosomes and nucleosome disruption/displacement. Methods in Enzymology, 274, 276-91. 

  21. Juan LJ, Utley RT, Adams CC and Workman JL* (1994, Dec). Differential repression of transcription factor binding by histone H1 is regulated by the core histone amino termini. The EMBO Journal, 13, 6031-6040. 

  22. Vettese-Dadey M, Walter PP, Chen H, Juan LJ and Workman JL* (1994, Feb). Role of the histone amino termini in facilitated binding of a transcription factor, GAL4-AH, to nucleosome cores. Molecular and Cellular Biology, 14, 970-981. 

  23. Juan LJ, Walter PP, Taylor IC, Kingston RE and Workman JL* (1993). Nucleosome cores and histone H1 in the binding of GAL4 derivatives and reactivation of transcription from nucleosome templates in vitro. Cold Spring Harbor Symposia on Quantitative Biology, 58, 213-223.