Chin-Chi Kuo


China Medical University Hospital, Taichung, Taiwan


Vice Superintendent


Johns Hopkins University, School of Public Health, Baltimore, Maryland

Ph.D., 2012-2014, Department of Epidemiology, M.P.H., 2011


China Medical University, Taichung, Taiwan, M.D., 1996-2003



  • The Dyar Award, Department of Epidemiology, Johns Hopkins University, 2012-2013

  • Taiwan Government Scholarship, 2011-2013

  • Best Oral Presentation Paper, Annual Meeting of Taiwan Society of Nephrology 2009 (December 2009)

  • Young Investigator Award, 7th Asian Pacific Congress of Hypertension (APCH) 2009 (February 2009)

  • Best Teaching Resident Award, Department of Internal Medicine, National Taiwan University Hospital (2008)

  • Best Chief Resident Award, Department of Internal Medicine, National Taiwan University Hospital (2008)

  • Best Resident Award, Department of Internal Medicine, National Taiwan University Hospital (2006)

  • Sigma Xi Membership (Dec 2021~)

  • Young Physician Excellence Award, Taichung City Medical Association (2021) 

  • Big Data and Renal Medicine, Invited Demonstration, ASN TV, the American Society of Nephrology (2018)

  • Best Innovative Application Award, Ministry of Health and Welfare of Taiwan (2017) 

  • Phi Beta Kappa Membership (2015~) 



  • Data governance and integrated machine learning for medical practice

  • Environmental risk factors and chronic diseases, particularly the link between environmental metal exposure and the kidney dysfunction.

  • Epidemiology and control/prevention of chronic kidney disease, diabetes, and cardiovascular disease. I am also very interested in the cost-analysis in end stage renal disease to inform future policy modification of public renal health.


  • Wu CF, Liou HH, Kuo CC, et al. The Association of Urinary Sclerostin and Renal Magnesium Handling in Type 2 Diabetic Patients with Chronic Kidney Disease. Kidney Blood Press Res. 2021;46(4):514-522.

  • Tsai TL, Wang SL, Hsieh CJ, Wen HJ, Kuo, CC, Liu HJ, Sun CW, Chen ML, Wu MT. Association Between Prenatal Exposure to Metals and Atopic Dermatitis Among Children Aged 4 Years in Taiwan. JAMA Netw Open. 2021;4(10):e2131327.

  • Tsai TL, Lei WT, Kuo CC, Sun HL, Su PH, Wang SL. Maternal and childhood exposure to inorganic arsenic and airway allergy - A 15-Year birth cohort follow-up study. Environ Int. 2021;146:106243.

  • Tsai TL, Kuo CC, Hsu LI, Tsai SF, Chiou HY, Chen CJ, Hsu KH, Wang SL. Association between arsenic exposure, DNA damage, and urological cancers incidence: A long-term follow-up study of residents in an arseniasis endemic area of northeastern Taiwan. Chemosphere. 2021;266:129094.

  • Tsai ST, Wang WC, Lin YT, Huang WS, Huang HY, Wang CJ, Lin EZ, Kung WL, Guo YC, Lin KH, Lu MK, Yen PS, Chen WL, Tseng YL, Kuo CC, Cho DY, Chen CC, Tsai CH. Use of a Smartphone Application to Speed Up Interhospital Transfer of Acute Ischemic Stroke Patients for Thrombectomy. Front Neurol. 2021;12:606673.

  • Tsai ST, Lin FY, Chen PS, Chiang HY, Kuo CC. Three-year mortality in cryptococcal meningitis: Hyperglycemia predict unfavorable outcome. PLoS One. 2021;16(5):e0251749.

  • Lin YT, Liu YH, Hsiao YL, Chiang, HY, Chen PS, Chang  SN, Tsai HC, Chen CH, Kuo CC. Pharmacological blood pressure control and outcomes in patients with hypertensive crisis discharged from the emergency department. PLoS One. 2021;16(8):e0251311.

  • Lin RT, Lin YT, Hsia YF, Kuo CC. Long working hours and burnout in health care workers: Non-linear dose-response relationship and the effect mediated by sleeping hours-A cross-sectional study. J Occup Health. 2021;63(1):e12228.

  • Liang CC, Yeh HC, Lo YC, Chou CY, Yen TH, Tsai HC, Hsu SP, Kuo CC. Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism. J Endocrinol Invest. 2021;44(4):755-763.

  • Lai HC, Chang SN, Lin HC, Hsu YL, Wei HM, Kuo CC, Hwang KP, Chiang HY. Association between urine pH and common uropathogens in children with urinary tract infections. J Microbiol Immunol Infect. 2021;54(2):290-298.

  • King EK, Hsieh MH, Chang DR, Lu CT, Ting IW, Wang CCN, Chen PS, Yeh HC, Chiang HY, Kuo CC. Prediction of non-responsiveness to pre-dialysis care program in patients with chronic kidney disease: a retrospective cohort analysis. Sci Rep. 2021;11(1):13938.

  • Chiu YC, Lin YT, Hsia YF, Jung CR, Lo YC, Chen TM, Chan JC, Wang YC, Kuo CC, Hwang BF. Long-term exposure to fine particulate matter and osteoporotic fracture: A case-control study in Taiwan. Environ Res. 2021;196:110888. (Co-correspondence)

  • Chiang HY, Lin KR, Hsiao YL, Huang HC, Chang SN, Hung CH, Chang Y, Wang YC, Kuo CC. Association Between Preoperative Blood Glucose Level and Hospital Length of Stay for Patients Undergoing Appendectomy or Laparoscopic Cholecystectomy. Diabetes Care. 2021;44(1):107-115.

  • Chiang HY, Chen TC, Lin CC, Ho LC, Kuo CC, Chi CY. Trend and Predictors of Short-term Mortality of Adult Bacteremia at Emergency Departments: A 14-Year Cohort Study of 14 625 Patients. Open Forum Infect Dis. 2021;8(11):ofab485.

  • Chen PC, Lin FY, Huang HC, Chiang HY, Chang SN, Chen PS, Guo YC, Liao PS, Wei YC, Kuo CC. Diameter Reduction Determined Through Carotid Ultrasound Associated With Cardiovascular and All-Cause Mortality: A Single-Center Experience of 38 201 Consecutive Patients in Taiwan. J Am Heart Assoc. 2021:e023689.

  • Chang DR, Yeh HC, Ting IW, Lin CY, Huang HC, Chiang HY, Chang SN, Tsai HC, Lo YC, Hsiao CT, Chu PL, Kuo CC. The ratio and difference of urine protein-to-creatinine ratio and albumin-to-creatinine ratio facilitate risk prediction of all-cause mortality. Sci Rep. 2021;11(1):7851.

  • Yeh HC, Lo YC, Ting IW, Chu PL, Chang SN, Chiang HY, Kuo CC. 24-hour Serum Creatinine Variation Associates with Short- and Long-Term All-Cause Mortality: A Real-World Insight into Early Detection of Acute Kidney Injury. Sci Rep. 2020;10(1):6552.

  • Wu PH, Yu A, Tsai CW, Koh JL, Kuo CC, Chen ALP. Keyword extraction and structuralization of medical reports. Health Inf Sci Syst. 2020;8(1):18.

  • Ting IW, Yeh HC, Huang HC, Chiang HY, Chu PL, Kuo CC. Joint Longitudinal Low Calcium High Phosphorus Trajectory Associates with Accelerated Progression, Acute Coronary Syndrome and Mortality in Chronic Kidney Disease. Sci Rep. 2020;10(1):9682.

  • Lin YT, Lo YC, Chiang HY, Kuo CC. Particulate Air Pollution and Progression to Kidney Failure With Replacement Therapy: An Advanced CKD Registry-Based Cohort Study in Taiwan. Am J Kidney Dis. 2020;76(5):645-657 e641.

  • Liang HY, Lo YC, Chiang HY, Chen MF, Kuo CC. Validation and Comparison of the 2003 and 2016 Diastolic Functional Assessments for Cardiovascular Mortality in a Large Single-Center Cohort. J Am Soc Echocardiogr. 2020;33(4):469-480.

  • Chen AY, Chen B, Kuo CC. Better continuity of care improves the quality of end-of-life care among elderly patients with end-stage renal disease. Sci Rep. 2020;10(1):19716.

  • Chang YL, Wang JS, Yeh HC, Ting IW, Huang HC, Chiang HY, Hsiao CT, Chu PL, Kuo CC. Dialysis timing may be deferred toward very late initiation: An observational study. PLoS One. 2020;15(5):e0233124.

  • Yeh HC, Ting IW, Huang HC, Chiang HY, Kuo CC. Acute Kidney Injury in the Outpatient Setting Associates with Risk of End-Stage Renal Disease and Death in Patients with CKD. Sci Rep. 2019;9(1):17658.

  • Yeh HC, Lin YT, Ting IW, Huang HC, Chiang HY, Chung CW, Chang SN, Kuo CC. Variability of red blood cell size predicts all-cause mortality, but not progression to dialysis, in patients with chronic kidney disease: A 13-year pre-ESRD registry-based cohort. Clin Chim Acta. 2019;497:163-171.

  • Tsai TL, Kuo CC, Pan WH, Wu TN, Lin P, Wang SL. Type 2 diabetes occurrence and mercury exposure - From the National Nutrition and Health Survey in Taiwan. Environ Int. 2019;126:260-267.

  • Tsai CW, Huang HC, Chiang HY, Chung CW, Chiu HT, Liang CC, Yu T, Kuo CC. First-year estimated glomerular filtration rate variability after pre-end-stage renal disease program enrollment and adverse outcomes of chronic kidney disease. Nephrol Dial Transplant. 2019;34(12):2066-2078.

  • Tsai CW, Huang HC, Chiang HY, Chung CW, Chang SN, Chu PL, Kuo CC. Longitudinal lipid trends and adverse outcomes in patients with CKD: a 13-year observational cohort study. J Lipid Res. 2019;60(3):648-660.

  • Kuo CC, Chang CM, Liu KT, et al. Automation of the kidney function prediction and classification through ultrasound-based kidney imaging using deep learning. NPJ Digit Med. 2019;2:29.

  • Hsieh CY, Wang SL, Fadrowski JJ, Navas-Acien A, Kuo CC. Urinary Concentration Correction Methods for Arsenic, Cadmium, and Mercury: a Systematic Review of Practice-Based Evidence. Curr Environ Health Rep. 2019;6(3):188-199.

  • Chiang HY, Huang HC, Chung CW, Yeh YC, Chen YC, Tien N, Lin HS, Ho MW, Kuo CC. Risk prediction for 30-day mortality among patients with Clostridium difficile infections: a retrospective cohort study. Antimicrob Resist Infect Control. 2019;8:175.

  • Chiang HY, Chung CW, Kuo CC, Lo YC, Chang WS, Chi CY. First-4-week erythrocyte sedimentation rate variability predicts erythrocyte sedimentation rate trajectories and clinical course among patients with pyogenic vertebral osteomyelitis. PLoS One. 2019;14(12):e0225969.

  • Tsai CW, Chiu HT, Huang HC, Ting IW, Yeh HC, Kuo CC. Uric acid predicts adverse outcomes in chronic kidney disease: a novel insight from trajectory analyses. Nephrol Dial Transplant. 2018;33(2):231-241.

  • Kuo CC, Su PH, Sun CW, Liu HJ, Chang CL, Wang SL. Early-life arsenic exposure promotes atherogenic lipid metabolism in adolescence: A 15-year birth cohort follow-up study in central Taiwan. Environ Int. 2018;118:97-105.

  • Chou HW, Chiu HT, Tsai CW, Ting IW, Yeh HC, Huang HC, Kuo CC. Comparative effectiveness of allopurinol, febuxostat and benzbromarone on renal function in chronic kidney disease patients with hyperuricemia: a 13-year inception cohort study. Nephrol Dial Transplant. 2018;33(9):1620-1627.

  • Chen B, Kuo CC, Huang N, Fan VY. Reducing costs at the end of life through provider incentives for hospice care: A retrospective cohort study. Palliat Med. 2018;32(8):1389-1400.

  • Yeh HC, Ting IW, Tsai CW, Wu JY, Kuo CC. Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. BMC Nephrol. 2017;18(1):229.

  • Tsai CW, Ting IW, Yeh HC, Kuo CC. Longitudinal change in estimated GFR among CKD patients: A 10-year follow-up study of an integrated kidney disease care program in Taiwan. PLoS One. 2017;12(4):e0173843.

  • Tsai CW, Lin SY, Kuo CC, Huang CC. Serum Uric Acid and Progression of Kidney Disease: A Longitudinal Analysis and Mini-Review. PLoS One. 2017;12(1):e0170393.

  • Grau-Perez M, Kuo CC, Gribble MO, et al. Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study. Environ Health Perspect. 2017;125(12):127004.

  • Chen B, Fan VY, Chou YJ, Kuo CC. Costs of care at the end of life among elderly patients with chronic kidney disease: patterns and predictors in a nationwide cohort study. BMC Nephrol. 2017;18(1):36.

  • Kuo CC, Moon KA, Wang SL et al. The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence. Environ Health Perspect 2017; 125: 087001.

  • Tsai TL, Kuo CC*, Pan WH et al. The decline in kidney function with chromium exposure is exacerbated with co-exposure to lead and cadmium. Kidney Int 2017; 92: 710-720.(*corresponder)

  • Spratlen MJ, Gamble MV, Grau-Perez M et al. Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: Evidence from the Strong Heart Study. Food Chem Toxicol 2017; 105: 387-397.

  • Grau-Perez M, Kuo CC, Spratlen M et al. The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. Diabetes Care 2017; 40: 46-53.

  • Chang CT, Wang GJ,