Liuqing Yang


The University of Texas, MD Anderson Cancer Center, Houston, TX


Associate Professor, Department of Molecular and Cellular Oncology


Degree-Granting Education
Xinjiang University, Urumqi, China, BS, 1998, Biology
Georgia State University, Atlanta, GA, PHD, 2006, Biological Science
Postgraduate Training
Postdoctoral fellow, University of California, San Diego, La Jolla, CA, Michael G. Rosenfeld, 10/2006-2/2013


2008 Era of Hope Postdoctoral Award, Department of Defense Breast Cancer Research Program, 2008-2012
Pathway to Independence Award, National Institute of Health, 2011-2017
Faculty Science and Technology Acquisition and Retention Program, University of Texas, 2013-2016
First-time Faculty Recruitment Award, CPRIT, 2013-2017
Wall of Science Award for Outstanding Scientific Research, Institutional Research Executive Committee, MD Anderson, 2014
Outstanding Publication Award, MD Anderson Cancer Center, 2015
The Sheskey Family Fellowship for Breast Cancer Research, The Sheskey Family Foundation, 2015
Breast Cancer Research Program Breakthrough Award, Department of Defense, 2016-2019
Wilson S. Stone Memorial Award, MD Anderson Cancer Center, 2016
Sabin Family Fellowship, MD Anderson Cancer Center, 2018
American Association of Cancer Research NextGen Stars, American Association of Cancer Research, 2019
President's Recognition of Faculty Excellence Award, MDACC, 2019
Wall of Science Award for Outstanding Scientific Research, Institutional Research Executive Committee, MD Anderson, 2019-2020
Faculty Scholar Award, The University of Texas MD Anderson Cancer Center, 2020-2023
Sanofi-Cell Research Outstanding Research Article Award, Sanofi-Cell Research, 2020-present
2021 STAT Wunderkind Award, Stat News, 2021-present



Peer-Reviewed Original Research Articles
1. Yang L, Yang J, Huang Y, Liu ZR. Phosphorylation of p68 RNA helicase regulates RNA binding by the C-terminal domain of the protein. Biochem Biophys Res Commun 314(2):622-30, 2/2004. PMID: 14733953.
2. Yang L, Liu ZR. Bacterially expressed recombinant p68 RNA helicase is phosphorylated on serine, threonine, and tyrosine residues. Protein Expr Purif 35(2):327-33, 6/2004. PMID: 15135410.
3. Yang L, Lin C, Liu ZR. Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation. Mol Cancer Res 3(6):355-63, 6/2005. PMID: 15972854.
4. Lin C, Yang L, Yang JJ, Huang Y, Liu ZR. ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome. Mol Cell Biol 25(17):7484-93, 9/2005. PMCID: PMC1190289.
5. Yang L, Lin C, Liu ZR. Signaling to the DEAD box--regulation of DEAD-box p68 RNA helicase by protein phosphorylations. Cell Signal 17(12):1495-504, 12/2005. PMID: 15927448.
6. Yang L, Lin C, Liu ZR. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell 127(1):139-55, 10/2006. PMID: 17018282.
Liuqing Yang
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7. Yang L, Lin C, Zhao S, Wang H, Liu ZR. Phosphorylation of p68 RNA helicase plays a role in platelet-derived growth factor-induced cell proliferation by up-regulating cyclin D1 and c-Myc expression. J Biol Chem 282(23):16811-9, 6/2007. e-Pub 4/2007. PMID: 17412694.
8. Yang L, Lin C, Sun SY, Zhao S, Liu ZR. A double tyrosine phosphorylation of P68 RNA helicase confers resistance to TRAIL-induced apoptosis. Oncogene 26(41):6082-92, 9/2007. e-Pub 3/2007. PMID: 17384675.
9. Lin C, Yang L, Tanasa B, Hutt K, Ju BG, Ohgi K, Zhang J, Rose DW, Fu XD, Glass CK, Rosenfeld MG. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139(6):1069-83, 2009. PMCID: PMC2812435.
10. Carter CL, Lin C, Liu CY, Yang L, Liu ZR. Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter. Oncogene 29(39):5427-36, 9/2010. e-Pub 8/2010. PMCID: PMC2948064.
11. Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147(4):773-88, 11/2011. PMCID: PMC3297197.
12. Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, Merkurjev D, Ohgi KA, Meng D, Zhang J, Evans CP, Rosenfeld MG. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 500(7464):598-602, 8/2013. e-Pub 8/2013. PMID: 23945587.
13. Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell 159(5):1110-25, 11/2014. e-Pub 11/2014. PMCID: PMC4266991.
14. Jin C, Yang L, Xie M, Lin C, Merkurjev D, Yang JC, Tanasa B, Oh S, Zhang J, Ohgi KA, Zhou H, Li W, Evans CP, Ding S, Rosenfeld MG. Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens. PNAS 111(25):9235-9240, 2014.
15. Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes Dev 29(2):157-70, 1/2015. e-Pub 12/2014. PMCID: PMC4298135.
16. Xing Z, Park PK, Lin C, Yang L. LncRNA BCAR4 wires up signaling transduction in breast cancer. RNA Biol 12(7):681-9, 2015. PMCID: PMC4615247.
17. Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nat Cell Biol 18(2):213-24, 2/2016. e-Pub 1/2016. PMCID: PMC4791069.
18. Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, Barton MC. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Mol Cell 64(5):967-981, 12/2016. PMCID: PMC5137794.
19. Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick GE, Han L, Lin C, Yang L. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol 19(2):106-119, 2/2017. e-Pub 1/2017. PMCID: PMC5336186.
20. Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nat Cell Biol 19(3):238-251, 3/2017. e-Pub 2/2017. PMCID: PMC5332298.
21. Gong J, Li Y, Liu CJ, Xiang Y, Li C, Ye Y, Zhang Z, Hawke DH, Park PK, Diao L, Putkey JA, Yang L, Guo AY, Lin C, Han L. A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell Rep 21(7):1968-1981, 11/2017. PMID: 29141226.
22. Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA
promotes breast cancer brain metastasis. J Clin Invest 127(12):4498-4515, 12/2017. e-Pub 11/2017. PMCID: PMC5707156.
23. Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, Zhou J, Zhou Y, Marks JR, Hawke DH, Hung MC, Yang L, Han L, Ying H, Lin C. Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res 78(16):4524-4532, 8/2018. e-Pub 7/2018. PMCID: PMC6126676.
24. Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Res. e-Pub 1/2019. PMID: 30631154.
25. Youqiong Ye, Qingsong Hu, Hu Chen, Ke Liang, Yuan Yuan, Yu Xiang, Hang Ruan, Zhao Zhang, Anren Song, Huiwen Zhang, Lingxiang Liu, Lixia Diao, Yanyan Lou, Bingying Zhou, Li Wang, Shengtao Zhou, Jianjun Gao, Eric Jonasch, Steven H. Lin, Yang Xia, Chunru Lin, Liuqing Yang, Gordon B. Mills, Han Liang & Leng Han. Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy. Nature Metabolism, 3/2019.
26. Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, Yang L, Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest 129(3):1129-1151, 3/2019. e-Pub 2/2019. PMCID: PMC6391108.
27. Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. e-Pub 6/2019. PMID: 31160797.
28. Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi MP, Huo L, Scott A, Wang Y, Ma L, Lee JH, Bhutani MS, Weston B, Vellano C, Yang L, Lin C, Kim Y, MacLeod AR, Wang L, Wang Z, Song S, Ajani JA. LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma. Mol Cancer 18(1):141, 10/2019. e-Pub 10/2019. PMID: 31601234.
29. Egranov SD, Hu Q, Lin C, Yang L. LncRNAs as tumor cell intrinsic factors that affect cancer immunotherapy. RNA Biol:1-3. e-Pub 5/2020. PMID: 32449433.
30. Hu Q, Egranov SD, Lin C, Yang L. Long noncoding RNA loss in immune suppression in cancer. Pharmacol Ther:107591. e-Pub 5/2020. PMID: 32473960.
31. Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol 22(11):1332-1345, 11/2020. e-Pub 10/2020. PMID: 33106653.
32. Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest 131(8), 4/2021. PMCID: PMC8262501.
33. Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Guéant JL, Muntau AC, Blau N, Sutton VR, Schiff M, Feillet F, Zhang S, Lin C, Yang L. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science 373(6555):662-673, 8/2021. PMID: 34353949.
34. Li Y, Zhang Y, Hu Q, Egranov SD, Xing Z, Zhang Z, Liang K, Ye Y, Pan Y, Chatterjee SS, Mistretta B, Nguyen TK, Hawke DH, Gunaratne PH, Hung MC, Han L, Yang L, Lin C. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med 13(1):137, 8/2021. e-Pub 8/2021. PMCID: PMC8403366.
35. Shin DJ, Chen MK, Yin J, McGrail DJ, Dai H, Wei R, Zhang J, Zheng WJ, Do KA, Yang L, Hung MC and Lin SY. Exploiting induced vulnerability to overcome PARPi resistance andclonal heterogeneity in BRCA mutant triple-negative inflammatory breast cancer. Am J Cancer Res 12(1). In Press.
36. Zhang Y, Li Y, Sun C, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ and Lin C. Hormonal Therapies Upregulate MANF and Overcome Female Susceptibility to Immune Checkpoint-Inhibitor (ICI)-Myocarditis. Science Translational Medicine. Submitted.