Programme

Wellesley College, Wellesley, MA          BA          06/1975  Molecular Biology

Harvard Medical School, Boston, MA    MD         06/1979  Medicine

University of Pennsylvania, Philadelphia, PA       06/1980  Intern, Internal Medicine

Johns Hopkins Hospital, Baltimore, MD               06/1982  Resident, Internal Med.

National Cancer Institute, Bethesda, MD             06/1985  Medical Staff Fellow

Giants of Cancer Care – Breast Cancer (2021), Member, American Academy of Arts and Sciences (2019),

American-Italian Cancer Foundation Prize for Scientific Excellence in Medicine (2018), ASCO Allen S. Lichter

Visionary Leadership Award (2018), Jill Rose Award (2017), Fellow of the AACR Academy (2017),

Distinguished Daughters of Pennsylvania (2016), Johns Hopkins Society of Scholars (2016), Thomson

Reuters/Clarviate Highly Cited Researchers (2014, 2015, 2018), Pennsylvania Breast Cancer Coalition

Potamkin Award (2012), Member, National Academy of Medicine (formerly the Institute of Medicine) (2011),

Member, Association of American Physicians (2010), ASCO Gianni Bonadonna Breast Cancer Award (2010),

Johns Hopkins University Distinguished Alumna Award (2009), 11th American Association for Cancer

Research-Women in Cancer Research Charlotte Friend Award (2008), 7th Rosalind E. Franklin Award for

Women in Science, National Cancer Institute (2008), Fellow of the American Society of Clinical Oncology

(2007), Avon Foundation Medical Advancement Award (2003), William L. McGuire Memorial Lecture (2001),

Wellesley College Alumnae Achievement Award (2000), Brinker International Award for Breast Cancer

Research (1999), Research Award, American Cancer Society Maryland Chapter (1998), Susan G. Komen

Foundation Award (1986), Merck Clinician Scientist Award (1989-90), American Cancer Society Clinical

Oncology Career Development Award (1988-91), American Society of Clinical Oncology Young Investigator

Award (1986-7), Sigma Xi (1975), Phi Beta Kappa (1974).

I am an experienced laboratory, translational, and clinical investigator who has worked to move insights in cancer biology from the bench to the clinic and the community, particularly in the field of breast cancer. Our work focused on determinants of hormone response and resistance in preclinical models of human breast cancer with a special emphasis on the role of epigenetic regulation as well as the potential role for epigenetically targeted therapies in breast cancer. This research has been supported by a variety of NIH (R01, U01), Department of Defense, and foundation grants (e.g. Breast Cancer Research Foundation since 1998) I have played a leadership role in early phase clinical trials of novel therapeutics as well as the conduct of large national and international clinical trials that have helped to establish standards of care for women with breast cancer. I am a past Chair of the ECOG Breast Committee for five years and Co-chair of the NCI Breast Care Steering Committee from 2010 – 2016. I have been a Thomson Reuters/Clarivate Highly Cited investigator and am an elected member of the National Academy of Medicine and the American Academy of Arts and Sciences in recognition of my contributions.

 

I served as leader of the Breast Cancer Program at Johns Hopkins for many years and was the founding director of the Hopkins Breast Cancer SPORE (NIH P50 CA88843). From 2009-2016 I was the Director of the University of Pittsburgh Cancer Institute, one of the nation’s NCI-designated Comprehensive Cancer Centers (PI of NIH P30 CA047904). I have also served as President of the American Society of Clinical Oncology in 2007-8 and President of the American Association for Cancer Research in 2016-7. I served as a member of the National Cancer Institute’s Subcommittee A Cancer Centers and am currently a member of the NCI Board of Scientific Counselors and Clinical Trials and Translational Research Advisory Committee. In addition, I have been a member and/or chair of the external advisory boards for 10 NCI-designated cancer centers as well as the scientific advisory boards for four national cancer charities.