Speaker

AFFILIATION:

Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan

POSITION TITLE:

Associate Research Fellow

EDUCATION/TRAINING:

2010-2014 Postdoctoral Fellow – Dept. of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School

*Project:Dynamic biodistribution of extracellular vesicles using multiplexed fluorescent and bioluminescent reporters.

*Supervisor:Drs. Xandra Breakefield and Bakhos Tannous

2010/05 Ph.D. – Cell and Developmental Biology, Dept. of Cellular and Physiological Sciences, University of British Columbia

*Dissertation:The Role of Pannexins, a Novel Gap Junction Family, in Glioma Oncogenicity and Neuronal Differentiation

*Supervisor:Dr. Christian Naus

2003/05 B.Sc. – Cell Biology and Genetics, Dept. of Zoology, University of British Columbia

HONORS:

2024 NSTC Outstanding Research Award (國科會傑出研究獎), National Science and Technology Council, Taiwan

2022-25 International Outstanding Young Scholars Research Grant (國際年輕傑出學者研究計畫), National Science and Technology Council, Taiwan

2022 Young Scholars' Creativity Award (年輕學者創新獎), Foundation for the Advancement of Outstanding Scholarship (傑出人才發展基金會), Taiwan

2021 Young Scientist Award (青年醫學科技獎), YungShin Tien Te Lee Biomedical Foundation (永信李天德醫學基金會), Taiwan

2020-24 Career Development Awards (前瞻計畫), Academia Sinica, Taiwa

2020-23 Excellent Young Scholar Research Grant (優秀年輕學者研究計畫), National Science and Technology Council, Taiwan

2017-19 Academia Sinica Salary Bonus for Outstanding Faculties and Scholars, Academia Sinica, Taiwan

2015-17 Ministry of Science and Technology Salary Bonus for Recruitment of Outstanding Faculties and Scholars, Ministry of Science and Technology, Taiwan

2015 Partners in Excellence (Teamwork), Massachusetts General Hospital, USA

2013 Excellence in Research, American Society for Gene and Cell Therapy, USA

2013 Travel Award, American Society for Gene and Cell Therapy, US

2013 Young Investigator Award, International Society for Extracellular Vesicles, USA

2011-14 Postdoctoral Fellowship, Canadian Institute of Health Research (CIHR), Canada

RESEARCH INTERESTS:

*Molecular Bioimaging

*Cell-Cell and Cell-ECM Communications (e.g. exosomes, gap junctions)

*Cancer Cell Biology

*Gene Therapy

PUBLICATIONS:

1. Magoling, B., Chen, Y., Wu, A.Y., Wong, W.W., Chou, S.T., Huang, H., Sung, Y., Hsieh, H., Huang, P., Lee, K., Huang, K., Chen, R., Chen, Y., Lai, C.P.* (2023). Membrane protein modification modulates big and small extracellular vesicle biodistribution and tumorigenic potential in breast cancers in vivo. Advanced Materials. 35(13): e2208966. (IF: 27.4)

2. Driedonks, T.*, Jiang, L.*, Carlson, B., Han, Z., Liu, G., Queen, S.E., Shirk, E.N., Gololobova, O., Liao, Z., Nyberg, L.H., Lima, G., Paniushkina L., Garcia-Contreras, M., Schonvisky, K., Castell N., Stover, M., Guerrero-Martin, S., Richardson, R., Smith, B., Machairaki, V., Lai, C.P., Izzi J.M., Hutchinson, E.K., Pate, K.A.M., Witwer, K.W. (2022). Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina. Journal of Extracellular Biology. 10(1): e59. *Co-first authors. (IF: N/A)

3. Verweij., F., Balaj, L., Boulanger, C., Carter, D., Compeer, E., D’Angelo, G., El Andaloussi, S, Goetz, J.G., Gross, J., Hyenne, V., Krämer-Albers, E., Lai, C.P., Loyer, X., Mark, A., Momma, S., Hoen, E., N., Pegtel, M., Peinado, H., Raposo, G., Rilla, K., Tahara, H., Théry, C., van Royen, M., Vandenbroucke, R., Wehman, A., Witer, K., Wu, Z., Wubbolts, R., Niel, G.V. (2021). The power of imaging to understand extracellular vesicles in vivo. Nature Methods. 18 (9): 1013-1026. (IF: 36.1)

4. Chien, J.C., Badr, C.E.*, Lai, C.P.* (2021). Multiplexed bioluminescence-mediated tracking of DNA double strand break repairs in vitro and in vivo. Nature Protocols. 16, 3933-3953. *Co-last authors. (IF: 13.1)

5. mona, M., Brizzi, M.F., Choo, A.B.H., Dominici, M., Davidson, S.M., Grillari, J., Hermann, D.M., Hill, A.F., Kleijn, D., Lai, R.C., Lai, C.P., Lim, R., Monguió-Tortajada, M., Muraca, M., Ochiya, T., Ortiz, L.A., Toh, W.S., Yi, Y.W., Witwer, K.W., Giebel, B., Lim, S.K. (2021). Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. Cytotherapy. 23 (5): 373-380. (IF: 3.7)

6. Wu, A.Y., Sung, Y., Chen, Y., Chou, S.T., Guo, V., Chien, J.C., Ko, J.J., Yang, A.L., Huang, H., Chuang, J., Wu, S., Ho, M., Ericsson, M., Lin, W., Cheung, C.H.Y., Juan, H., Ueda, K., Chen, Y., Lai, C.P.* (2020). Multiresolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism. Advanced Science. 7 (19): 2001467-83. (IF: 14.3)

7. Chien J.C., Tabet E., Pinkham, K., da Hora, C.C., Chang, J.C., Lin, S., Badr C.E.*, Lai, C.P.* (2020). A multiplexed bioluminescent reporter enables real-time tracking of DNA double strand break repair dynamics in vitro and in vivo. Nucleic Acids Research. 48 (17): e100-117. *Co-last authors. (IF: 16.6)

8. Wu, Y.T., Ueda, K.,Lai, C.P.* (2019). Review: Proteomic analysis of extracellular vesicles for cancer diagnostics. Proteomics. 19 (1-2): 1800162-12. (IF: 3.4)

9. Chuo S.T., Chien, J.C.,Lai, C.P.* (2018). Review: Imaging extracellular vesicles: current and emerging methods. Journal of Biomedical Science. 25 (1):91-100. (IF: 9.0)