SPEAKERS
Prof. Le Thi Nguyet Minh
AFFILIATION:
Assistant Professor and Graduate Program Director, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine)
Principal Investigator, Institute for Digital Medicine, NUS Medicine
POSITION TITLE:
Assistant Professor and Graduate Program Director
Principal Investigator
EDUCATION/TRAINING:
Jane Coffin Childs Postdoctoral Fellow, Boston Children’s Hospital, Harvard Medical School,Boston 2010-2015
Ph.D. in Computational and Systems Biology, Singapore - Massachusetts Institute of Technology (MIT) Alliance, NUS 2005-2010
B.Sc (honours) in Life Sciences, NUS, Singapore 2002-2005
HONORS:
2022 National University of Singapore Graduate Mentor of the Year Award
2021 Falling Walls Venture (top-25 science startup leader)
2021 National University of Singapore Alumni Team Award
2021 Singaporean who made an impact, featured in “Stories of Integration&rdquo
2020 EMBO Global Young Investigator finalist
2019 Singapore National Research Foundation Fellowship finalist
2013 American Journey Vietnamese Writer Award
2011-14 Jane Coffin Childs Memorial Fund Postdoctoral Fellowship
2011 Jackson Laboratory Experimental Models of Cancer Travel Award
2009-10L'Oréal-Singapore for Women in Science National Fellowship
2005-09 Singapore- MIT Alliance Graduate Fellowship
2008 American Society for Cell Biology Worthington Predoctoral Fellowship (top-five Cell biology student)
2008 Austrian Symposium on Small RNA Travel award
2005 The International Society on Thrombosis and Haemostasis Reach the World Grant
2005 National University of Singapore Alumni Bursary Award
2004 Best Poster Award at the 3rd International Conference on Structural Biology and Functional Genomics
2003 Best Poster Award at the 8th Biological Sciences Graduate Congress in Singapore
2004 Lee Foundation Study Grant, Singapore
RESEARCH INTERESTS:
*Delivery of nucleic acid drugs and other therapeutics using extracellular vesicles (EVs)
*Characterization of EV uptake and intracellular trafficking
PUBLICATIONS:
1.Migara K Jayasinghe, Yock S Lay, Dawn LX Tian, Chang Y Lee, Chang Gao, Brendon ZJ Yeo, Faith YX Hou, Rebecca C Prajogo, Dong V Hoang, Dai C Phung, Daniel G Tenen, Minh TN Le*, Extracellular Vesicle Surface Display Enhances the Therapeutic Efficacy and Safety Profile of Cancer Immunotherapy, Molecular Therapy (2024) In Press. IF 12.1.
2.Migara K Jayasinghe#, Chang Gao#, Gracemary Yap, Brendon ZJ Yeo, Luyen T Vu, Douglas JW Tay, Wen X Loh, Zhen Q Aw, Huixin Chen, Dai C Phung, Dong V Hoang, Rebecca C Prajogo, Lissa Hooi, Fang Q Lim, Marco Pirisinu, Chee K Mok, Kah W Lim, Sze J Tang, Kai S Tan, Edward KH Chow, Leilei Chen, Anh T Phan, Justin JH Chu, Minh TN Le*, Red blood cell-derived extracellular vesicles display endogenous anti-viral effects and enhance the efficacy of anti-viral oligonucleotide therapy, ACS Nano (2023), 17(21): 21639-21661. IF 15.8.
3.Thach T Pham#, Anh H Le#, Cong P Dang, Suet Y Chong, Vinh D Do, Boya Peng, Migara K Jayasinghe, Dong V Hoang, Roma A Louise, Hong B Ong, Yuin-Han Loh, Jiong-Wei Wang, Han W Hou, Minh TN Le*, Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis, Journal of Extracellular Vesicles (2023), 12(8): 12354. IF 15.5.
4.Boya Peng#, Yuqi Yang#, Zhiyuan Wu, Rachel Tan, Eric YM Yeo, Marco Pirisinu, Thach T Pham, Migara K Jayasinghe, Tin C Pham, Kun Liang, Ng Shyh-Chang*, Minh TN Le*, Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia, Molecular Therapy (2023), 31(5): 1418-1436. IF 12.1.
5.Boya Peng#, Trinh M Nguyen, Migara K Jayasinghe, Chang Gao, Thach T Pham, Luyen T Vu, Eric YM Yeo, Gracemary Yap, Lingzhi Wang, Boon C Goh, Wai L Tam, Dahai Luo, Minh TN Le*, Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy, Journal of Extracellular Vesicles (2022), 11(4): e12187. IF 15.5.
6.Migara K Jayasinghe#, Marco Pirisinu#, Yuqi Yang#, Boya Peng, Chang Y Lee, Melissa Tan, Thach T Pham, Luyen T Vu, Xuan TT Dang, Tin C Pham, Huan Chen, Anskar YH Leung, William C Cho, Jiahai Shi, Minh TN Le*, Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy, Theranostics (2022), 12(7): 3288-315. IF 12.4.
7.Daniel X Zhang#*, Xuan TT Dang#, Luyen T Vu, Claudine MH Lim, Eric YM Yeo, Brenda WS Lam, Sai M Leong, Noorjehan Omar, Thomas C Putti, Yu C Yeh, Victor Ma, Jia-Yuan Luo, William C Cho, Gang Chen, Victor KM Lee, Andrew Grimson*, Minh TN Le*, αvβ1 integrin is enriched in extracellular vesicles of metastatic breast cancer cells: A mechanism mediated by galectin-3, Journal of Extracellular Vesicles (2022), 11(8): e12234. IF 15.5.
8.Tin C Pham#, Migara K Jayasinghe#, Yuqi Yang#, Thach T Pham#, Likun Wei, Waqas M Usman, Huan Chen, Marco Pirisinu, Jinhua Gong, Seongkyeol Kim, Boya Peng, Weixi Wang, Charlene Chan, Victor Ma, Nhung TH Nguyen, Dennis Kappei, Hung X Nguyen, William C Cho, Jiahai Shi,* Minh TN Le*, Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery. Journal of Extracellular Vesicles (2021), 10(4): e12057. IF 15.5. want
9.Luyen T Vu#, Boya Peng#, Daniel X Zhang, Victor Ma, Camille A Mathey-Andrews, Chun K Lam, Theodoros Kiomourtzis, Jingmin Jin, Larry McReynolds, Linfeng Huang, Andrew Grimson, William C Cho, Judy Lieberman, Minh TN Le*, Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b, Journal of Extracellular Vesicles (2019), 8(1): 1599680. IF 15.5.
10.Waqas M Usman#, Tin C Pham, Yuk Y Kwok, Luyen T Vu, Victor Ma, Boya Peng, Yuen S Chan, Likun Wei, Siew M Chin, Ajijur Azad, Alex BL He, Anskar YH Leung, Mengsu Yang, Ng Shyh-Chang, William C Cho, Jiahai Shi, Minh TN Le*, Efficient RNA drug delivery using red blood cell extracellular vesicles, Nature Communications (2018), 9(1): 2359. IF 14.7.