Speaker

AFFILIATION:

Institute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University

POSITION TITLE:

Distinguished Professor and Associate Dean

EDUCATION/TRAINING:

Ph.D. in Biochemistry and Biophysics (Laboratory of Donald J. Graves, Iowa State University)

HONORS:

*The 14th National Innovation Award (2017)

*The 18th National Innovation Award (2021)

RESEARCH INTERESTS:

Drug repurposing for the treatment of cancer and disease, development of drug-biomarker pairs for precision medicine

PUBLICATIONS:

1.Engineered Extracellular Vesicles Carrying Let-7a-5p for Alleviating Inflammation in Acute Lung Injury. Journal of Biomedical Science 31:30 (2024)

2.Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis. Advanced Science 11:e2306373 (2024)

3.Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer. Nature Communications 14:6692 (2023)

4.Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways. Cell Communication and Signaling 21:184. (2023)

5.BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death. Cell Communication and Signaling 20(1):200. (2022)

6.Mesenchymal stem cell secreted-extracellular vesicles are involved in chondrocyte production and reduce adipogenesis during stem cell differentiation. Tissue Engineering and Regenerative Medicine 19:1295–1310 (2022)

7.Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) suppress SARS-CoV-2 entry and COVID-19 related cytokine storm in vitro. Frontiers in Pharmacology 12:765553 (2022)

8.Dehydroepiandrosterone (DHEA) Sensitizes Irinotecan to Suppress Head and Neck Cancer Stem-like Cells by Downregulation of WNT Signaling. Frontiers in Oncology 12:775541 (2022)

9.Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells. International Journal of Molecular Sciences 20(3):473 (2019)

10.Identification of Thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death and Disease 6:e1753 (2015).

11.Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. American Journal of Respiratory and Critical Care Medicine 186(11):1180-1188 (2012)