Speaker

AFFILIATION:

Vice President, R&D (Research and Clinical Development),
Shineon BioMedical, Co, Ltd. 2023-present
Professor, Department of Ophthalmology, China Medical University Hospital

POSITION TITLE:

Vice President, R&D (Research and Clinical Development)
/Professor

EDUCATION/TRAINING:

Institute of Biopharmaceutical Science, National Yang-Ming University PhD, 2008

School of Law, National Taipei University BL, 2004

School of Medicine, National Taiwan University MD, 1998

HONORS:

*Wu Ta-You Research Award, Ministry of Science and Technology, Taiwan 2015

*Best Clinical Research Award, Taipei Medical University 2015, 2014, 2012, 2011

*Best Young Investigator Award, Taipei Medical University, Best Research of Universit

*Best Paper Award, the Ophthalmologic Society of Taiwan 2011, 2010, 2008, 2005

*Taiwan Society for Stem Cell Research (TSSCR) Poster Award 2008

*Best Paper Award, Buddist Tsu Chi Hospital 2007

*The Association of Research in Vision and Ophthalmology (ARVO) International Travel Grant Award 2006

*Outstanding Physician Award, Veteran Affairs Commission, Taiwan 2004

*Best Teaching Chief Resident, Taipei Veteran General Hospital 2002

RESEARCH INTERESTS:

*Lead development of a series of novel, first-in-class anticancer therapeutics including

*Tri-specific antibody

*Targeted exosomal drug

*Supervise OPH related exosomal research

PUBLICATIONS:

1. Yang TK, Kuo HT, Ju YJ, Chen CY, Chen WH, Wu AY, Lin CJ, Lee CC*, Ho JH*. Comparative analysis of medical treatments for long-term control of normal tension glaucoma: a systematic review and model-based network meta-analysis. Clin & Exp Ophthalmol (In Press). (Corresponding Author)

2. Lin YC, Chen MC, Huang SW, Chen Y, Ho JH, Lin FY, Tan XT, Chiang HC, Huang CC, Tu CY, Cho DY, Chiu SC.Targeting Dual Immune Checkpoints PD-L1 and HLA-G by Trispecific T Cell Engager for Treating Heterogeneous Lung Cancer. Adv Sci (Weinh). 2024:e2309697.

3. Kuo HT, Yeh CY, Hsu AY, Ho JH, Lin CJ, Tsai YY. Clinical Efficacy of Omidenepag Isopropyl for Primary Open-Angle Glaucoma, Normal Tension Glaucoma, or Ocular Hypertension: A Meta-Analysis. J Ocul Pharmacol Ther. 2023;39(10):705-715.

4. Lin WT, Wu HH, Lee CW, Chen YF, Huang L, Hui-Chun Ho J,* Kuang-Sheng Lee O*. Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization.Mol Ther Nucleic Acids. 2023;35(1):102102. (Corresponding Author)

5. Chemaly RF, Marty FM, Wolfe CR, Lawrence SJ, Dadwal S, Soave R, Farthing J, Hawley S, Montanez P, Hwang J, Ho JH, Lewis S, Wang G, Boeckh M. DAS181 Treatment of Severe Lower Respiratory Tract Parainfluenza Virus Infection in Immunocompromised Patients: A Phase 2 Randomized, Placebo-Controlled Study. Clin Infect Dis 2021;73(3):e773-e781.

6. Danziger-Isakov Lara, Khalil N, Divanovic A, Frenck R, Grimley M, Iliopoulos I, Marsh R, Paulsen G, Phillips C, Schulert G, Spearman P, Blum S, Ho JH. Novel treatment of infant with COVID-19 with the sialidase fusion protein, DAS181. Pediatric Infect Dis 2021;40:e234-e235.

7. Wu JH, Liu TY A, Hsu WT, Ho JH, Lee CC. Performance and limitation of machine learning algorithms for diabetic retinopathy screening: A meta-analysis. J Med Internet Res 2021;23:e23863.

8. Chen YF, Li YJ, Chou CH, Chiew MY, Huang HD, Ho JH*, Chien S*, Lee OK*. Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458. Sci Adv 2020;6:eaay0264. (Corresponding Author)

9. Ho JH, Zhao Y, Liu Z, Zhou X, Chen X, Xianyu Y, Lewis S, Fan L, Tian Y, Chang N, Gong Z*, Ke Hu K*. Resolution of COVID-19 infection and pulmonary pathology with nebulized DAS181: A pilot study. Crit Care Explor 2020;2:e0263.

10. Hsiao CH, Ji AT, Chang CC, Chien MH, Lee LM, Ho JH*. Mesenchymal stem cells restore the sperm motility from testicular torsion-detorsion injury by regulation of glucose metabolism in sperm. Stem Cell Res & Ther 2019;10:270. (Corresponding Author)

11. Lin NC, Wu HH, Ho JH*, Liu CS*, Lee OK*. Mesenchymal stem cells prolong survival and prevent lethal complications in a porcine model of fulminant liver failure. Xenotransplantation. 2019;20:e12542. (Corresponding Author).

12. Chen WT, Hsu WT, Yen MH, Changou CA, Han CL, Chen YJ, Cheng JY, Chang TH, Lee OK, Ho JH*. Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization. Biomaterials. 2019;190-191:1-10. (Corresponding Author).

13. Tsai YA, Liu RS, Lirng JF, Yang BH, Chang CH, Wang Y, Wu YS, Ho JH, Lee OK, Soong BW. Treatment of Spinocerebellar Ataxia with Mesenchymal Stem Cells: A Phase I-IIa Clinical Study. Cell Transplant. 2017;26(3):503-512.

14. Lee CW, Huang WC, Huang HD, Huang YH, Ho JH, Yang MH, Yang VW, Lee OK. DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells. Stem Cell Reports. 2017;9(1):247-263.

15. Chang CC, Chang CW, Nguyen PA, Chang TH, Shih YL, Chang WY, Horng JT, Lee OK, Ho JH*. Ankylosing spondylitis and the risk of cancer. Oncol Lett. 2017;14(2):1315-1322.

16. Yang YH, Hsieh TL, Ji AT, Hsu WT, Liu CY, Lee OK, Ho JH.* Stromal tissue rigidity promotes mesenchymal stem cell-mediated corneal wound healing through the transforming growth factor β signaling pathway. Stem Cells 2016;34(10):2525-2535 (Corresponding Author).

17. Yen MH , Wu YY, Liu YS, Rimando M, Ho JH,* Lee OK*. Efficient Generation of Hepatic Cells from Mesenchymal Stromal 1 Cells by an Innovative Bio-Microfluidic Cell Culture Device. Stem Cell Res & Ther 2016;7(1):120. (Corresponding Author)

18. Hsieh CY, Liao YP, Wu CC, Yuan SP, Ho JH, Roan R, Liew PL, Lai MT, Lee F. Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report. Oncol Lett. 2016;12(2):1007-1010.

19. Shiau CC, Wu CL*, Ho JH.* Making Tentative Diagnosis of Glaucoma by Family Physicians. Taipei City Med J 2016 (Corresponding Author).

20. Lo YP, Liu YS, Rimando MG, Ho JH, Lin KH, Lee OK. * Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells. Scientific Reports 2016;6:21253.

21. Wu HH, Ho JH*, Lee OK*. Detection of Hepatic Maturation by Raman Spectroscopy in Mesenchymal Stromal Cells Undergoing Hepatic Differentiation. Stem Cell Res Ther 2016;7(1):6 (Corresponding Author)

22. Chang CC, Hsieh TL, Tiong TY, Hsiao CH, Ji AT, Hsu WT, Lee OK*, Ho JH*. Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR. Biomaterials 2015;60:141-50. (Corresponding Author).

23. Teng NY, Liu YS, Wu HH, Liu YA, Ho JH*, Lee OK*. Promotion of Mesenchymal-to-Epithelial Transition by Rac1 Inhibition with Small Molecules Accelerates Hepatic Differentiation of Mesenchymal Stromal Cells. Tissue Eng Part A. 2015;21(7-8):1444-54. (Corresponding Author)

24. Hsiao CH, Ji AT, Chang CC, Cheng CJ, Lee LM, Ho JH*. Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury. Stem Cell Res Ther 2015;6:113. (Corresponding Author)

25. Ji AT, Chang YC, Fu YJ, Lee OK*, Ho JH*. Niche-dependent regulations of metabolic balance in high-fat diet induced diabetic mice by mesenchymal stromal cells. Diabetes 2015;64(3):926-36. (Corresponding Author).

26. Kuo YC, Chang TH, Hsu WT, Zhou J, Lee HH, Ho JH* Chien S*, Lee OK*. Oscillatory Shear Stress Mediates Directional Re-organization of Actin Cytoskeleton and Alters Differentiation Propensity of Mesenchymal Stem Cells. Stem Cells 2015;33(2):429-42. (Corresponding Author).

27. Chang TH, Huang HD, Ong WK, Fu YJ, Lee OK, Chien S, Ho JH*. The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells. Biomaterials 2014;35(13):3934-44. (Corresponding Author).

28. Lien GS, Liu JF, Chien MH, Hsu WT, Chang TH, Ku CC, Ji AT, Tan P, Hsieh TL, Lee LM, Ho JH.* The ability to suppress macrophage-mediated inflammation in orbital fat stem cells is controlled by miR-671-5p. Stem Cell Res Ther 2014;5(4):97. (Corresponding Author)

29. Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM. In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. PLoS One. 2013;8(7):e69658.

30. Lin KJ, Loi MX, Lien GS, Cheng CF, Pao HY, Chang YC, Ji AT, Ho JH*. Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration. Stem Cell Res Ther 2013 14;4(3):72 (Corresponding Author)

31. Lin KJ, Loi MX, Lei SY, Shiau CC, Wu CL, Ho JH*. Decrease in Inner Retinal Thickness at Para- and Peri-Foveal Areas before Vascular Retinopathy in Patients with Metabolic Risk Factors. Taiwan J Ophthalmol 2013;3(3):108-115. (Corresponding Author)

32. Ho JH*, Lee OK, Fu YJ, Shih HT, Tseng CY, Chung CC, Han CL, Chen YJ. An iTRAQ Proteomic Study Reveals an Association between Diet-Induced Enhanced Fatty Acid Metabolism and the Development of Glucose Intolerance in Prediabetic Mice. J Proteome Res. 2013;12(3):1120-33. (Corresponding Author)

33. Ong WK, Chen HF, Tsai CT, Fu YJ, Wong YS, Yen DJ, Chang TH, Huang HD, Lee OK, Chien S, Ho JH.* The activation of directional stem cell motility by green light-emitting diode irradiation. Biomaterials 2013;34(8):1911-20. (Corresponding Author)

34. Ke CC, Liu RS, Yang AH, Liu CS, Chi CW, Tseng LM, Tsai YF, Ho JH, Lee CH, Lee OK. CD133-expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy. Eur J Nucl Med Mol Imaging. 2013;40(1):61-71.

35. Chien MH, Bien MY, Ku CC, Chang YC, Pao HY, Yang YL, Hsiao M, Chen CL, Ho JH.* Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury. Crit Care Med 2012;40(4):1245-53. (Corresponding Author)

36. Li CT, Lo KC, Chang HY, Wu HT, Ho JH, Yen TJ. Ag/Au bi-metallic film based color surface plasmon resonance biosensor with enhanced sensitivity, color contrast and great linearity. Biosens Bioelectron. 2012;36(1):192-8.

37. Chang YK, Liu YP, Ho JH, Hsu SC, Lee OK. Amine-surface-modified superparamagnetic iron oxide nanoparticles interfere with differentiation of human mesenchymal stem cells. J Orthop Res. 2012;30(9):1499-506.

38. Ho JH, Hong CY. Cardiovascular protection of magnolol: cell-type specificity and dose-related effects. J Biomed Sci 2012;19:70.

39. Kuo SW, Lin HI, Ho JH, Shih YV, Chen HF, Yen TJ, Lee OK. Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires. Biomaterials 2012;33(20):5013-22.

40. Cheng CF, Tsai CL, Lee OK, Feng JJ, Ho JH.* Anterior Chamber Paracentesis Facilitates Laser Peripheral Iridotomy And Restores Vision In Mild And Moderate Acute Primary Angle Closure Glaucoma. J Exp Clin Med 2012;4(1):52-57. (Corresponding Author)

41. Chang YK, Chen MH , Chiang YH, Chen YF, Ma WH, Tseng CY, Soong BW, Ho JH*, Lee OK *. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. J Biomed Sci 2011;18 (1): 54. (Corresponding author)

42. Hung SP, Ho JH, Shih YV, Lo T, Lee OK. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res 2012;30(2):260-6.

43. Kuo YC, Ho JH, Yen TJ, Chen HF, Lee OK. Development of a surface plasmon resonance biosensor for real-time detection of osteogenic differentiation in live mesenchymal stem cells. PLoS One 2011;6(7):e22382.

44. Ho JH, Hong CY. Salvianolic Acids: small compounds with multiple mechanisms for cardiovascular protection. J Biomed Sci 2011;18(1):30.

45. Ho JH, Tseng TC, Ma WH, Ong WK, Chen YF, Chen MH, Lin MW, Hong CY, Lee OK. Multiple intravenous transplantations of mesenchymal stem cells effectively restore long-term blood glucose homeostasis by hepatic engraftment and beta cell differentiation in streptozocin-induced diabetic mice. Cell Transplant 2012;21(5):997-1009.

46. Ho JH, Chen YF, Ma WH, Tseng TC, Chen MH, Lee OK. Cell Contact Accelerates Replicative Senescence of Human Mesenchymal Stem Cells Independent of Telomere Shortening: Roles of Ras and Oxidative Stress. Cell Transplantation 2011;20(8):1209-1210.

47. Lo T, Ho JH, Yang MH, Lee OK. Glucose reduction maintains stemness and prevents replicative senescence in human mesenchymal stem cells. Cell Transplantation 2011;20(6):813-25.

48. Ho JH*, Ma WH, Tseng TC, Chen YF, Chen MH, Lee OK. Isolation and Characterization of Multi-Potent Stem Cells from Human Orbital Fat Tissues. Tissue Eng Part A 2011;17(1-2):255-66. (Corresponding Author)

49. Ho JH, Su Y, Chen KH, Lee OK. Protection of Thymosin Beta-4 on Corneal Endothelial Cells from UVB-induced Apoptosis. Chinese J Physiol 2010;53(3):190-195.

50. Ho JH, Ma WH, Su Y, Tseng KC, Kuo TK, Lee OK. Thymosin Beta-4 Directs Cell Fate Determination of Human Mesenchymal Stem Cells through Biophysical Effects. J Orthop Res 2010;28(1):131-138

51. Kuo TK, Ho JH,* Lee OK. Mesenchymal Stem Cell Therapy for Non-musculoskeletal Diseases: Emerging Applications. Cell Transplant 2009;18(9):1013-1028. (Corresponding Author)

52. Ho JH, Tseng KC, Ma WH, Chen KH, Lee OK, Su Y. Thymosin beta-4 up-regulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage. Brit J Ophthalmol 2008;92(7):992-997.

53. Ho JH, Chuang CH, Ho CY, Shih YR, Lee OK, Su Y. Internalization is essential for the anti-apoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. Invest Ophth Vis Sci 2007;48(1):27-33.

54. Peng KL, Chen KH, Hsu WM, Ho HC, Chiang CC, Lee YC, Lai JY. Corneal injury by anti-misting agent in swim goggles: a case report. Cornea 2006;25(2):228-31.

55. Ho HC, Chen KH, Hsu WM, Lee SM, Chiang CC, Li YS. Linear-Long Incisions with a Small Optical Zone for the Correction of High Astigmatism. Ophthalmology 2004;111(1):28-33.

56. Kau HC, Ho HC, Kao SC, Yang CF, Hsu WM, Tsai CC. T-cell lumphoma in the eyelid following B-cell lymphoma. Eye 2002;16(6):794-796.

57. Tsai CC, Ho HC, Kau HC, Kao SC, Hsu WM. Optic neuritis: a rare manifestation of nasopharyngeal carcinoma. Eye 2002;16(4):501-503.

58. Joe CK, Ho HC. Comparison of the results of the glaucomatous field loss on frequency doubling perimetry and autoperimetry. Taiwan J Ophthalmol 2001;40(1):36-41.