Speaker

AFFILIATION:

Tranlational Medicine Research Center /Neurology, China Medical University Hospital
Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan

POSITION TITLE:

Vice superintendent/Professor

EDUCATION/TRAINING:

National Defense Medical Center 97/00 Medical Science Education

National Defense Medical Center 82/89 Medical Education

HONORS:

2023第二十屆國家新創獎－學研新創獎 - 開發三特異性抗體銜接免疫細胞藥物治療實體癌

2023第二十屆國家新創獎 精準醫學-基因修飾之間質幹細胞的外泌體治療腦中風，財團法人生技醫療科技政策研究中心

2022第十九屆國家新創獎：學研新創獎，生策會

2020第十七屆國家新創獎-學研新創獎，財團法人生技醫療科技政策研究中心

2020未來科技獎，科技部

2015第十二屆國家新創獎-學研新創獎，社團法人國家生技醫療產業策進會

2014趙百師老師論文獎，台灣腦中風學會

2008李悌愷教授優秀論文獎，台灣腦中風學會

RESEARCH INTERESTS:

*Stroke

*Stem cell biology

*Immunology

*Molecular Neurobiology

PUBLICATIONS:

1. Lin SL, Lee W, Liu SP, Lee HT, Jeng LB, Shyu WC*. Role of STAT3-FOXO3 signaling in modulation of PD-L1-HGF-decorated mesenchymal stem cells-derived exosomes on neuroplasticity in murine stroke. Advanced Science 2024, 2404882

2. Cheng HW, Lee W, Hsu FT, Lai YH, Huang SR, Lim CSH, Lin ZK, Hsu SC, Chiang CS, Jeng SB, Shyu WC* and Chen SY. Manipulating the crosstalk between cancer and immunosuppressive cells with phototherapeutic gold nanohut for reprogramming tumor microenvironment.Advanced Science 2024, 2404347

3. Lin SL, Lee W, Liu SP, Chang YW, Jeng LB and Shyu WC*. Novel programmed death ligand 1-AKT-engineered mesenchymal stem cells promote neuroplasticity to target stroke therapy. Molecular Neurobiology 2023;doi.org/10.1007/s12035-023-03779-w

4. Lai YH, Su CY, Cheng HW, Chu CY, Jeng LB, Chiang CS, Shyu WC* and Chen SY. Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture therapy in GBM. Nature Communication 2023;14:285.

5. Cheng HW, Chiang CS, Ho HY, Chou SH, Lai YH, Shyu WC*, Chen SY. Dextran-modified Quercetin-Cu(II)/hyaluronic acid nanomedicine with natural poly(ADP-ribose) polymerase inhibitor and dual targeting for programmed synthetic lethal therapy in triple-negative breast cancer.Journal of Controlled Release 2021:329:136-147.

6. Chiu HY, Lee HT, Lee KH, Zhao Y, Hsu CY, Shyu WC*. Mechanisms of ischemic neural progenitor proliferation: a regulatory role of the HIF-1α-CBX7 pathway. Neuropathology and Applied Neurobiology 2020;46, 391–405.

7. Lee YH, Lee HT, Chen CL, ChangCH, Hsu CY, Shyu WC*. Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP^C signaling. Theranostics 2019;9:6443-6465.

8. Chiang CS, Lin YJ, Lee R, Lai YH, ChengHW, Hsieh CH, Shyu WC*, Chen SY. Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy. Nature Nanotechnology 2018;13:746-754.

9. Fan JR, Lee HT, Lee W, Lin CH, Hsu CY, Hsieh CH and Shyu WC*. Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model. Cell Death and disease 2018;9:502. Times Cited=1

10.Chiu HY, Lin CH, Hsu CY, Yu J, Hsieh CH and Shyu WC*. IGF1R⁺ Dental Pulp Stem Cells Enhanced Neuroplasticity in Hypoxia-Ischemia Model. Mol Neurobiol 2017; 54:8225–8241. Times Cited=3

11.Lee HT, Liu SP, Lin CH, Lee W, Hsu CY, Sytwu HK, Hsieh CH, Shyu WC*. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics 2017;7: 855-875, Times Cited=6

12.Chen PJ, Kang YD, Lin CH, Hsieh CH, Chen YY, Chiang CW, Lee W, Hsu CY, Liao LD, Fan CT,  Li ML, Chen SY and Shyu WC*. Multitheragnostic Multi-GNRs Crystal-seeded Magnetic Nanoseaurchin for Enhanced In-vivo Mesenchymal Stem Cell Homing, Multimodal Imaging and Stroke Therapy. Advanced Material 2015;27(41),6488-6495. Times Cited=22

13. Lin CH, Chiu L, Lee HT, Chiang CW, Liu SP, Hsu YH, Lin SZ, Hsu CY, Hsieh CH. Shyu WC*. PACAP38/PAC1 Signaling Induces Bone Marrow-Derived Cells Homing to Ischemic Brain. Stem Cell 2015; 33(4):1153–1172. Times Cited=6

14. Hsieh CH, Lin YJ, Wu CP, Lee HT, Shyu WC*, Chi-Chung Wang. Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiforme. Clinical Cancer Research. 2015 January ;21(2):460-470. Times Cited=15

15. Lee SD, Lai TW , Lin SZ, Lin CH, Hsu YH, Li CY, Wang HJ, Lee W, Su CY, Yu YL, Shyu WC*. Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains. EMBO Mol Med.2013 Aug;5(8):1227–1246. Times Cited=0

16. Lin CH, Cho CW, Lee W, Lee SD, Lin SZ, Wang HJ, Okano H, Su CY, Yu YL, Hsu CY and Shyu WC*. Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model. Neurobiol Dis. 2013;58:76-91. Times Cited=0

17. Zhang S, Taghibiglou C, Lai TW, Wu DC, Dong Z, Wang I, Hsieh CH, Lin SZ, Shyu WC* and Wang YT. Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries. J Neurosci. 2013,33:7997-8008. Times Cited=0

18. Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, Hung MC. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.EMBO Mol Med. 2013;5:531-547. Times Cited=0

19. Lai TW, Shyu WC*, Wang YT. Stroke intervention pathways: NMDA receptors and beyond. TRENDS MOL MED. 2011;17:266-275. Times Cited=0